MCA_01377_1

Protein

Length

1,833 amino acids

RNA-seq: read pairs 2389, FPKM 16.1, percentile rank 35.6% (100% = highest expression)

Protein function

KEGG:	K03099	SOS	son of sevenless
EGGNOG:	0PGVB	FG05398.1	Cell division control protein
CGD closest match:	CAL0000178834	CDC25	Cell division control protein 25

Protein alignments

	%id	Aln length	E-value
MIA_02472_1	75.40%	443	0.0	MIA_02472_1
A0A0J9XAH7_GEOCN	50.48%	727	0.0	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) OS=Geotrichum candidum GN=BN980_GECA07s05411g PE=4 SV=1
UniRef50_A0A0J9XAH7	50.48%	727	0.0	Similar to Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XAH7_GEOCN
Q6C867_YARLI	53.48%	445	5e-129	YALI0D22286p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D22286g PE=4 SV=1
A0A161HLY5_9ASCO	53.44%	451	1e-131	Ras family guanine nucleotide exchange factor CDC25 OS=Sugiyamaella lignohabitans GN=CDC25 PE=4 SV=1
A0A060T6U2_BLAAD	51.24%	484	5e-125	ARAD1C23078p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C23078g PE=4 SV=1
A0A1E3PU83_9ASCO	45.71%	466	2e-111	Ras GEF OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49051 PE=3 SV=1
CDC25_CANAL	44.29%	429	9e-92	Cell division control protein 25 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC25 PE=4 SV=2
A0A1E4TAP2_9ASCO	37.80%	463	2e-80	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_13579 PE=4 SV=1
YL016_YEAST	33.33%	444	2e-61	Putative truncated guanine nucleotide exchange factor SDC25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SDC25 PE=5 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2105
Predicted cleavage: 28

Protein family membership

None predicted.

Domains and repeats

Domain
217 - 287
SH3 domain (IPR001452)
1,407 - 1,542
Ras-like guanine nucleotide exchange factor, N-terminal (IPR000651)
1,565 - 1,829
Ras guanine-nucleotide exchange factors catalytic domain (IPR001895)
Domain
1,387 - 1,819
Ras guanine nucleotide exchange factor domain (IPR023578)

1 200 400 600 800 1000 1200 1400 1600 1833

Detailed signature matches

IPR001452

SH3 domain
1. SM00326 (SH3_2)
  
  224 - 280
  
  SMART
  SM00326 (SH3_2)
2. PF14604 (SH3_9)
  
  228 - 276
  
  Pfam
  PF14604 (SH3_9)
3. SSF50044 (SH3-domain)
  
  217 - 287
  
  SUPERFAMILY
  SSF50044 (SH3-domain)
4. PS50002 (SH3)
  
  221 - 281
  
  PROSITE profiles
  PS50002 (SH3)
IPR023578

Ras guanine nucleotide exchange factor domain
1. SSF48366 (Ras GEF)
  
  1,387 - 1,819
  
  SUPERFAMILY
  SSF48366 (Ras GEF)
IPR000651

Ras-like guanine nucleotide exchange factor, N-terminal
1. SM00229 (rasgefn_5)
  
  1,407 - 1,542
  
  SMART
  SM00229 (rasgefn_5)
2. cd06224 (REM)
  
  1,416 - 1,538
  
  CDD
  cd06224 (REM)
3. PS50212 (RASGEF_NTER)
  
  1,408 - 1,542
  
  PROSITE profiles
  PS50212 (RASGEF_NTER)
4. PF00618 (RasGEF_N)
  
  1,412 - 1,512
  
  Pfam
  PF00618 (RasGEF_N)
IPR001895

Ras guanine-nucleotide exchange factors catalytic domain
1. cd00155 (RasGEF)
  
  1,575 - 1,812
  
  CDD
  cd00155 (RasGEF)
2. PF00617 (RasGEF)
  
  1,580 - 1,763
  
  Pfam
  PF00617 (RasGEF)
3. SM00147 (RasGEF_3)
  
  1,573 - 1,817
  
  SMART
  SM00147 (RasGEF_3)
4. PS50009 (RASGEF_CAT)
  
  1,577 - 1,816
  
  PROSITE profiles
  PS50009 (RASGEF_CAT)
5. G3DSA:1.10.84...
  
