MIA_02530_1

Protein

Length

222 amino acids

Protein function

EGGNOG:	0PG7P	HIS3	Imidazoleglycerol-phosphate dehydratase
SGD closest match:	S000005728	HIS3	Imidazoleglycerol-phosphate dehydratase
CGD closest match:	CAL0000187142	HIS3	Imidazoleglycerol-phosphate dehydratase

Protein alignments

	%id	Aln length	E-value
MCA_02993_1	79.646%	226	7.57e-124	MCA_02993_1
A0A060T5I4_BLAAD	77.523%	218	6.78e-118	Imidazoleglycerol-phosphate dehydratase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B04708g PE=3 SV=1
A0A167E2V0_9ASCO	77.064%	218	4.30e-114	Imidazoleglycerol-phosphate dehydratase HIS3 OS=Sugiyamaella lignohabitans GN=HIS3 PE=3 SV=1
A0A1E3PGA9_9ASCO	73.636%	220	1.05e-113	Imidazoleglycerol-phosphate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52895 PE=3 SV=1
A0A0J9XJ19_GEOCN	76.606%	218	1.08e-111	Imidazoleglycerol-phosphate dehydratase OS=Geotrichum candidum GN=BN980_GECA23s01044g PE=3 SV=1
Q59LL5_CANAL	74.208%	221	9.38e-110	Imidazoleglycerol-phosphate dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS3 PE=3 SV=1
UniRef50_J8TYG0	72.973%	222	7.37e-104	Imidazoleglycerol-phosphate dehydratase n=2 Tax=Saccharomyces TaxID=4930 RepID=J8TYG0_SACK1
HIS7_YEAST	69.820%	222	6.45e-109	Imidazoleglycerol-phosphate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS3 PE=1 SV=2
A0A1E4TJQ6_9ASCO	67.890%	218	1.18e-98	Imidazoleglycerol-phosphate dehydratase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_566 PE=3 SV=1
Q6C3L0_YARLI	64.384%	219	8.37e-97	Imidazoleglycerol-phosphate dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33957g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3874

Protein family membership

Imidazoleglycerol-phosphate dehydratase (IPR000807)

Domains and repeats

Domain
4 - 113
Ribosomal protein S5 domain 2-type fold (IPR020568)
116 - 208
Ribosomal protein S5 domain 2-type fold (IPR020568)

1 50 100 150 222

Detailed signature matches

IPR000807

Imidazoleglycerol-phosphate dehydratase
1. cd07914 (IGPD)
  
  8 - 222
  
  CDD
  cd07914 (IGPD)
2. PF00475 (IGPD)
  
  61 - 203
  
  Pfam
  PF00475 (IGPD)
3. MF_00076 (HisB)
  
  5 - 222
  
  HAMAP
  MF_00076 (HisB)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  116 - 208
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
  
  4 - 113
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR020565

Imidazoleglycerol-phosphate dehydratase, conserved site
1. PS00954 (IGP_DEHYDR...)
  
  90 - 103
  
  PROSITE patterns
  PS00954 (IGP_DEHYDRATASE_1)
2. PS00955 (IGP_DEHYDR...)
  
  185 - 197
  
  PROSITE patterns
  PS00955 (IGP_DEHYDRATASE_2)

no IPR

Unintegrated signatures

G3DSA:3.30.23...

5 - 117

GENE3D
G3DSA:3.30.230.40 (G3DSA:3.30.230.40)

119 - 222

GENE3D
G3DSA:3.30.230.40 (G3DSA:3.30.230.40)

Residue annotation

putative active si...

15E

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

67H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

71A

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

74K

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

75H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

93H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

94H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

97E

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

119R

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

127L

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

128D

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

141R

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

165H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

189H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

190H

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

193E

putative active site pocket
15E, 67H, 71A, 74K, 75H, 93H, 94H, 97E, 119R, 127L, 128D, 141R, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)
4-fold oligomeriza...

63G

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

64F

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

67H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

89H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

90I

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

91D

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

93H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

94H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

152R

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

153E

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

154K

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

155I

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

156G

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

159S

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

161E

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

164P

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

165H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

186K

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

187N

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

188D

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

189H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)

190H

4-fold oligomerization interface
63G, 64F, 67H, 89H, 90I, 91D, 93H, 94H, 152R, 153E, 154K, 155I, 156G, 159S, 161E, 164P, 165H, 186K, 187N, 188D, 189H, 190H
CDD
cd07914 (IGPD)
metal binding resi...

67H

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

93H

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

94H

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

97E

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

165H

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

189H

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

190H

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)

193E

metal binding residues
67H, 93H, 94H, 97E, 165H, 189H, 190H, 193E
CDD
cd07914 (IGPD)
3-fold/trimer inte...

118K

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

120F

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

122H

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

123G

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

124F

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

126P

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

127L

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

128D

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

130A

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

131L

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

135V

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

136V

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

137D

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

141R

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

143Y

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

177T

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

179H

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

181D

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

183I

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

201I

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

204R

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

210T

3-fold/trimer interface
118K, 120F, 122H, 123G, 124F, 126P, 127L, 128D, 130A, 131L, 135V, 136V, 137D, 141R, 143Y, 177T, 179H, 181D, 183I, 201I, 204R, 210T
CDD
cd07914 (IGPD)

Protein sequence

>MIA_02530_1
MSERRATTLIRNTNETKIQIALSLDGGPVALEKSLFKKDGEEEAGHAAQNSSSQVISVNSGVGFLDHMLHALAKHSGWSL
ILECIGDIHIDDHHTAEDCAIALGSAFKQALGQIKGVKRFGHGFAPLDEALSRAVVDLSNRPYCVTELQLVREKIGDLST
EMIPHVFESFATAASITLHVDVIRGKNDHHKAESAFKALAIAIREAISRTGTNEVPSTKGVL

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0004424 imidazoleglycerol-phosphate dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features