MCA_01787_1
Gene name: RAD53
Description: DNA damage response protein kinase
Browser: contigA:5457808-5460762-
RNA-seq: read pairs 1148, FPKM 14.7, percentile rank 33.6% (100% = highest expression)
Protein function
| Annotation: | RAD53 | DNA damage response protein kinase | |
|---|---|---|---|
| EGGNOG: | 0PG0H | FG00433.1 | serine threonine protein kinase |
| SGD closest match: | S000006074 | RAD53 | Serine/threonine-protein kinase RAD53 |
| CGD closest match: | CAL0000193688 | RAD53 | Serine/threonine-protein kinase RAD53 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02619_1 | 47.30% | 869 | 0.0 | MIA_02619_1 |
| A0A0J9XDG8_GEOCN | 57.32% | 410 | 2e-147 | Serine/threonine-protein kinase RAD53 OS=Geotrichum candidum GN=BN980_GECA10s03024g PE=3 SV=1 |
| UniRef50_A0A0J9XDG8 | 57.32% | 410 | 5e-144 | Serine/threonine-protein kinase RAD53 n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDG8_GEOCN |
| A0A060T6T4_BLAAD | 48.56% | 418 | 1e-115 | Serine/threonine-protein kinase RAD53 OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B21846g PE=3 SV=1 |
| RAD53_YEAST | 42.21% | 462 | 2e-107 | Serine/threonine-protein kinase RAD53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD53 PE=1 SV=1 |
| A0A1D8PJZ1_CANAL | 44.82% | 386 | 6e-103 | Serine/threonine-protein kinase RAD53 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAD53 PE=3 SV=1 |
| Q6C079_YARLI | 43.86% | 399 | 3e-95 | Serine/threonine-protein kinase RAD53 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F27093g PE=3 SV=1 |
| A0A1E4THZ6_9ASCO | 41.21% | 330 | 3e-79 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14634 PE=3 SV=1 |
| A0A1E3PD17_9ASCO | 60.64% | 188 | 1e-70 | Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48188 PE=4 SV=1 |
| A0A167DWF9_9ASCO | 35.19% | 270 | 3e-44 | Calmodulin-dependent protein kinase CMK1 OS=Sugiyamaella lignohabitans GN=CMK1 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0089
Protein family membership
- Serine/threonine-protein kinase Rad53 (IPR016256)
Domains and repeats
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Domain
Detailed signature matches
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PIRSF000661 (STPK_R...)
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SSF49879 (SMAD/FHA ...)
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SSF56112 (Protein k...)
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PS00107 (PROTEIN_KI...)
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-
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PS00108 (PROTEIN_KI...)
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no IPR
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cd00060 (FHA)
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mobidb-lite (disord...)
Residue annotation
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phosphopeptide bin...
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phosphopeptide bin...
Protein sequence
>MCA_01787_1 MNNTQEKTQPDSKDPPEVGINPLEVGRLTCTTVPLDAIVLLKEKEVDEYTCGRHENNKIVIDFSKRISKYHFVIIRKGDT LVLKDISTNGTLLNGCRVEKNQQYILAQGDEITIGSGVKGEEVTFLLTLPGKFKPATSGIHAHYDLRSQVIGRGAFAHVK KAIERASGDEYAVKIIDKKKVMTGVAVEREIDILKKLKHEYIVGLRDFYEDANNYYLVMDLITGGDLMEFVTENGAIPEE PAREIARQVLLAVKYVHSLGISHRDIKPDNILIAQDEPVIVKVSDFGLAKISRSGSQLQTFCGTMAYLAPEIMARKQDNT ISAVYSNKVDIWSIGCMLYVILTTYLPFINTTQAILCHNVTTGNFVMEPLLKYGVSKTGINFLRSLLTVDPRKRPSSEEA LNHPWFNELTFNERGEPIEPKATPATNGRFPPVPKPVNTQKVQPTASKMLSLKRSSDSVIKSMNQLGIKNPEDFKKYEEE ELRYKQKNNTPELSVPSNVANGNDENGESNNKKAGNDNKDAEGDVDIPDADEVPDLDHSMESPLDVMMESPVPNKIRKTP IEEAIKPTPPATTSKVPPTQPIPNENKDTSPNKKVIFSSSAAAANRKKPPAIPEEKEDNECDSDKDSEEIKNIVREEALQ RANRVNSSVMESYLKSNTNSSSSPLQFKPFNSVVRDMDPNFEQDMYPPGTWMTLRALETSIPHNGISISLPMFRIGRANT PDHPVEWVEDDDFRLSAIHCVIALEPCNAAGEPLGPKDEVGPDTMYKVWLGDWSRNGCYINKRPIGKGNKALLQNHDHIF FFKDFENKQCLGFEVTFLEPLHFWKPPSSDKNKNNKNNNNNRTPIIVPFPETYNEFKGWTKMPQALLSPLPNRMGINNEG KLTTTANGGGKKKITNNNNNNNNIKEPETPTSKRTFSRLKNEEELLNSSKNKTTTNTNGNNNHNNNIQQEQQEPPTKKVS IRK
GO term prediction
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0009202 deoxyribonucleoside triphosphate biosynthetic process
Molecular Function
GO:0003688 DNA replication origin binding
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Cellular Component
GO:0005634 nucleus