Protein

MIA_02506_1

Length
524 amino acids

Browser: contig03:998723-1000298+

Protein function

EGGNOG:0PFQHFG04261.1ribose-phosphate pyrophosphokinase
SGD closest match:S000001664PRS1Ribose-phosphate pyrophosphokinase 1
CGD closest match:CAL0000189135orf19.969Ribose phosphate diphosphokinase subunit

Protein alignments

%idAln lengthE-value
A0A0J9XDN4_GEOCN61.609%5470.0Similar to Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(Alpha)-pyrophosphate synthetase OS=Geotrichum candidum GN=BN980_GECA11s01594g PE=4 SV=1
A0A060SZ17_BLAAD58.812%5220.0ARAD1A16302p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16302g PE=4 SV=1
A0A1E3PEG9_9ASCO55.744%5311.43e-180Ribose-phosphate pyrophosphokinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48045 PE=4 SV=1
MCA_03091_169.617%3394.85e-148MCA_03091_1
A0A167D847_9ASCO62.727%3301.13e-127Ribose phosphate diphosphokinase subunit PRS1 OS=Sugiyamaella lignohabitans GN=PRS1 PE=4 SV=1
UniRef50_A0A1J7JXH242.463%5442.81e-123Phosphoribosyl pyrophosphokinase n=1 Tax=Coniochaeta ligniaria NRRL 30616 TaxID=1408157 RepID=A0A1J7JXH2_9PEZI
Q5A4X7_CANAL84.000%2005.29e-126Ribose phosphate diphosphokinase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.969 PE=4 SV=1
Q6CER7_YARLI60.494%3241.82e-120YALI0B13552p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13552g PE=4 SV=1
KPR1_YEAST78.000%2003.09e-116Ribose-phosphate pyrophosphokinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRS1 PE=1 SV=1
A0A1E4TI29_9ASCO71.845%2063.72e-109Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_123561 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0373

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 524

Detailed signature matches

  1. Family IPR005946
    Ribose-phosphate diphosphokinase
    1. PF14572 (Pribosyl_s...)
    2. TIGR01251
  2. Domain IPR029057
    Phosphoribosyltransferase-like
    1. SSF53271 (PRTase-like)
  3. Domain IPR029099
    Ribose-phosphate pyrophosphokinase, N-terminal domain
    1. PF13793 (Pribosyltr...)
  4. Domain IPR000836
    Phosphoribosyltransferase domain
    1. cd06223 (PRTases_typeI)
  5. SITE IPR000842
    Phosphoribosyl pyrophosphate synthetase, conserved site
    1. PS00114 (PRPP_SYNTHASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SM01400 (Pribosyltr...)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd06223
  2. active site cd06223

Protein sequence

>MIA_02506_1
MRKSHVFVGSSHPELGQLICDRLGVEPGKCTLRKFSNGETSIEIGVSVRDEDVYVVQSGSADINDHIMELLILISGCRGG
SANKITAVIPCFPYAKQSKMKKHRGAITARMLANLLIMAGADHVITMDLHATQMQGFFSKPVDNLLAGPTLARWIRHNVP
DYSAAVIVSKNPGGTKRVTALADALKVNFAMIHTDRRRAQHKIPGRSGARPPALSTAATRKSPVSARTPSSGLSQGFSAS
DIAAEQEEQEADNEGPVKVVIDHANGTSTTAEPSTPPRIIPSTQTNEDEDDDVSDINTQSVHVARIVQGHVVNDDEYPED
EDDENDLFAKLRRDGAASGFTGPTGTVGEYGSESIYSEHALGGTGDAESSEDEDDGAYDHHAHDDFESHSGTPSEGGKHA
RTQEKVITLVGDVRGRTAILLDDMIDRAGSFVAAAELCYKNCGAKRVLVVATHAIFSGNSLEALDACPYIDQIVVTNTYP
IPAEKRARCKKLVVIDVSTILAECIRRNHHGESISALFEQLLLL

GO term prediction

Biological Process

GO:0009116 nucleoside metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0044249 cellular biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity

Cellular Component

None predicted.