Protein

MCA_01581_1

Length
453 amino acids

Gene name: PDX1

Description: Pyruvate dehydrogenase complex protein X component, mitochondrial

Browser: contigA:4888143-4889749-

RNA-seq: read pairs 13624, FPKM 370.8, percentile rank 93.1% (100% = highest expression)

Protein function

Annotation:PDX1Pyruvate dehydrogenase complex protein X component, mitochondrial
EGGNOG:0PKBHPDX1pyruvate dehydrogenase complex
SGD closest match:S000003425PDX1Pyruvate dehydrogenase complex protein X component, mitochondrial
CGD closest match:CAL0000179519PDX1Pdx1p

Protein alignments

%idAln lengthE-value
MIA_02425_153.15%4611e-133MIA_02425_1
A0A0J9XJA6_GEOCN50.00%4342e-116Similar to Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex OS=Geotrichum candidum GN=BN980_GECA20s01671g PE=4 SV=1
UniRef50_A0A0J9XJA650.00%4345e-113Similar to Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJA6_GEOCN
A0A167CM96_9ASCO45.00%4404e-100Pdx1p OS=Sugiyamaella lignohabitans GN=PDX1 PE=4 SV=1
A0A060T5B7_BLAAD41.99%4432e-87ARAD1B09680p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B09680g PE=4 SV=1
A0A1E3PTE9_9ASCO41.01%4344e-80Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49171 PE=4 SV=1
Q6CF67_YARLI51.50%2338e-60YALI0B09845p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B09845g PE=4 SV=1
Q5AKV6_CANAL49.38%2432e-55Pdx1p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDX1 PE=4 SV=1
A0A1E4TE75_9ASCO49.75%2031e-52Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20355 PE=4 SV=1
ODPX_YEAST43.18%2202e-47Pyruvate dehydrogenase complex protein X component, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDX1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9782
Predicted cleavage: 32

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 453

Detailed signature matches

  1. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  2. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  3. Domain IPR004167
    E3-binding domain
    1. SSF47005 (Periphera...)
    2. G3DSA:4.10.32...
    3. PF02817 (E3_binding)
  4. SITE IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. cd06849 (lipoyl_domain)
  8. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction sur...
  2. lipoyl attachment ...

Protein sequence

>MCA_01581_1
MSLLRAATLFGKPAIAATIRHRAFSSTSYKLVASNFGMPAMSPTMTEGGIVEWKVKEGEAFSAGDILLEIETDKAQIDVE
AQEDGILAKIYVPSGTTGIPVGKTIGVLAEADDDLSTLEIPKPVEGKSPEESIAASEPEPESKPAPSEPKESSAPSTSSE
KSPSSSHATKANPKQTLSPSVLSLALDNNLTKEEVLEKVPASGPKGRVLKGDILAYLGKIPRSDVDSLADTIEKWQHLDL
SNITIKKAQPSAPSSTPTPAKDVAASAAPSSKTETPSEQPPKKKAPEPKPKLVLNSVYTLAEINNLKQTLDTTIGTSASA
KSLVEKASKLALRDSIKLSKSVQAKKSVLIDPIFEELLAPSVSSLAGKKPFSVSIKYPQTSSSKLAFSSSSSNDFYDDLL
GGVGRKSAVVPSSELLTVDVTVDESYPGGAAKAQIYLDRLGYYLSQGKGELIL

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

None predicted.