Protein
MCA_01645_1
Length
642 amino acids
Gene name: LSC1B
Description: Alpha subunit of succinyl-CoA ligase
Browser: contigA:5062996-5064925+
RNA-seq: read pairs 3859, FPKM 74.2, percentile rank 73.7% (100% = highest expression)
Protein function
| Annotation: | LSC1B | Alpha subunit of succinyl-CoA ligase | |
|---|---|---|---|
| KEGG: | K01648 | ACLY | ATP citrate (pro-S)-lyase [EC:2.3.3.8] |
| EGGNOG: | 0PGNT | ACL1 | ATP-citrate synthase subunit 1 |
| SGD closest match: | S000005668 | LSC1 | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial |
| CGD closest match: | CAL0000179127 | LSC1 | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02489_1 | 96.11% | 642 | 0.0 | MIA_02489_1 |
| A0A0J9XIH0_GEOCN | 94.35% | 637 | 0.0 | Similar to Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase OS=Geotrichum candidum GN=BN980_GECA18s02562g PE=4 SV=1 |
| A0A167EVS4_9ASCO | 91.04% | 636 | 0.0 | Succinate--CoA ligase (GDP-forming) subunit alpha OS=Sugiyamaella lignohabitans GN=LSC1 PE=4 SV=1 |
| UniRef50_A0A167EVS4 | 91.04% | 636 | 0.0 | Succinate--CoA ligase (GDP-forming) subunit alpha n=120 Tax=cellular organisms TaxID=131567 RepID=A0A167EVS4_9ASCO |
| Q6C3H5_YARLI | 88.89% | 630 | 0.0 | YALI0E34793p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E34793g PE=4 SV=1 |
| A0A060T543_BLAAD | 89.08% | 632 | 0.0 | ARAD1B07414p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B07414g PE=4 SV=1 |
| A0A1E3PJE7_9ASCO | 85.39% | 616 | 0.0 | Citrate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ACL1 PE=4 SV=1 |
| A0A1E4THM9_9ASCO | 84.35% | 620 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_121736 PE=4 SV=1 |
| SUCA_YEAST | 27.35% | 245 | 6e-16 | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LSC1 PE=1 SV=1 |
| Q5A8X6_CANAL | 32.34% | 201 | 8e-11 | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LSC1 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1103
Predicted cleavage: 25
Protein family membership
- Citrate synthase (IPR002020)
Domains and repeats
-
Domain
-
Domain
1
100
200
300
400
500
642
Detailed signature matches
no IPR
Unintegrated signatures
-
-
cd06100 (CCL_ACL-C)
Residue annotation
-
citrylCoA binding ...
-
oxalacetate bindin...
-
active site cd06100
-
coenzyme A binding...
-
catalytic triad cd...
Protein sequence
>MCA_01645_1 MTQKQPYELFNNKTRAFVYGLQPRACQGMLDFDFICKREIPSVAGVIYPFGGQFVTKMYWGTKETLLPVYQQVEKAIAKH PDVDVVVNFASSRSVYSSTLELLEYPQIKTIAIIAEGVPERRAREILYKAKKKGVTIIGPATVGGIKPGCFKIGNTGGMM DNIVASKLYRPGSVAYVSKSGGMSNELNNIIAHTTNGVYEGIAIGGDRYPGTTFIDHILRYEADPKCKIIVLLGEVGGVE EYRVIDAVKNGIIKKPIVAWAIGTIASKLKTEVQFGHAGSMANSTLETAVTKNAAMKDAGFFVPDTFEDLPETLAKVYDD LVKKKVIIPEPEPEAPKIPIDYSWAQELGLIRKPAAFISTISDDRGQELLYAGIPISEVFKEDIGIGGVMSLLWFRRRLP HYASKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVSGLLTIGDRFGGALDGAANEFKNAFDKGLSPRQFVDSM RKQNKLIPGIGHKVKSRNNPDFRVELVKEFVKKNFPATHLLDYALAVEEVTTSKKDNLILNVDGCVAVSFVDLMRSSGAF TPEEVEEYLKNGVLNGLFVLGRSIGLIAHHLDQKRLKTGLYRHPWDDITYLVGQDAVQTSKRVEVDAKGVSKAASKRAGP QK
GO term prediction
Biological Process
GO:0008152 metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037 cofactor binding
Cellular Component
None predicted.