MIA_02472_1

Protein

Length

2,079 amino acids

Protein function

EGGNOG:	0PGVB	FG05398.1	Cell division control protein
SGD closest match:	S000004301	CDC25	Cell division control protein 25
CGD closest match:	CAL0000178834	CDC25	Cell division control protein 25

Protein alignments

	%id	Aln length	E-value
MCA_01377_1	75.056%	445	0.0	MCA_01377_1
A0A0J9XAH7_GEOCN	62.528%	443	7.32e-173	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) OS=Geotrichum candidum GN=BN980_GECA07s05411g PE=4 SV=1
UniRef50_A0A0J9XAH7	62.528%	443	1.50e-169	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAH7_GEOCN
Q6C867_YARLI	51.685%	445	9.43e-128	YALI0D22286p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D22286g PE=4 SV=1
A0A161HLY5_9ASCO	50.112%	447	9.44e-122	Ras family guanine nucleotide exchange factor CDC25 OS=Sugiyamaella lignohabitans GN=CDC25 PE=4 SV=1
A0A060T6U2_BLAAD	47.401%	481	3.00e-115	ARAD1C23078p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C23078g PE=4 SV=1
A0A1E3PU83_9ASCO	44.850%	466	1.29e-106	Ras GEF OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49051 PE=3 SV=1
CDC25_CANAL	44.522%	429	5.68e-94	Cell division control protein 25 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC25 PE=4 SV=2
CDC25_YEAST	37.333%	450	3.51e-79	Cell division control protein 25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC25 PE=1 SV=1
A0A1E4TAP2_9ASCO	36.501%	463	1.08e-75	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13579 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3448
Predicted cleavage: 73

Protein family membership

None predicted.

Domains and repeats

Domain
462 - 538
SH3 domain (IPR001452)
1,653 - 1,787
Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
1,817 - 2,076
Ras guanine-nucleotide exchange factors catalytic domain (IPR001895)
Domain
1,638 - 2,065
Ras guanine nucleotide exchange factor domain (IPR023578)

1 200 400 600 800 1000 1200 1400 1600 1800 2079

Detailed signature matches

IPR001452

SH3 domain
1. PF00018 (SH3_1)
  
  480 - 525
  
  Pfam
  PF00018 (SH3_1)
2. SM00326 (SH3_2)
  
  477 - 532
  
  SMART
  SM00326 (SH3_2)
3. SSF50044 (SH3-domain)
  
  462 - 538
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
4. PS50002 (SH3)
  
  474 - 533
  
  PROSITE profiles
  PS50002 (SH3)
IPR023578

Ras guanine nucleotide exchange factor domain
1. SSF48366 (Ras GEF)
  
  1,638 - 2,065
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
IPR000651

Ras-like guanine nucleotide exchange factor, N-terminal
1. SM00229 (rasgefn_5)
  
  1,653 - 1,787
  
  SMART
  SM00229 (rasgefn_5)
2. cd06224 (REM)
  
  1,662 - 1,784
  
  CDD
  cd06224 (REM)
3. PS50212 (RASGEF_NTER)
  
  1,654 - 1,787
  
  PROSITE profiles
  PS50212 (RASGEF_NTER)
4. PF00618 (RasGEF_N)
  
  1,658 - 1,757
  
  Pfam
  PF00618 (RasGEF_N)
IPR001895

Ras guanine-nucleotide exchange factors catalytic domain
1. cd00155 (RasGEF)
  
  1,821 - 2,058
  
  CDD
  cd00155 (RasGEF)
2. PF00617 (RasGEF)
  
  1,826 - 2,009
  
  Pfam
  PF00617 (RasGEF)
3. SM00147 (RasGEF_3)
  
  1,819 - 2,063
  
  SMART
  SM00147 (RasGEF_3)
4. PS50009 (RASGEF_CAT)
  
  1,823 - 2,062
  
  PROSITE profiles
  PS50009 (RASGEF_CAT)
5. G3DSA:1.10.84...
  
