Protein

MCA_01869_1

Length
453 amino acids

Gene name: FOL3

Description: Dihydrofolate synthetase

Browser: contigA:5729181-5730543-

RNA-seq: read pairs 1409, FPKM 38.3, percentile rank 59.4% (100% = highest expression)

Protein function

Annotation:FOL3Dihydrofolate synthetase
KEGG:K20457DHFS dihydrofolate synthase [EC:6.3.2.12]
EGGNOG:0PH84FOL3Folylpolyglutamate synthase
SGD closest match:S000004719FOL3Dihydrofolate synthetase
CGD closest match:CAL0000182677orf19.6908Dihydrofolate synthetase

Protein alignments

%idAln lengthE-value
MIA_02420_155.68%4582e-173MIA_02420_1
A0A161HHH5_9ASCO44.49%4454e-126Dihydrofolate synthetase OS=Sugiyamaella lignohabitans GN=FOL3 PE=3 SV=1
UniRef50_A0A161HHH544.49%4451e-122Dihydrofolate synthetase n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A161HHH5_9ASCO
A0A0J9X535_GEOCN46.55%4491e-124Dihydrofolate synthetase OS=Geotrichum candidum GN=BN980_GECA02s08007g PE=3 SV=1
A0A060T765_BLAAD42.19%4483e-115ARAD1C26158p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C26158g PE=4 SV=1
A0A1E3PQM9_9ASCO44.79%4512e-113Dihydrofolate synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48416 PE=3 SV=1
Q6CHD4_YARLI39.78%4454e-107YALI0A10032p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10032g PE=4 SV=1
A0A1E4TA80_9ASCO40.35%4569e-99Dihydrofolate synthetase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3313 PE=3 SV=1
A0A1D8PQV5_CANAL38.54%4676e-89Dihydrofolate synthetase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.6908 PE=3 SV=1
FOLD_YEAST38.44%4504e-88Dihydrofolate synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6638
Predicted cleavage: 66

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 453

Detailed signature matches

  1. Family IPR001645
    Folylpolyglutamate synthetase
    1. TIGR01499
    2. PIRSF001563 (Folylp...)
  2. Domain IPR013221
    Mur ligase, central
    1. PF08245 (Mur_ligase_M)
    2. G3DSA:3.40.11...
    3. SSF53623 (MurD-like...)
  3. Domain IPR004101
    Mur ligase, C-terminal
    1. SSF53244 (MurD-like...)
  4. SITE IPR018109
    Folylpolyglutamate synthetase, conserved site
    1. PS01012 (FOLYLPOLYG...)
    2. PS01011 (FOLYLPOLYG...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.90.19...

Protein sequence

>MCA_01869_1
MGIDLGLKRVSTLMSLLGNPHRNWYSVHVAGTNGKGSVCSYLTSVLKSAQIKSGRFTSPHLVNRWDAISIDGESVDENEF
LNVESSVRETNMRHNVGATEFELLTAVAFQIFSQRGIKVAVVEVGLGGRLDATNVLEPVQHPVGSQANGTGKGVLATIIT
KIGLDHQAFLGNSLKEIAFEKGGILKELTPCVIDATNDRDVLDTIKEISKSKNVSLKHTHVYKSGTSETPSYYIDSLRWG
KIDTSLTPLLGDYQKNNLACAISALDILSRWFPQELESKEVIIEGIKSTYWPGRLQWINTTLSLDNGEENKVRILIDGAH
NDSAADELNHFLTDHVRPKMENGKVAFVTAFTSGKNYKGIISRVVKSGDSIVATEFDSVDGMPWIKAYDSAKNAEMVSQS
VEGVSVKSCSNPITALNQVYNDAARFSRDQDPVIVVFGSLYLAGKLIAQLDKR

GO term prediction

Biological Process

GO:0009058 biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process

Molecular Function

GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity

Cellular Component

None predicted.