Protein

MIA_02427_1

Length
696 amino acids

Browser: contig03:759006-761147-

Protein function

EGGNOG:0PHBWMLH3DNA mismatch repair protein
SGD closest match:S000006085MLH3DNA mismatch repair protein MLH3
CGD closest match:CAL0000176790MLH3Mismatch repair protein

Protein alignments

%idAln lengthE-value
MCA_04177_142.898%7041.17e-176MCA_04177_1
A0A0J9XGF4_GEOCN33.380%7071.24e-111Similar to Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination OS=Geotrichum candidum GN=BN980_GECA15s00087g PE=4 SV=1
UniRef50_A0A0J9XGF433.380%7072.54e-108Similar to Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGF4_GEOCN
MLH3_YEAST26.210%7441.92e-45DNA mismatch repair protein MLH3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MLH3 PE=1 SV=1
A0A1E3PMY5_9ASCO34.109%2581.11e-37Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82502 PE=4 SV=1
A0A167CWJ8_9ASCO33.745%2436.15e-34Mismatch repair protein MLH3 OS=Sugiyamaella lignohabitans GN=MLH3 PE=4 SV=1
A0A1D8PFX1_CANAL34.404%2185.90e-31Mismatch repair protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MLH3 PE=4 SV=1
A0A060TAH0_BLAAD38.164%2074.33e-24ARAD1D19140p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D19140g PE=4 SV=1
Q6CCR3_YARLI32.870%2163.72e-19YALI0C07260p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C07260g PE=4 SV=1
A0A1E4TBV0_9ASCO25.822%2133.13e-10Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3853 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1002

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 696

Detailed signature matches

  1. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. SSF55874 (ATPase do...)
  2. Domain IPR014790
    MutL, C-terminal, dimerisation
    1. SM00853 (MutL_C_2)
    2. PF08676 (MutL_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF13589 (HATPase_c_3)
  2. SSF118116 (DNA mism...)
  3. cd00075 (HATPase_c)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MIA_02427_1
MNTQHVEPSIKVLPDSLALSITSQANITSLCECTIELISNSVDANATFISVIFDIERLSVRVSDNGYGILPSDLKKIALP
RHSSKWTLSGPLQTIGFKGSALASIASLSVLTVTSRHLTQAAAKSIRISYNHRSNVYTPRDFGSNHGTLIVVSGLFSRLP
VRKKHLHEIPVSLHIESLKRSILPVAIAKPHVTISVHDSNNKSLLYIPSVTTNLIPRHVVTLRAIYGTYIINRWQTVHTV
VNGFDVRGTIAFDPVRTKLAQHIVVNSKRLENFEVYKKLNNLFTVLGSSRFKDFGLFMVYILEVNFKCSFEEDVDALFAD
DISSETLDFITNLLSVVVKKFLKKHGYLLNKEKKTEELKLAKYQNKNLTKINTDMLIHSSSRTARVNRNELEGRLNNDHN
NPTIEHRVCRFKKHRISMPISKQCEENSNLKFTLPSPELTNNYNPDLSKYFYSNNQSKNGFDLTTLEKKFTKDDLISIKF
ISQVDAKFLLVTINLTSLSGPQKCLAIIDQHAADERVKLETLFVETTITALANSSTPLAHPVHFALSEMEHQVLTESIAL
FRQFGITYHLSSEKWKKPFVLLTHVPEIALRKIIPTTETLDTTFAHKLLLGHINDICEHRATSSIPNNSVHWSVAVRSYP
VALIEILQLKACRSAIMFGDLLTSEKCEILISNLSKCMFPFQCAHGRPSMIPLIDI

GO term prediction

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.