MCA_02993_1

Protein

Length

226 amino acids

Gene name: HIS3

Description: Imidazoleglycerol-phosphate dehydratase

Browser: contigB:3026190-3026871+

RNA-seq: read pairs 776, FPKM 42.2, percentile rank 61.6% (100% = highest expression)

Protein function

Annotation:		HIS3	Imidazoleglycerol-phosphate dehydratase
KEGG:	K01693	hisB	imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]
EGGNOG:	0PG7P	HIS3	Imidazoleglycerol-phosphate dehydratase
SGD closest match:	S000005728	HIS3	Imidazoleglycerol-phosphate dehydratase
CGD closest match:	CAL0000187142	HIS3	Imidazoleglycerol-phosphate dehydratase

Protein alignments

	%id	Aln length	E-value
MIA_02530_1	79.65%	226	1e-123	MIA_02530_1
A0A167E2V0_9ASCO	74.32%	222	4e-112	Imidazoleglycerol-phosphate dehydratase HIS3 OS=Sugiyamaella lignohabitans GN=HIS3 PE=3 SV=1
A0A060T5I4_BLAAD	72.57%	226	5e-111	Imidazoleglycerol-phosphate dehydratase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B04708g PE=3 SV=1
Q59LL5_CANAL	74.44%	223	1e-110	Imidazoleglycerol-phosphate dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS3 PE=3 SV=1
A0A1E3PGA9_9ASCO	72.07%	222	3e-108	Imidazoleglycerol-phosphate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52895 PE=3 SV=1
HIS7_YEAST	69.03%	226	6e-105	Imidazoleglycerol-phosphate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS3 PE=1 SV=2
A0A0J9XJ19_GEOCN	69.37%	222	5e-103	Imidazoleglycerol-phosphate dehydratase OS=Geotrichum candidum GN=BN980_GECA23s01044g PE=3 SV=1
UniRef50_J8TYG0	66.52%	227	1e-97	Imidazoleglycerol-phosphate dehydratase n=2 Tax=Saccharomyces TaxID=4930 RepID=J8TYG0_SACK1
A0A1E4TJQ6_9ASCO	64.41%	222	1e-94	Imidazoleglycerol-phosphate dehydratase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_566 PE=3 SV=1
Q6C3L0_YARLI	56.95%	223	3e-85	Imidazoleglycerol-phosphate dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E33957g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2556

Protein family membership

Imidazoleglycerol-phosphate dehydratase (IPR000807)

Domains and repeats

Domain
4 - 117
Ribosomal protein S5 domain 2-type fold (IPR020568)
121 - 211
Ribosomal protein S5 domain 2-type fold (IPR020568)

1 50 100 150 200 226

Detailed signature matches

IPR000807

Imidazoleglycerol-phosphate dehydratase
1. cd07914 (IGPD)
  
  8 - 226
  
  CDD
  cd07914 (IGPD)
2. PF00475 (IGPD)
  
  65 - 207
  
  Pfam
  PF00475 (IGPD)
3. MF_00076 (HisB)
  
  5 - 226
  
  HAMAP
  MF_00076 (HisB)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  4 - 117
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
  
  121 - 211
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR020565

Imidazoleglycerol-phosphate dehydratase, conserved site
1. PS00954 (IGP_DEHYDR...)
  
  94 - 107
  
  PROSITE patterns
  PS00954 (IGP_DEHYDRATASE_1)
2. PS00955 (IGP_DEHYDR...)
  
  189 - 201
  
  PROSITE patterns
  PS00955 (IGP_DEHYDRATASE_2)

no IPR

Unintegrated signatures

G3DSA:3.30.23...

123 - 226

GENE3D
G3DSA:3.30.230.40 (G3DSA:3.30.230.40)

5 - 121

GENE3D
G3DSA:3.30.230.40 (G3DSA:3.30.230.40)

Residue annotation

putative active si...

15E

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

71H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

75A

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

78K

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

79H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

97H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

98H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

101E

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

123R

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

131L

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

132D

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

145R

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

169H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

193H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

194H

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

197E

putative active site pocket
15E, 71H, 75A, 78K, 79H, 97H, 98H, 101E, 123R, 131L, 132D, 145R, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)
4-fold oligomeriza...

67G

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

68F

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

71H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

93H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

94I

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

95D

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

97H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

98H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

156R

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

157E

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

158K

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

159V

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

160G

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

163S

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

165E

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

168P

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

169H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

190R

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

191N

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

192D

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

193H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)

194H

4-fold oligomerization interface
67G, 68F, 71H, 93H, 94I, 95D, 97H, 98H, 156R, 157E, 158K, 159V, 160G, 163S, 165E, 168P, 169H, 190R, 191N, 192D, 193H, 194H
CDD
cd07914 (IGPD)
metal binding resi...

71H

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

97H

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

98H

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

101E

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

169H

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

193H

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

194H

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)

197E

metal binding residues
71H, 97H, 98H, 101E, 169H, 193H, 194H, 197E
CDD
cd07914 (IGPD)
3-fold/trimer inte...

122K

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

124F

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

126H

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

127G

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

128F

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

130P

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

131L

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

132D

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

134A

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

135L

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

139V

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

140I

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

141D

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

145R

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

147Y

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

181T

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

183H

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

185D

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

187L

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

205I

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

208K

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

214T

3-fold/trimer interface
122K, 124F, 126H, 127G, 128F, 130P, 131L, 132D, 134A, 135L, 139V, 140I, 141D, 145R, 147Y, 181T, 183H, 185D, 187L, 205I, 208K, 214T
CDD
cd07914 (IGPD)

Protein sequence

>MCA_02993_1
MPDRRATTISRITNETKIQIALSIDGGFISLEKSLFAKDNDSDSTQKDEHAAQNSSSQVINVNSGIGFLDHMFHALAKHS
GWSLILECIGDLHIDDHHTAEDCGIALGTAFKQAMGPIKGVKRFGHGFAPLDEALSRAVIDLSNRPYACVDLQLVREKVG
DLSTEMIPHVLESFATAAGVTLHVDVLKGRNDHHKAESAFKALAIAMKEATFRTGSNDVPSTKGVL

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0004424 imidazoleglycerol-phosphate dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features