  1,565 - 1,829
  
  GENE3D
  G3DSA:1.10.840.10 (G3DSA:1.10.840.10)
IPR019804

Ras guanine-nucleotide exchange factor, conserved site
1. PS00720 (RASGEF)
  
  1,730 - 1,762
  
  PROSITE patterns
  PS00720 (RASGEF)

no IPR

Unintegrated signatures

Coil

1,833 - 1,833

COILS
Coil (Coil)
G3DSA:2.30.30.40

250 - 585

GENE3D
G3DSA:2.30.30.40 (G3DSA:2.30.30.40)

41 - 249

GENE3D
G3DSA:2.30.30.40 (G3DSA:2.30.30.40)
cd11883 (SH3_Sdc25)

225 - 275

CDD
cd11883 (SH3_Sdc25)
mobidb-lite (disord...)

1 - 28

MobiDB Lite
mobidb-lite (disorder_prediction)

1,048 - 1,104

MobiDB Lite
mobidb-lite (disorder_prediction)

181 - 216

MobiDB Lite
mobidb-lite (disorder_prediction)

431 - 451

MobiDB Lite
mobidb-lite (disorder_prediction)

937 - 958

MobiDB Lite
mobidb-lite (disorder_prediction)

353 - 399

MobiDB Lite
mobidb-lite (disorder_prediction)

481 - 537

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

peptide ligand bin...

230S

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

232Y

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

235D

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

239S

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

257G

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

258W

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

272P

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

274N

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)

275Y

peptide ligand binding site
230S, 232Y, 235D, 239S, 257G, 258W, 272P, 274N, 275Y
CDD
cd11883 (SH3_Sdc25)
GTPase interaction...

1,427H

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,481K

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,485L

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,486R

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,489N

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,492K

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,493K

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,532Q

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,533I

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)

1,536Q

GTPase interaction site
1,427H, 1,481K, 1,485L, 1,486R, 1,489N, 1,492K, 1,493K, 1,532Q, 1,533I, 1,536Q
CDD
cd06224 (REM)
Ras interaction si...

1,609S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,610K

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,611T

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,622I

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,623D

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,625F

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,626I

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,627R

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,629S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,630N

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,633T

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,634N

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,637A

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,670S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,673M

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,674A

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,676I

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,677S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,678A

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,680S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,681S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,682A

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,683T

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,685H

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,686R

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,706N

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,709M

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,714N

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,715F

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,716S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,719R

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,732F

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,733F

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,734G

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,737L

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,738T

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,739D

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,741T

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,742F

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,743L

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,745D

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,746A

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,747N

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,748S

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,765K

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,769I

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,804D

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,807Y

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

1,808D

Ras interaction site
1,609S, 1,610K, 1,611T, 1,622I, 1,623D, 1,625F, 1,626I, 1,627R, 1,629S, 1,630N, 1,633T, 1,634N, 1,637A, 1,670S, 1,673M, 1,674A, 1,676I, 1,677S, 1,678A, 1,680S, 1,681S, 1,682A, 1,683T, 1,685H, 1,686R, 1,706N, 1,709M, 1,714N, 1,715F, 1,716S, 1,719R, 1,732F, 1,733F, 1,734G, 1,737L, 1,738T, 1,739D, 1,741T, 1,742F, 1,743L, 1,745D, 1,746A, 1,747N, 1,748S, 1,765K, 1,769I, 1,804D, 1,807Y, 1,808D
CDD
cd00155 (RasGEF)