  1,817 - 2,076
  
  GENE3D
  G3DSA:1.10.840.10 (G3DSA:1.10.840.10)
IPR019804

Ras guanine-nucleotide exchange factor, conserved site
1. PS00720 (RASGEF)
  
  1,976 - 2,008
  
  PROSITE patterns
  PS00720 (RASGEF)

no IPR

Unintegrated signatures

Coil

2,079 - 2,079

COILS
Coil (Coil)
G3DSA:1.20.87...

1,632 - 1,816

GENE3D
G3DSA:1.20.870.10 (G3DSA:1.20.870.10)
G3DSA:2.30.30.40

420 - 538

GENE3D
G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
mobidb-lite (disord...)

661 - 682

MobiDB Lite
mobidb-lite (disorder_prediction)

345 - 369

MobiDB Lite
mobidb-lite (disorder_prediction)

550 - 585

MobiDB Lite
mobidb-lite (disorder_prediction)

438 - 472

MobiDB Lite
mobidb-lite (disorder_prediction)

597 - 618

MobiDB Lite
mobidb-lite (disorder_prediction)

173 - 208

MobiDB Lite
mobidb-lite (disorder_prediction)

1,243 - 1,263

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 132

MobiDB Lite
mobidb-lite (disorder_prediction)

1,555 - 1,633

MobiDB Lite
mobidb-lite (disorder_prediction)

803 - 850

MobiDB Lite
mobidb-lite (disorder_prediction)

735 - 785

MobiDB Lite
mobidb-lite (disorder_prediction)

305 - 330

MobiDB Lite
mobidb-lite (disorder_prediction)

238 - 283

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

GTPase interaction...

1,673H

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,727K

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,731F

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,732R

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,735N

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,738K

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,739R

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,778Q

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,779I

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)

1,782Q

GTPase interaction site
1,673H, 1,727K, 1,731F, 1,732R, 1,735N, 1,738K, 1,739R, 1,778Q, 1,779I, 1,782Q
CDD
cd06224 (REM)
Ras interaction si...

1,855N

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,856K

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,857T

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,868I

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,869D

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,871F

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,872I

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,873Q

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,875S

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,876N

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,879T

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,880N

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,883A

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,916S

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,919M

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,920A

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,922I

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,923S

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,924A

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,926S

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,927S

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,928A

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,929T

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,931H

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,932R

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,952K

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,955M

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,960N

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,961F

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,962N

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,965R

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,978F

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,979F

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,980G

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,983L

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,984T

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,985D

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,987T

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,988F

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,989L

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,991D

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,992A

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,993N

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

1,994S

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

2,011K

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

2,015I

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

2,050D

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

2,053Y

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

2,054D

Ras interaction site
1,855N, 1,856K, 1,857T, 1,868I, 1,869D, 1,871F, 1,872I, 1,873Q, 1,875S, 1,876N, 1,879T, 1,880N, 1,883A, 1,916S, 1,919M, 1,920A, 1,922I, 1,923S, 1,924A, 1,926S, 1,927S, 1,928A, 1,929T, 1,931H, 1,932R, 1,952K, 1,955M, 1,960N, 1,961F, 1,962N, 1,965R, 1,978F, 1,979F, 1,980G, 1,983L, 1,984T, 1,985D, 1,987T, 1,988F, 1,989L, 1,991D, 1,992A, 1,993N, 1,994S, 2,011K, 2,015I, 2,050D, 2,053Y, 2,054D
CDD
cd00155 (RasGEF)

