Protein

MCA_01425_1

Length
902 amino acids

Browser: contigA:4426598-4429307+

RNA-seq: read pairs 1476, FPKM 20.2, percentile rank 41.7% (100% = highest expression)

Protein function

EGGNOG:0PGV4PGUG_01756ferric-chelate reductase activity
SGD closest match:S000004037FRE8Probable ferric reductase transmembrane component 8
CGD closest match:CAL0000198623orf19.4843Putative ferric-chelate reductase

Protein alignments

%idAln lengthE-value
MIA_02522_169.23%4030.0MIA_02522_1
A0A0J9YHI4_GEOCN49.20%4372e-131Similar to Saccharomyces cerevisiae YGL160W AIM14 NADPH oxidase localized to the perinuclear ER OS=Geotrichum candidum GN=BN980_GECA01s04927g PE=4 SV=1
UniRef50_A0A0J9XCH251.93%3894e-116Similar to Saccharomyces cerevisiae YLR047C FRE8 Protein with sequence similarity to iron/copper reductases n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCH2_GEOCN
A0A060TCP9_BLAAD39.20%4493e-94ARAD1D40370p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40370g PE=4 SV=1
Q6CEA2_YARLI35.35%3965e-65YALI0B17292p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B17292g PE=4 SV=1
A0A1E3PUF0_9ASCO34.38%3841e-59Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81492 PE=4 SV=1
FRE8_YEAST33.76%3911e-53Probable ferric reductase transmembrane component 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE8 PE=1 SV=1
A0A161HFK1_9ASCO31.42%4525e-52Aim14p OS=Sugiyamaella lignohabitans GN=AIM14 PE=4 SV=1
Q5APC2_CANAL24.93%7186e-51Putative ferric-chelate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.4843 PE=4 SV=1
A0A1E4THS6_9ASCO29.38%3888e-31Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_122182 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5219

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 902

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDF00463 (AIM14)
  6. SFLDG01168 (Ferric_...)
  7. SFLDS00052 (Ferric_...)
  8. SSF52343 (Ferredoxi...)
  9. TMhelix
  10. TRANSMEMBRANE (Tran...)
  11. cd06186 (NOX_Duox_l...)
  12. mobidb-lite (disord...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MCA_01425_1
MTKWHIGKSFSPEEKALRSAITTKYGDYTLYFLTLSLLLFSFVCVFFPRFHSLHSVLKARKSLSRKKSATHHKPLIAYPD
STPSPTNCTVITEGQHLHRTPVEINPNTQTNSIKSSLDAKPQNYSPTSISSTSSTNSILPIAAPIPTIVNPSNSNSETTP
LLKKCNSSASLKLPLYYSCYDENETALSRPCNKFKLKSLVSPRLRSSLNSFKRRMQKLLSAASKYIYVYSPSLPSQQVKL
PLIPILLVWALAFTFLIFRETQYEFTYLAKRLGRVPVAMLPVTYFLTLRPSPLPQVFYLQLVPFHKWLSRIVFILIVGHA
AVYLYLYISMGKLFKLLHYSNLSGIVAFGLFILLIITSLKPIRRRYYNNLFFPTHFVTTWIVLPLIYYHSPKATAPYVYL
CLFVLLFQAVYRYYLSKSNLQLPVQSISSTMLYISLPKSQLPKSLQGYYPPGSHLRISSTPIFPTWFLPTWIRSRLKSAK
PNSGFLSSLVQSTHPYTISSLPQDPTVTLCIRKTRFPIRLRRNYTITGPYASIPSPFFEDLRNGKVKRALFIAGGTGIAF
CAPLMRHLRSMNVQVKLLWAIRDMNDAKVLVNLGLAQAALEDRQIEIYITKGSQHGPGSGLIGGMMDDDFENFNRLGMFQ
GMFAPQTDDERFMVTIDNTLCDGGEDRTIGPSKNKIPCIDGAGCVRSNSDGSDDYDNTQNKKQSENALSQVGYDDSYIER
ALSPALPSSYDSNQFLIPGFISPSETRPNSRNASQNNSRRGSYVNVAAANSSTSLHRSDSNGSSSNLTVSNYYTPHHNHS
TSLQSVLFTKARQNYKLDLDFTSIMINSRPVLNLRIKTWLYGVAVDGNTCCCVDQYANLDEEVKNDTSGRWILASGGETL
VKETEKWASANKFSFFKDEFSL

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.