Protein

MCA_04177_1

Length
693 amino acids

Gene name: MLH3

Description: DNA mismatch repair protein MLH3

Browser: contigC:2281337-2283419+

RNA-seq: read pairs 1083, FPKM 19.3, percentile rank 40.5% (100% = highest expression)

Protein function

Annotation:MLH3DNA mismatch repair protein MLH3
KEGG:K08739MLH3 DNA mismatch repair protein MLH3
EGGNOG:0PHBWMLH3DNA mismatch repair protein
SGD closest match:S000006085MLH3DNA mismatch repair protein MLH3
CGD closest match:CAL0000176790MLH3Mismatch repair protein

Protein alignments

%idAln lengthE-value
MIA_02427_143.12%6988e-173MIA_02427_1
A0A0J9XGF4_GEOCN35.64%6791e-118Similar to Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination OS=Geotrichum candidum GN=BN980_GECA15s00087g PE=4 SV=1
UniRef50_A0A0J9XGF435.64%6792e-115Similar to Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGF4_GEOCN
A0A167CWJ8_9ASCO29.30%6111e-49Mismatch repair protein MLH3 OS=Sugiyamaella lignohabitans GN=MLH3 PE=4 SV=1
MLH3_YEAST26.07%7212e-46DNA mismatch repair protein MLH3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MLH3 PE=1 SV=1
A0A1E3PMY5_9ASCO37.98%2582e-42Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82502 PE=4 SV=1
A0A1D8PFX1_CANAL32.58%2212e-28Mismatch repair protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MLH3 PE=4 SV=1
A0A060TAH0_BLAAD33.07%2542e-24ARAD1D19140p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D19140g PE=4 SV=1
Q6CCR3_YARLI32.57%2187e-23YALI0C07260p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C07260g PE=4 SV=1
A0A1E4TBV0_9ASCO27.27%2203e-16Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3853 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1363

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 693

Detailed signature matches

  1. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. SSF55874 (ATPase do...)
  2. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  3. Domain IPR014790
    MutL, C-terminal, dimerisation
    1. SM00853 (MutL_C_2)
    2. PF08676 (MutL_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PF13589 (HATPase_c_3)
  2. SSF118116 (DNA mism...)
  3. cd00075 (HATPase_c)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MCA_04177_1
MEIQPKVIKPIPEALSQNVNSQVNLSSIQKCVIELVNNSIDANATNISIVIDIRRLSIKVTDNGEGISYENLQNIAKFCH
TAKWIEEEKPLLTIGYKGLGLASIASLSSVVITSRYQQDKSTYSVRINFGERSPVYKSTEPKSSHGTTISISSLFSTVPV
RKKHILSQPDSSQIESLKRDLVPIVLSKPQVTISIHDFSNKSFLYIPSAALSTTPRDISTLKAVHGIHVATRWQTVHAKV
KEVNVTGTIAIDPIRGRQAQYIIINNYRLEDISIYNEINAAFSSILPPTSSQEQSYFMVYVFNVTYPIVFSKISSAAFNL
EPTTEQIQYVKKLILTLISKFLQAQGLEGNLKRRKQQAKPPKPKAPRKDPTDILAKSNSRYAFFDRNEHLGRVTVTQKKD
YALCESHGNSQNKPFRLSLKPRPMERIKIQHPSSPPPEQLDLGPTSSKYFSALGTDYRLEKKFHRSDLKSIQFISQIDKK
FLMVNVYIKENNGKCLAVIDQHSADERVMLEKFFNEITSKSLQETATPLAYPLKIYLSEDEYKLLSEYYNLFRQFGILFS
LGSTRSHSKEGKMLFLTLTHVPELAFRKVSPSTDQINKDFAERLVLGYARDLMTKKCSLLPIDHSLNWTINIRNYPVALV
ELFQSKACRSAIKFGDELTKEQCITLIDKLSNCMFPFQCAHGRPSLVPLMDLS

GO term prediction

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.