Protein sequence

>MIA_02472_1
MSFFRNSSPSGPSTARADQKLAPRAALHATNDNNNNSLNSNSSCNLAPASSSISPFAFSPATTTSYPSSPRPKSIANFKS
TPNSPSLFSSSSTTSAVSSDKPPVPLDDPHSNVPYTEHLSNHSSKKSATRSSSASIYSVNSSSKGARAFQRISSVASSAT
SSLFKTQLFGGSNCNNNSSSSSSKKQQNLSQENDGLFQRSNSTGSSTKFLKSKMNTAHKQDTFRSSPGSPAIPVNISFQQ
KTQQQQQQSSPLTSQQHALLSPHHNQQPLSTSSSPVQYPSSASHSPFIVPANVSTISDTPPAFITQQHRSRHPSVSSTHS
ISPVTSHQSFSKTFEPRALAAAAVAATSAPSNPPSTNQGTSSATLSSHSVIPPPILKTHMEQYTQFNANAPPPASNYPTC
HIASNQLPSPPFQSPDDSVTLEDSHQQQLVQILRTQQQQQFQPHSQAVHVTTPSSTTSFSIPDASTLPPPPSSEFIDTVI
ARFPFSSDSAYSLALKPGDVIKVLLKIEGWWDGVNSQGQRGWFPSNYTLPLSENQLQFLSNGAKPDVVSEQVSRSSSVGS
HSNLSQTPLRAVSSSSSLHSSSSARKDFDLPQASTAFAQQRAHQQLPPPLPPSLPEYSVPVSIQQPVAGSPDLINNFNSI
LNFSQSSPLSSSSFSSTSAAVASASGSSPSPSSSSHNIHNNAAITNPGVTAAAGVANAPPGTYFPSSLDPKTTATYQATI
DQLDPLVVSSAVAPKQFSTTQQQQQSQHLQLSQHPHPPPNHVTLNPATASAAQTPSNLTPSTFPGRRYNPVFNNVFESTP
IQPDMSSLSSRSLGSTANCNDGSRKGSVVSFMSSNSRNDDSEISFSEPPNLSDYRFVEGDALLKLSQSDSNSQLSEHRTF
WNPYSNNQAKLFFYNPQLKLITNNIPFESVSKTQAAALASSPLPTTCPGPKDLASVSEHPTISSTSLDSGNQVSPLIIKS
SGDPYKELLYKYSQKNYEYKNRTRSDSEYSITSLSSSLSIPFKYTDNIEHLKTWSSIVGRLELIASNMLSSLSSRDFHGI
SNSYESFSNIIAHISYMSGIPPSTVPASIPSNREISRTYRRMVTCLSKLGLSADIAKDKSEAFTEFLKKPRSSSVISTHS
LGSLSQSSGSPLGGDRKFSIISELSESGEDADPYKLCARDTKMLLKCTKAFIKQFKQTLRTGSVSAASGNNSSFGALPVS
SSSEYANSEFSNDDSASITSRGSVDSQASISYPVKRFRAGTWSNTNISPTSPNGASGGPRPPRRASIVPLEAYDSIIPLD
YVVVTVLEHQRSMVLNILRQIFSLINNKRPYNSTAKTSSTSTSSLPNNAPYHVAPAGSSTSFSELKAAATVPSSSEKSYF
DMKEDRRVLFVSSLNSLVAIVTNISNLLESLDLSVYQSCMHSEHKHTGDCSNFYSQVASPSNVQSLILLYDFLNVKQTIY
DELLGFLAAVQSNDILEKDFIEHFANTLEATKVSSTLVTMSSSTDLNKAASNLTSLSNTPPSTSKFMSTNHEITEGAKSC
ANDHERIIKMRVMEMGIAVDAVVQTAALLAEERPQTPFGDTEGPTPGSAASAPTFSEDNQYPLGYYQRDSSHSQIQSSGP
NSNRSRSNSVAGLEGSGGGYSMVSSNSSASKGSSKAEMPWFLKVDHADELILDGKNHVKGGTLVALVERLTQHDSRDAAF
IDAFLLTFRSMMSPQQLFQMLLNRYTIQPPAGLTSDEFNLWTERKQKLIRFRVINILKRWLDEFWYEDPNSKPIQILLQS
MMNFTVELKHQNSSVYEQIRNQIEIKMKMDTATHTRIVQNPPLTPPVPILPRNLKKIKLSDLDPLELARQLTLREFKLFE
QITPFECLTRRQSKNKTRNNTLEGTPHIDDFIQNSNSLTNWVAAMILSYTEPKKRAQAIKYFTNVAEYCRQHNNFSSMMA
IISALSSATIHRLKKTWVLVSEKTMFVLENMKRIMNSSRNFNEYRDIIRLVVPPVIPFFGVCLTDLTFLEDANSDYLHDD
PNMINFSKRMKSADIISRIMDYQVKHYVFQEVPEIQNLLTAGYSQAEPIDSQYDLSLTLEPRVNTDERVTKLLEETGFL

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Cellular Component