Protein

MIA_02425_1

Length
447 amino acids

Browser: contig03:752187-753784-

Protein function

EGGNOG:0PKBHPDX1pyruvate dehydrogenase complex
SGD closest match:S000003425PDX1Pyruvate dehydrogenase complex protein X component, mitochondrial
CGD closest match:CAL0000179519PDX1Pdx1p

Protein alignments

%idAln lengthE-value
MCA_01581_152.361%4665.59e-132MCA_01581_1
A0A0J9XJA6_GEOCN47.768%4487.14e-112Similar to Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex OS=Geotrichum candidum GN=BN980_GECA20s01671g PE=4 SV=1
UniRef50_A0A0J9XJA647.768%4481.46e-108Similar to Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJA6_GEOCN
A0A167CM96_9ASCO40.716%4474.11e-98Pdx1p OS=Sugiyamaella lignohabitans GN=PDX1 PE=4 SV=1
A0A060T5B7_BLAAD43.056%4321.69e-88ARAD1B09680p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B09680g PE=4 SV=1
A0A1E3PTE9_9ASCO37.013%4627.90e-71Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49171 PE=4 SV=1
Q6CF67_YARLI38.228%4294.06e-70YALI0B09845p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B09845g PE=4 SV=1
Q5AKV6_CANAL44.262%2446.73e-56Pdx1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDX1 PE=4 SV=1
A0A1E4TE75_9ASCO45.024%2111.34e-48Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20355 PE=4 SV=1
ODPX_YEAST39.600%2501.04e-45Pyruvate dehydrogenase complex protein X component, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDX1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9698
Predicted cleavage: 27

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 447

Detailed signature matches

  1. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  2. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  3. Domain IPR004167
    E3-binding domain
    1. SSF47005 (Periphera...)
    2. G3DSA:4.10.32...
    3. PF02817 (E3_binding)
  4. SITE IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. cd06849 (lipoyl_domain)
  3. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction sur...
  2. lipoyl attachment ...

Protein sequence

>MIA_02425_1
MSLLRSTLFVSRHCGTRAFTTTGARLVASNFGMPAMSPTMTEGGIVDWKFKEGDSFNAGDILLEIETDKAQIDVEAQDDG
ILAKVYIPSGTTGIPVGKTIAVLAEPGDDLKTLEIPKPEEGSSGPSSVTTPAPAAASSSSEAPEQPKGQTPTPSSGTPES
SNEAGTGAITTKANPSQTLSPSVLALALDNNLTKQDVLDKVPASGPKGRVLKGDILAFLGKVPRADVDSIVNSIQRLQHL
DLSKINIKKPTASTPAATAAPTAPKVETSEKSEKAPAPKKPEVIQPPAPTVLSAFFTLGSISTLQKSLETGLKIAPPSAK
LLVEKASKRAIKDSNALYAARRAKTVLFDPVFEEIIAPNTHGQAPFVVSFKYPTAPLASAVSKSDIYDGFLSKKSLSPKK
SAQVAPSELLKVEVTLNSKYPGAPEKAKIYIDQLGFYLSQGTGELIL

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

None predicted.