Protein

MCA_05244_1

Length
1,865 amino acids

Gene name: FAS2

Description: Fatty acid synthase subunit alpha

Browser: contigD:737349-743018-

RNA-seq: read pairs 65225, FPKM 431.9, percentile rank 93.8% (100% = highest expression)

Protein function

Annotation:FAS2Fatty acid synthase subunit alpha
KEGG:K00667FAS2 fatty acid synthase subunit alpha, fungi type [EC:2.3.1.86]
EGGNOG:0PFY5FAS2fatty acid synthase
SGD closest match:S000006152FAS2Fatty acid synthase subunit alpha
CGD closest match:CAL0000182497FAS2Trifunctional fatty acid synthase subunit

Protein alignments

%idAln lengthE-value
MIA_02580_185.84%18640.0MIA_02580_1
A0A0J9XEN9_GEOCN80.94%18630.0Similar to Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase OS=Geotrichum candidum GN=BN980_GECA11s00153g PE=3 SV=1
A0A060T3L0_BLAAD74.30%18640.0ARAD1A16676p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16676g PE=3 SV=1
A0A1E3PQN4_9ASCO71.53%18650.0Alpha subunit of fatty acid synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=FAS2 PE=3 SV=1
A0A161HHZ5_9ASCO74.20%18100.0Trifunctional fatty acid synthase subunit FAS2 OS=Sugiyamaella lignohabitans GN=FAS2 PE=3 SV=1
A0A1D8PK65_CANAL67.11%19000.0Trifunctional fatty acid synthase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FAS2 PE=3 SV=1
UniRef50_P4309866.70%19010.0Fatty acid synthase subunit alpha n=21 Tax=saccharomyceta TaxID=716545 RepID=FAS2_CANAX
Q6CE16_YARLI66.31%18700.0YALI0B19382p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B19382g PE=4 SV=1
FAS2_YEAST64.89%18940.0Fatty acid synthase subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAS2 PE=1 SV=2
A0A1E4TI24_9ASCO61.46%18580.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32052 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0474

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1600 1865

Detailed signature matches

  1. Family IPR002582
    Holo-[acyl carrier protein] synthase
    1. MF_00101 (AcpS)
  2. Family IPR026025
    Fatty acid synthase alpha subunit, yeast
    1. PIRSF000454 (FAS_ye...)
  3. Domain IPR016035
    Acyl transferase/acyl hydrolase/lysophospholipase
    1. SSF52151 (FabD/lyso...)
  4. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  5. Domain IPR016039
    Thiolase-like
    1. SSF53901 (Thiolase-...)
    2. G3DSA:3.40.47.10
  6. Domain IPR014030
    Beta-ketoacyl synthase, N-terminal
    1. PF00109 (ketoacyl-synt)
  7. Domain IPR014031
    Beta-ketoacyl synthase, C-terminal
    1. PF02801 (Ketoacyl-s...)
  8. Domain IPR008278
    4'-phosphopantetheinyl transferase superfamily
    1. PF01648 (ACPS)
    2. SSF56214 (4'-phosph...)
    3. G3DSA:3.90.47...
  9. Domain IPR004568
    Phosphopantetheine-protein transferase domain
    1. TIGR00556
    2. PD004282
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.36...
  3. G3DSA:3.40.50...
  4. cd00828 (elong_cond...)
  5. cd08950 (KR_fFAS_SD...)
  6. mobidb-lite (disord...)

