Protein

MIA_02619_1

Length
834 amino acids

Browser: contig03:1276241-1278799+

Protein function

EGGNOG:0PG0HFG00433.1serine threonine protein kinase
SGD closest match:S000006074RAD53Serine/threonine-protein kinase RAD53
CGD closest match:CAL0000193688RAD53Serine/threonine-protein kinase RAD53

Protein alignments

%idAln lengthE-value
MCA_01787_147.350%8680.0MCA_01787_1
A0A0J9XDG8_GEOCN42.672%7714.76e-179Serine/threonine-protein kinase RAD53 OS=Geotrichum candidum GN=BN980_GECA10s03024g PE=3 SV=1
UniRef50_A0A0J9XDG842.672%7719.75e-176Serine/threonine-protein kinase RAD53 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDG8_GEOCN
A0A060T6T4_BLAAD50.498%4022.47e-137Serine/threonine-protein kinase RAD53 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21846g PE=3 SV=1
A0A1D8PJZ1_CANAL45.122%4103.14e-116Serine/threonine-protein kinase RAD53 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD53 PE=3 SV=1
RAD53_YEAST45.387%4012.63e-113Serine/threonine-protein kinase RAD53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD53 PE=1 SV=1
Q6C079_YARLI44.828%3771.45e-99Serine/threonine-protein kinase RAD53 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F27093g PE=3 SV=1
A0A1E3PD17_9ASCO36.724%5804.34e-97Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48188 PE=4 SV=1
A0A1E4THZ6_9ASCO42.727%3304.55e-87Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14634 PE=3 SV=1
A0A167DWF9_9ASCO37.544%2852.83e-50Calmodulin-dependent protein kinase CMK1 OS=Sugiyamaella lignohabitans GN=CMK1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0273

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 834

Detailed signature matches

  1. Family IPR016256
    Serine/threonine-protein kinase Rad53
    1. PIRSF000661 (STPK_R...)
  2. Domain IPR008984
    SMAD/FHA domain
    1. SSF49879 (SMAD/FHA ...)
  3. Domain IPR000253
    Forkhead-associated (FHA) domain
    1. PF00498 (FHA)
    2. SM00240 (FHA_2)
    3. PS50006 (FHA_DOMAIN)
  4. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  5. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  6. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  7. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:2.60.20...
  3. G3DSA:3.30.20...
  4. cd00060 (FHA)
  5. mobidb-lite (disord...)

Residue annotation

  1. phosphopeptide bin...
  2. phosphopeptide bin...

Protein sequence

>MIA_02619_1
MEKEDSTQPNTREPANPDSIDAEPDDVCYLSCLTHHYGRIKLQSNNGTRFQWTFGRLPECNIQIDYSRRISKIHFIITKK
NENVLLKDVSTNGTLLNSIRIAKNKEYILAHGDEITIGSGVPGEEVKFFVTFPGTTSGTPTEGVHAQYDLRSEVLGQGAF
AVVKKAIERTTGNPYAVKIIDKKKIMSGVSVEREIDILKKLKHEYIVGLNDFFEDGNNYYLIMDLVSGGDLMDFVTSNGA
IPEEPSREIARQVLCALQYVHSLGISHRDIKPDNILIAQDEPVIVRISDFGLAKLTKSGSSLQTFCGTLAYLAPEIMAKK
HSENGKSTIYSNKVDIWSVGCMLYVILTGYLPFSNNTQNALYQSVLSGRFCMEPLISANISKPCLDFLHYVLDVNPDSRP
SAEQALQHYWFTKFSFDNDESQASEAEAAAAPSAATSGVNPAAPQPSLVPAPKSISIKRQPSVANHTKSAIKNPDDFPSM
RLVLESKTKEKNSDGDIDLPDVVSVPELEASSEDVPMVSPQTSKQTEQKETIKKAPVTSQPPTQKVGKVSEPKNAQNGHD
LNDSDEDGDEIRQAADAQFKNRVNQVNSIVKSLNNNNSSPLQSRPYISVVRDMDNQNAIDMPIGTWMILRTLDTSIPHED
ICITHPLLKFGRSSEIDNVFDLRDNRISKLHACIGVQPASPNSPSKNGLYKIFLGDWSRNGCYVNKEKIGKGQMAQLQDG
DVIYFFQETRAVEFLGFQVVIIDTPSFVSRPHADKNVILPFNEDPLRFKGWVKGTVSIGHLSSPISSSPINRNGYKHTRF
NESQSVTSPNTPGKRAHDESEGERPSKRVSRYKQ

GO term prediction

Biological Process

GO:0000077 DNA damage checkpoint
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0009202 deoxyribonucleoside triphosphate biosynthetic process

Molecular Function

GO:0003688 DNA replication origin binding
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005634 nucleus