Protein

MIA_02580_1

Length
1,848 amino acids


Browser: contig03:1179874-1185478+

Protein function

EGGNOG:0PFY5FAS2fatty acid synthase
SGD closest match:S000006152FAS2Fatty acid synthase subunit alpha
CGD closest match:CAL0000182497FAS2Trifunctional fatty acid synthase subunit

Protein alignments

%idAln lengthE-value
MCA_05244_186.105%18640.0MCA_05244_1
A0A0J9XEN9_GEOCN80.829%18570.0Similar to Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase OS=Geotrichum candidum GN=BN980_GECA11s00153g PE=3 SV=1
A0A060T3L0_BLAAD75.148%18590.0ARAD1A16676p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16676g PE=3 SV=1
A0A1E3PQN4_9ASCO72.830%18550.0Alpha subunit of fatty acid synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=FAS2 PE=3 SV=1
A0A161HHZ5_9ASCO75.194%18020.0Trifunctional fatty acid synthase subunit FAS2 OS=Sugiyamaella lignohabitans GN=FAS2 PE=3 SV=1
A0A1D8PK65_CANAL66.490%18920.0Trifunctional fatty acid synthase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FAS2 PE=3 SV=1
UniRef50_P4309866.244%18930.0Fatty acid synthase subunit alpha n=21 Tax=saccharomyceta TaxID=716545 RepID=FAS2_CANAX
Q6CE16_YARLI66.702%18620.0YALI0B19382p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B19382g PE=4 SV=1
FAS2_YEAST62.771%18910.0Fatty acid synthase subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAS2 PE=1 SV=2
A0A1E4TI24_9ASCO61.946%18500.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32052 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0907

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1600 1848

Detailed signature matches

    1. MF_00101 (AcpS)
    1. PIRSF000454 (FAS_ye...)
    1. SSF52151 (FabD/lyso...)
    1. SSF51735 (NAD(P)-bi...)
    1. SSF53901 (Thiolase-...)
    1. PF00109 (ketoacyl-synt)
    1. PF02801 (Ketoacyl-s...)
    1. PF01648 (ACPS)
    2. SSF56214 (4'-phosph...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00828 (elong_cond...)
  2. cd08950 (KR_fFAS_SD...)
  3. mobidb-lite (disord...)

Residue annotation

  1. putative NAD(P) bi...
  2. active site cd08950
  3. active site cd00828

Protein sequence

>MIA_02580_1
MKPEVEQELAHILLTELLAYQFASPVRWIETQDVILKDYNAERVVEIGPSPTLAGMATRTLKAKYESYDAALSLQRQVLC
YSKDTKEIYYTPDPPAEPEAPAAAPAAVAAPAAAPAAAAAPVAAAPAAGPAAAVDDTPVKAIEILHALVAQKLKKTLDQV
PLSKSIKDLVGGKSTVQNEILGDLGKEFGGAPDKPEEVPLGELAEAFQQSFSGQLGKQSSSLISKLMSSKMPGGFSITSA
RKYLSDRYGLGQGRQDSVFLVAITQEPKNRLGAEPEAKAFLDECANKYAASAGISLSAGAGAGAGGAGAAAGGAVIDSAA
FEELTKDQKYLVRQQLELFANYLKVDIRKGDKALLAQKEATALLQTELDLWNQEHGEFYAQGIKPVFSPLKARTYDSYWN
WARQDALKMFWDVIFGKLDTVDREIVANCISLMNRANPTFIDFVQYHMDHVPTERGATYKLVKELGIQLLENCKESLNAD
PVYKDVNYPTGPQTTVDEKGNMSYKEVPRPSVRKLEHYVQEMAQGGPITKDPKANAQAELARIYQTLSSQNSNSASKTKL
DSLYAELNKVIEAINADTSSAKTSEKIDRVSASVPKDTVPFLHLKSRSGDEWSYDRTLSGAYLDGLETAAKEGITFANKN
VLITGAGAGSIGADILQGLLSGGAKVVVTTSRYSRQVTEFYQSIYTRYGAAGSTLIVVPFNQASKTDVLGLVDFIYNDPK
KGGLGWDLDFVIPFAAIPENGIEIDGIDSKSELAHRLMLTNVLRLVGAVKTHKANNGVITRPAQVILPLSPNHGTFGADG
LYSESKLSLETLFNRWHSESWGPYLTICGAVIGWTRGTGLMSQNNAIAEGVEKMGVRTFSQKEMAFNILGLLTPQIVKLA
QQSPVFADLNGGLQFIENLKDLTGRLRSELAEKTDIRRAVSIETAIEHRVTNGETADAPYRRVVVQPRANETYAFPTLKS
FDELKKVAPELEGMLDLERVVVVTGFAEVGPWGNARTRWQMEANGTFSLEGAIEMAWIMGLIKHHNGPLKGKPYSGWVDA
KTNEPVDDKDIKAKYEAYVLDHSGIRLIEPELFNGYDPLKKQFLQEVIIEHDLEPFESSKEAADQFKLEQGDKVETFEIE
GTDQFTVRFLKGARILVPKALKFNRLVAGQIPTGWDARRYGISEDTISQVDPVTLYALVSTVEALMASGITDPFEFYKYV
HLSEVGNCSGSGMGGVSALRGMFKDRYLDIPVQNDILQESFINTMSAWVNMLLISSSGPIKTPVGACATSIESADVGIET
ILSGKAKIVFIGGYDDFQEEGSYEFGNMKATSDSTTEEAHGRTPAEMSRPTSTSRSGFMEAQGAGIQVAMSAKLAIEMGV
PIYGIVALTATATDKIGRSVPAPGRGILTTARENQDNKFPHRLLDIKYRRKQLEKRRTQVKEWLNDEYEYLADEVEALKK
GDDKFDAATYYKERAEQIDFEAARQEKEARNHWGNEFWKQDPRIAPLRGALATFNLTIDDIGIASFHGTSTKANDKNESA
TINDMLNHLGRSKGNPVLGVFQKYLTGHPKGAAGAWMLNGVLQILNSGIVPGNRNADNVDPVMEKFDKILYPSITMQTDG
IKAASVTSFGFGQKGAQLIAIHADYVLAALSKSQYEEYAKKVAARYKKAYRYMHNAIAEQTMFVAKNKPPYTDDQESSVY
LNPLARVDYDKKTESLIFNQKKIVQAKYGSSSGHTEEVVKALAQSNTSSNVGVDVELLSAVNIENETFLERNFTEAERKY
CAAQADPQASFTGTWSAKEAVFKALNTAGKGAGAALDEIEILRSPKGAPYVVLHKDAEAAAKKEGVKSVKISISHNEFQA
VAVAIAEK

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0042759 long-chain fatty acid biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004312 fatty acid synthase activity
GO:0008897 holo-[acyl-carrier-protein] synthase activity

Cellular Component

None predicted.