Residue annotation

  1. putative NAD(P) bi...
  2. active site cd08950
  3. active site cd00828

Protein sequence

>MCA_05244_1
MPMKPEVEQELAHILLTELLAYQFASPVRWIETQDVILKDYNAERIVEIGPSSTLAGMATRTLKAKYESYDAALSLQREV
LCYAKDTKEIYYTPDPVEPPAAAEPAASETPAPAPAPAAAAAAPVAAAPVAAAPAAGPAASIEDAPVKAIEVLHALVAQK
LKKPTDQVPLTKSIKDLVGGKSTVQNEILGDLGKEFGAAPDKPEDVPLGELAEAFQQSFNGQLGKQSSSLVSKLMSSKMP
GGFSITSARKYLTDRFGLGNGRQDSVFLVAITLEPKNRLGSEAEAKAFLDECAQKYASAAGINLSSAAAAGGAGAGGAGG
GAVMDTAAFEELTKDQKHLYRQQLELLARYLKMDLRKGDKALLAQKEAADVLQAEIDLWNQEHGDFYAAGIKPVFSPLKA
RTYDSYWNWARQDALNMFWDVIFGRLDTVDREIVSRCISLMNRSNPAFIDFVQYHIDHVPTERGPTYKLVKELGVQLLEN
CKESLNADPVYKDVTYPTGPQTTVDEKGNMTYKEVPRPSVRKLEHYVQEMAQGGPITKDNKAGVHAQAELAKIYETLTSQ
HNDTKLPADVKSKLDTLYAEFNKVLDTVTKDLSGSTSEKLDRVSSTIPKGTVPFLHLKSRVGDEWSYDRDLSGTYLDALE
QAAKEGVTFANKNVLITGAGAGSIGADILQGLLSGGAKVVVTTSRYSRQVTEFYQSIYTRYGAAGSSLTVVPFNQASKTD
VLALVDYIYNDPKKGGLGWDLDFIIPFAAIPENGIEIDGIDSKSELAHRLMLTNVLRLVGAVKTHKANNGIITRPAQVIL
PLSPNHGTFGADGLYSESKLSLETLFNRWHSESWAPYLTICGAVIGWTRGTGLMSQNNAIAEGVEKMGVRTFSQKEMAFN
ILGLLNPKIVNLCQQSPVFADLNGGLQFIPNLKELTGRLRSELAEKTDIRRAVSIETALEHKVVNGPAADAPFQKVIVQP
RANQAFAFPTLKPYKEIKKIAPELEGMLDLERVVVITGFAEVGPWGNARTRWQMESTGTFSLEGAIEMAWIMGLIKYHNG
PLKGKPYSGWVDAKTSEPVDEKDIKAKYEEYILDHAGIRLIEPELFNGYDPNQKQFLQEVIIEHDLEPFEASKEAADQFK
LEQGDKVETFVIEGTDQYTVRFLKGARILVPKALKFNRLVAGQIPTGWDARRYGIPEDTISQVDPVTLYALVSTVEALMA
SGITDPFEFYKYVHLSEVGNCSGSGMGGVSALRGMFKDRYMDLPVQNDILQESFINTMSAWVNMLLISSSGPIKTPVGAC
ATSIESADIGIETILSGKAKIVFIGGYDDFQEEGSYEFANMKATSDSIEEEAHGRTPAEMSRPSATSRNGFMEAQGAGIQ
VAMNAKLAIEMGVPIYGIVALTATASDKIGRSVPAPGRGILTTARENQDNKFPHRLLDIKYRKKQLEKRREQIKQWLNDE
YEYLQDEIDTLKSTEGESFDAATYYKERAEQLEYEATRQEKEARNHWGNEFWKQDPRIAPLRGALATYNLTIDDIGVASF
HGTSTKANDKNESATINDMLNHLGRSKGNPVFGVFQKYLTGHPKGAAGAWMLNGVLQILNTGIVPGNRNADNVDTVMEKF
DKILYPSVTMQTDGIKAASVTSFGFGQKGAQAIAIHPDYVLATLSESEYKTYAEKVAARYKKAYRYMHNAICENSMFVAK
DKPPYTDDQESQVYLNPLARVDFNKKTETLTFNQKEIVQAPYSTSTGHTEDIVKSLTESAKASSSGNVGVDVELLASVPI
ENETFVERNFTKAEIEYCSASSNPRASFTGTWSAKEAVFKALNSAGKGAGAPLKEIEILRSSKGAPYVVLHGDAEKAASK
EGIKSVKISISHNDSQAVAVAIADK

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0042759 long-chain fatty acid biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004312 fatty acid synthase activity
GO:0008897 holo-[acyl-carrier-protein] synthase activity

Cellular Component

None predicted.