Protein

MIA_02420_1

Length
453 amino acids

Browser: contig03:744843-746205+

Protein function

EGGNOG:0PH84FOL3Folylpolyglutamate synthase
SGD closest match:S000004719FOL3Dihydrofolate synthetase
CGD closest match:CAL0000182677orf19.6908Dihydrofolate synthetase

Protein alignments

%idAln lengthE-value
MCA_01869_155.677%4585.53e-171MCA_01869_1
A0A0J9X535_GEOCN48.791%4551.67e-128Dihydrofolate synthetase OS=Geotrichum candidum GN=BN980_GECA02s08007g PE=3 SV=1
UniRef50_A0A0J9X53548.791%4553.41e-125Dihydrofolate synthetase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X535_GEOCN
A0A161HHH5_9ASCO47.033%4554.66e-125Dihydrofolate synthetase OS=Sugiyamaella lignohabitans GN=FOL3 PE=3 SV=1
A0A1E3PQM9_9ASCO44.396%4554.02e-115Dihydrofolate synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48416 PE=3 SV=1
A0A060T765_BLAAD43.973%4483.71e-112ARAD1C26158p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26158g PE=4 SV=1
Q6CHD4_YARLI42.081%4421.81e-101YALI0A10032p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10032g PE=4 SV=1
A0A1E4TA80_9ASCO41.593%4523.00e-94Dihydrofolate synthetase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3313 PE=3 SV=1
A0A1D8PQV5_CANAL39.348%4604.95e-88Dihydrofolate synthetase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6908 PE=3 SV=1
FOLD_YEAST37.719%4563.62e-85Dihydrofolate synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8770
Predicted cleavage: 66

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 453

Detailed signature matches

  1. Family IPR001645
    Folylpolyglutamate synthetase
    1. PIRSF001563 (Folylp...)
  2. Domain IPR013221
    Mur ligase, central
    1. G3DSA:3.40.11...
    2. SSF53623 (MurD-like...)
  3. Domain IPR004101
    Mur ligase, C-terminal
    1. SSF53244 (MurD-like...)
  4. SITE IPR018109
    Folylpolyglutamate synthetase, conserved site
    1. PS01012 (FOLYLPOLYG...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.90.19...

Protein sequence

>MIA_02420_1
MGIDLGLRRISQLLALLGNPHKSWYSIHVAGTNGKGSVCAYLTSVFQSASIRSGRFTSPHLINRWDSITIDGQSVSETEF
LTVEAAVRMADSENNIGATEFELLTAVAFEIFARQHVRIAVVEVGLGGRLDATNILESSGQLCPSKITVGKQRGQDKGVL
ATVITKIGLDHQSFLGNTLGEIAFQKAGIIKPGVTCVVDFTNADEVLSVVRLVAEENKSRLISASYYQSDNSYLVDTKSW
GSFNTKLTPLLGNYQKANLACALKTLDTLTEWFPQELKDRTTIEQGIKMTQWPGRLQWVDLNLPGVKVPVRVLVDGAHNP
QAADELSEFLESNIRPTNKSINFVIAFTKGKNYKDIIKKVVKKGDSVVATDFDSVDGMPWISSCSAQDTADTVSKYVDGV
LVRAIPSNSEGGQMNAIAESYISGLKSGVQPQIVVFGSLYLVGKILDEHRKMK

GO term prediction

Biological Process

GO:0009058 biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process

Molecular Function

GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity

Cellular Component

None predicted.