Protein

MCA_05507_1

Length
565 amino acids

Gene name: BNA4

Description: Kynurenine 3-monooxygenase

Browser: contigD:1495933-1497631-

RNA-seq: read pairs 4418, FPKM 96.4, percentile rank 78.1% (100% = highest expression)

Protein function

Annotation:BNA4Kynurenine 3-monooxygenase
KEGG:K00486KMO kynurenine 3-monooxygenase [EC:1.14.13.9]
EGGNOG:0PFFHBNA4Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
SGD closest match:S000000194BNA4Kynurenine 3-monooxygenase
CGD closest match:CAL0000200704BNA4Kynurenine 3-monooxygenase

Protein alignments

%idAln lengthE-value
MIA_02659_170.47%4910.0MIA_02659_1
A0A0J9XJC8_GEOCN66.67%4560.0Kynurenine 3-monooxygenase OS=Geotrichum candidum GN=BNA4 PE=3 SV=1
A0A1E3PNF7_9ASCO52.18%4586e-170Kynurenine 3-monooxygenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=BNA4 PE=3 SV=1
A0A060T854_BLAAD52.34%4496e-154Kynurenine 3-monooxygenase OS=Blastobotrys adeninivorans GN=BNA4 PE=3 SV=1
A0A161HI12_9ASCO47.97%4671e-149Kynurenine 3-monooxygenase OS=Sugiyamaella lignohabitans GN=BNA4 PE=3 SV=1
UniRef50_A0A161HI1247.97%4674e-146Kynurenine 3-monooxygenase n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HI12_9ASCO
KMO_CANAL49.10%4467e-147Kynurenine 3-monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BNA4 PE=3 SV=1
KMO_YARLI48.44%4502e-143Kynurenine 3-monooxygenase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BNA4 PE=3 SV=1
KMO_YEAST45.88%4493e-130Kynurenine 3-monooxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BNA4 PE=1 SV=1
A0A1E4TFI4_9ASCO48.67%3001e-90Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31448 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0013

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 565

Detailed signature matches

  1. Family IPR027545
    Kynurenine 3-monooxygenase
    1. MF_01971 (Kynurenin...)
  2. Domain IPR023753
    FAD/NAD(P)-binding domain
    1. G3DSA:3.50.50.60
    2. SSF51905 (FAD/NAD(P...)
  3. Domain IPR002938
    FAD-binding domain
    1. PF01494 (FAD_binding_3)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. PR00420 (RNGMNOXGNASE)
  4. TMhelix
  5. TRANSMEMBRANE (Tran...)
  6. mobidb-lite (disord...)

Protein sequence

>MCA_05507_1
MPLDVSINDDTVLVGSTESATKPNISSTTTSDNEDDYPKPIPHHPFLSSKISNIPSISRPAAAASYIITPDLNPDSSSAP
KKEVEPPREIKTVIIIGAGLVGCVAALAFKKRGYNVKVYEGRPDARTPEQRQIFSYRSINMAVSSRGITTLESIDPEMSK
RVLKNLIPMYGRMVHDMVGNEISQAYGLNGEAINSIDRADLNRGLLDELDAAGIETYFNYKLIYASLEPTPKLTFSLLPK
DGKKVAGEAFKNIVVVDDGDLIIGCDGAHSALRQHLSKYVRLNFEQEYIDSAYVELRIEPESHEEYDAHAKDDDRKFKLD
KNHLHIWPRHNHMLIALPNQDGSFTSTLFGPWSLFDSLDTEDKWFDFFWNDFPDVFEKGLMTRKMLVKAFHENPRGSLVC
VRCSPYHYKDRCIILGDAAHSMVPFYGQGMNCGFEDVKVLMSLLDKHNGNCRDAFDEYSATRHKDLTAIIDLAMRNYVEM
RHKVVSTSFLLRKKLDGVLSRILGNHWLPLYTMVTFRPDISYSEAMRRENLQAKIINDIVYYGTGLAAITGVVTFVKLVH
KLARN

GO term prediction

Biological Process

GO:0006569 tryptophan catabolic process
GO:0019805 quinolinate biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004502 kynurenine 3-monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding

Cellular Component

None predicted.