Protein

MIA_02522_1

Length
998 amino acids

Browser: contig03:1037384-1040381+

Protein function

EGGNOG:0PGV4PGUG_01756ferric-chelate reductase activity
SGD closest match:S000004037FRE8Probable ferric reductase transmembrane component 8
CGD closest match:CAL0000198623orf19.4843Putative ferric-chelate reductase

Protein alignments

%idAln lengthE-value
MCA_01425_168.98%4030.0MCA_01425_1
A0A0J9YHI4_GEOCN52.78%3964e-122Similar to Saccharomyces cerevisiae YGL160W AIM14 NADPH oxidase localized to the perinuclear ER OS=Geotrichum candidum GN=BN980_GECA01s04927g PE=4 SV=1
UniRef50_A0A0J9XCH252.78%3962e-109Similar to Saccharomyces cerevisiae YLR047C FRE8 Protein with sequence similarity to iron/copper reductases n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCH2_GEOCN
A0A060TCP9_BLAAD45.50%3898e-86ARAD1D40370p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40370g PE=4 SV=1
Q6CEA2_YARLI38.62%3913e-61YALI0B17292p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B17292g PE=4 SV=1
A0A1E3PUF0_9ASCO31.23%3976e-51Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81492 PE=4 SV=1
A0A161HFK1_9ASCO33.99%4092e-46Aim14p OS=Sugiyamaella lignohabitans GN=AIM14 PE=4 SV=1
FRE8_YEAST33.09%4143e-46Probable ferric reductase transmembrane component 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE8 PE=1 SV=1
Q5APC2_CANAL30.37%4052e-42Putative ferric-chelate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4843 PE=4 SV=1
A0A1E4THS6_9ASCO31.88%4361e-32Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_122182 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0498

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 998

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:3.40.50.80
  3. NON_CYTOPLASM... (N...)
  4. SFLDF00463 (AIM14)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SSF52343 (Ferredoxi...)
  8. TMhelix
  9. TRANSMEMBRANE (Tran...)
  10. cd06186 (NOX_Duox_l...)
  11. mobidb-lite (disord...)

Residue annotation

  1. FAD binding motif ...
  2. FAD binding pocket...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MIA_02522_1
MSGWHFANDLTKPDKIQRAVTTSRYGVYSFIFIFSCLAVFSFVSLVFPRVHSIKSILAFQRLHDLDKKKNENHTIFKDDH
SHLSQDDLSNINHKPHHISGSKLGAPHQHYHHSHHDQNDLNYPNQLSHLSHNSEISGNASSLSPNGRNLIDIIEAPASSS
VTPNTPSSMIKSTSNSSTVKLYSNECNSSSSSVSSSTIQQDEDDDSINNESFDEFNYHPRTQEVQSIRQVPSHVSTSPRS
LSFNLPPPKPFISEKIDKYIFFYSKTLPSRTVKLPLVPIILFWSAVFIVLILRETQQEFTYLAKRLGRVPVALLPATYFL
TLRPSPLPQTFYLQLVPFHKWLARIVFLILVAHGIVYLYIYSNMGKLSKLLVLSNISGIVAFFLFVVIVITSLKPFRRRY
YNTIFFPIHYVSTWIVLPLIYYHSPGTTAPYVYICLGILIFQTGYRIYLSRENVQLPVQYISSSMLFVALPRDKLPKSLQ
HYYSPGSHLRVSSSPCIAYRISSLFSSQQSTSNPLLPTAHTGTKGPRPNGGLLSSLVQSTHPYTIASLPQDPVLLLCIRK
TRFPIRLRRAYTVTGPFFSISSPFLSDVNNGLVKRALFVAGGTGIAFCAPLMRHLRAMDIPVKLLWAIRDQNDAKVLVHL
GLVKAALEDHQIEIYVTRGYRAQNHNQAKKTHGFITYPDSATATATTMAASAQPAAAATTSATTATNLSAPPIAQSDNAV
LTTESSSLLAKHSKPSSNNNKSGKGKLRGYGSIETGAANSSSDDTDDEEHEQELRAASGFQGMFTPQTDDERFMVTIDNT
WCDGGERPYLLSRDSGPNEPGYVDEMGYISSSPGTQQNGTVAGVNGVSPAKGASLPSPSANVAQAPIPNTKRSAGMFSTF
KKTLLGEASSKKHQARSDSPFKIGLARHNPDLDLDFTPLMINSRPVLNLRLKSWLHGIAVDDNTCCCVDQLLQVDKATMM
GTSAGRWILASGGETLVGETERWASENGFSFFKDEFSL

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.