Protein sequence

>MCA_01377_1
MHKTQQVSSSSASNSSTSSNPADSLRSSANSHIQYVPTSINPAVSSQNYNSSPVEPCNQNISYRPYIEIPIQNLSTSFQG
MEIASDPNIQHLSYSNQNHKVKRSSSLNTGLTNPNSPLPPIPTFLTSRFDPNFNQIHIIQAPYNHTGIVNSSSPISRQMM
TATLDPMMYSNLRSNAPATANVIPNFSEPIPQSPTSHHESQNKPTTSTPTDSNFPVPAINNVVETVVALSSYSSDKQFSL
SFKKGDLIKVLVKLESGWWDGINPKGQRGFFPSNYTVPLPSRTTSLRSKHQHIFNNQDEDDSDDDDNISLSDQTTAIMPT
LHHHHPKEVNSSQEKMQSLTQIFNTATPLDFADGPTAVDHAPGASLENKNLNSSTLHPPLSSSATTTTTTSSNNTTSGSF
SPYSISPFSSNSSSSPQSAFSPVTASIDHIDPLSSFPQSGSSVESSPSKAHHNISKINIHPYSPASSHIISTPTSSTFSQ
FSSPKLAGSSLASQTTNNSTISFKPNPINTSNSMTTAPSAPSAPSAPSAPSSSSATNSILNRRLNPAFNNVFEASQYYPD
NASITSSRTGGETGSRKGSIVSFMSSNGLNDDSEISFSDPSNLSDFRFIDSNALSKLSLDSHSTVSEHKTLWNPYTNDQA
RLFFYNPSLKLVTDALPFEAVSNTMAANMASNHHPNNSNKCLGPGDIALVGDHPIISLSTENRPQDTTNPILQSSGDPYK
ELLIKHQRSFQATRARLQSTDSIISFNSLSSSLSIPFKYSDNLEHLKTWSSITGRLELYTSNMLQNLNDHDGPGIASAFE
ALASLIAHISYMSGVPPGTVPATIPSNRDISKAYRSMVTSLSKLGLSADICQDKSEAFSELLKKPRSSSIISSQTSLSHS
SSGQSVSNERKFSIISELSEYGKDIDPYKLCARETKTLMKTTKHYIKQFKRSLKSSIEGNDSATDDSVSVTSRSSSDSQS
SISYSVKQFRAGTWANVNISAVPPQSVAGMGRPPRRKSIFPLEAYDSIIPLDNEVITVLEYQRTMVFNILRQIFSLINKS
CNGTTPNNSSHFTAHSNASSNSLTSTNSGKSPQTSGNPSTTPSSIRPNHHDFNNSTTSANENQNYHQGEIREDKRVLFVS
SLNTLVAIVTNMSNLLESLDLLPYQAKPITDSRRPAAASSANGSSYSLYTPTNVPCLVLLYDFVNVRQTLYEELMRLLYA
VQNSDIFERSYIESFAAALESMASTSTVSGVNSSNNSIRSSSSLSLSSPAIAAATAAAKSNSNSIRRTILTSANIPPKST
ENLKPTLSTADSEQIIKMRVMELGVVVDAVVQTASLLAEEKPIVNPQYDGINSSSTSIQASIQDPSLFYADSSRQPRSRS
SSLSYSVNSFAMSTNTTSSTNNVNYNTPRDDLPWFLRADYADEIIYDAKNSVRGGTLPALIERLTQHDSRDSAFNSAFLL
TFRSFTSPQKLFESLVGRYGIQPPEGLSPNEYTLWSERKQKPIRLRVANILKKWLEEYWFEDPHSKQIQSLLQSMLTFTV
ELEHQKSPGWQQIRKQIEMKMKMDYTIHRRIVQNQPTLPPTPILPKNLKKIKLSDLDPLELARQLTLREYKLFVKITPYE
CLTRRQSKSKTRHNTLEGTPYIDAFIRNSNNLTNWVAAMILSYSDPKKRAQAIKYFTNVAEYCRQCNNFSSMMAIISALS
SATIHRLKKTWELVPEKTNYFLQNMNRLMNSSRNFSEYRDILRLVSPPVIPFFGVYLTDLTFLEDANSDFLQESAKLINF
SKRMKSADIIRDIMQYQIVPYVYKEIPEIQTLLTNGYTQAQPIDAQYDLSLELEPRANSDERVTKLLAETGFL

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Cellular Component