Protein

MCA_03091_1

Length
561 amino acids

Browser: contigB:3351650-3353336-

RNA-seq: read pairs 3191, FPKM 70.2, percentile rank 72.7% (100% = highest expression)

Protein function

KEGG:K00948PRPS ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
EGGNOG:0PFQHFG04261.1ribose-phosphate pyrophosphokinase
SGD closest match:S000001664PRS1Ribose-phosphate pyrophosphokinase 1
CGD closest match:CAL0000189135orf19.969Ribose phosphate diphosphokinase subunit

Protein alignments

%idAln lengthE-value
MIA_02506_163.26%5770.0MIA_02506_1
A0A0J9XDN4_GEOCN87.98%2081e-125Similar to Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(Alpha)-pyrophosphate synthetase OS=Geotrichum candidum GN=BN980_GECA11s01594g PE=4 SV=1
A0A167D847_9ASCO90.45%1993e-125Ribose phosphate diphosphokinase subunit PRS1 OS=Sugiyamaella lignohabitans GN=PRS1 PE=4 SV=1
Q5A4X7_CANAL84.42%1991e-124Ribose phosphate diphosphokinase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.969 PE=4 SV=1
A0A060SZ17_BLAAD88.54%1924e-120ARAD1A16302p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16302g PE=4 SV=1
A0A1E3PEG9_9ASCO82.27%2031e-118Ribose-phosphate pyrophosphokinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48045 PE=4 SV=1
Q6CER7_YARLI84.34%1985e-117YALI0B13552p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B13552g PE=4 SV=1
UniRef50_Q6CER784.34%1981e-113YALI0B13552p n=7 Tax=Saccharomycetales TaxID=4892 RepID=Q6CER7_YARLI
KPR1_YEAST77.18%2067e-116Ribose-phosphate pyrophosphokinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRS1 PE=1 SV=1
A0A1E4TI29_9ASCO72.41%2032e-107Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_123561 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0322

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 561

Detailed signature matches

  1. Family IPR005946
    Ribose-phosphate diphosphokinase
    1. PF14572 (Pribosyl_s...)
    2. TIGR01251
  2. Domain IPR029057
    Phosphoribosyltransferase-like
    1. SSF53271 (PRTase-like)
  3. Domain IPR029099
    Ribose-phosphate pyrophosphokinase, N-terminal domain
    1. PF13793 (Pribosyltr...)
  4. Domain IPR000836
    Phosphoribosyltransferase domain
    1. cd06223 (PRTases_typeI)
  5. SITE IPR000842
    Phosphoribosyl pyrophosphate synthetase, conserved site
    1. PS00114 (PRPP_SYNTHASE)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SM01400 (Pribosyltr...)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd06223
  2. active site cd06223

Protein sequence

>MCA_03091_1
MRKSHVFVGTSHPELGQLICDRLGVEPGPCTLKKFSNGETSIEIGVSVRDEDVYVVQSGSSTINDHIMELLILISGCKGG
SANKITAVIPSFPYAKQSKMKKHRGAITARMLANLLIMAGADHVITMDLHATQMQGFFSKPVDNLLAGPTLARWIRHNVP
DYSAAVIVSKNPGGTKRVTALADALKVNFAMIHTDRRRTLVLPRTNGTINYSLNNGSKSLPKKQTTSSTPSSASASSSTT
TTSKQPSSNLSKGFSASDIHGEENVPVEFGDGSADGKVKVVVEHTNGTSHVLSNNTNGDSTKSPQTIISDDDDDSEEEEV
NGISTHSVHIARVVQGHVVPDNADIDAFTNGTTTPINEDDHEYGSNNLQDSVYSLASHGEHALGGTGDAESSDEDDDIAS
NNNYFNNAHGSSSNASSNNNNLSSNSNNTDPTSPAAVPPKEKVITLVGDVRGRTAIILDDMIDSPGSFIAAAELCYNNCG
AKRVIVVATHGIFSGNSLELLEECPCIDQIVVTNTYPIPLEKRQKCKKLVVIDISTIFAECIRRNHHGESISVLFEQLLT
I

GO term prediction

Biological Process

GO:0009116 nucleoside metabolic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0044249 cellular biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity

Cellular Component

None predicted.