Protein

MIA_02489_1

Length
642 amino acids

Browser: contig03:951783-953712-

Protein function

EGGNOG:0PGNTACL1ATP-citrate synthase subunit 1
SGD closest match:S000005668LSC1Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
CGD closest match:CAL0000179127LSC1Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

Protein alignments

%idAln lengthE-value
MCA_01645_196.106%6420.0MCA_01645_1
A0A0J9XIH0_GEOCN93.906%6400.0Similar to Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase OS=Geotrichum candidum GN=BN980_GECA18s02562g PE=4 SV=1
A0A167EVS4_9ASCO91.918%6310.0Succinate--CoA ligase (GDP-forming) subunit alpha OS=Sugiyamaella lignohabitans GN=LSC1 PE=4 SV=1
UniRef50_A0A167EVS491.918%6310.0Succinate--CoA ligase (GDP-forming) subunit alpha n=120 Tax=cellular organisms TaxID=131567 RepID=A0A167EVS4_9ASCO
Q6C3H5_YARLI88.801%6340.0YALI0E34793p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E34793g PE=4 SV=1
A0A060T543_BLAAD88.608%6320.0ARAD1B07414p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B07414g PE=4 SV=1
A0A1E3PJE7_9ASCO85.552%6160.0Citrate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ACL1 PE=4 SV=1
A0A1E4THM9_9ASCO84.516%6200.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_121736 PE=4 SV=1
SUCA_YEAST27.347%2451.75e-15Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LSC1 PE=1 SV=1
Q5A8X6_CANAL33.333%2011.05e-11Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LSC1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0592

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 642

Detailed signature matches

  1. Family IPR002020
    Citrate synthase
    1. SSF48256 (Citrate s...)
    2. PF00285 (Citrate_synt)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR003781
    CoA-binding
    1. PF02629 (CoA_binding)
    2. SM00881 (CoA_binding_2)
  4. Domain IPR016102
    Succinyl-CoA synthetase-like
    1. G3DSA:3.40.50...
  5. Domain IPR005811
    ATP-citrate lyase/succinyl-CoA ligase
    1. PF00549 (Ligase_CoA)
  6. Domain IPR016142
    Citrate synthase-like, large alpha subdomain
    1. G3DSA:1.10.58...
  7. Domain IPR016143
    Citrate synthase-like, small alpha subdomain
    1. G3DSA:1.10.23...
  8. SITE IPR017866
    Succinyl-CoA synthetase, beta subunit, conserved site
    1. PS01217 (SUCCINYL_C...)
  9. SITE IPR033847
    ATP-citrate lyase/succinyl-CoA ligase, conserved site
    1. PS01216 (SUCCINYL_C...)
  10. SITE IPR017440
    ATP-citrate lyase/succinyl-CoA ligase, active site
    1. PS00399 (SUCCINYL_C...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. PR01798 (SCOASYNTHASE)
  3. cd06100 (CCL_ACL-C)

Residue annotation

  1. citrylCoA binding ...
  2. oxalacetate bindin...
  3. active site cd06100
  4. coenzyme A binding...
  5. catalytic triad cd...

Protein sequence

>MIA_02489_1
MSEKMPYELFTNKTRAFVYGLQPRACQGMLDFDFICKREIPSVAGVIYPFGGQFVTKMYWGTKETLLPVYQQVEKAIAKH
PDVDVVVNFASSRSVYSSTLELLEYPQIKTIAIIAEGVPERRAREILYKAKKKGVTIIGPATVGGIKPGCFKIGNTGGMM
DNIVASKLYRPGSVAYVSKSGGMSNELNNIIAHTTDGVYEGIAIGGDRYPGTTFIDHILRYEADPNCKIIVLLGEVGGVE
EYRVIEAVKNGIVKKPIVAWAIGTIASKLKTEVQFGHAGSMANSNLETAVSKNAAMKAAGFYVPDTFEDLPETLAQVYDA
LVKKKVIVPEPEPEVPKIPIDYSWAQELGLIRKPAAFISTISDDRGQELLYAGIPISEVFKEDIGIGGVMSLLWFRRRLP
PYASKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVSGLLTIGERFGGALDGAANEFKNAFDKGLSPRQFVDSM
RKQNKLIPGIGHKVKSRNNPDFRVELVKEFVKKNFPATNLLDYALAVEEVTTSKKDNLILNVDGCVAVSFVDLMRSSGAF
TPEEVEEYLKNGVLNGLFVLGRSIGLIAHHLDQKRLKTGLYRHPWDDITYLVGQDAMQTTKRVEVDARGVSKAVSKKGGP
QK

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037 cofactor binding

Cellular Component

None predicted.