Protein

MIA_02416_1

Length
399 amino acids

Browser: contig03:736733-738217-

Protein function

EGGNOG:0PG3FCEG1Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate (By similarity)
SGD closest match:S000003098CEG1mRNA-capping enzyme subunit alpha

Protein alignments

%idAln lengthE-value
A0A0J9XDM9_GEOCN39.459%3701.71e-77mRNA-capping enzyme subunit alpha OS=Geotrichum candidum GN=BN980_GECA11s01550g PE=3 SV=1
UniRef50_A0A0J9XDM939.459%3703.51e-74mRNA-capping enzyme subunit alpha n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDM9_GEOCN
A0A060TC16_BLAAD39.286%3641.21e-77mRNA-capping enzyme subunit alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D32472g PE=3 SV=1
A0A1E4TG03_9ASCO40.054%3675.58e-77mRNA-capping enzyme subunit alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_108935 PE=3 SV=1
MCA_01657_138.830%3764.69e-72MCA_01657_1
A0A1D8PME6_CANAL36.667%3901.46e-71mRNA-capping enzyme subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CGT1 PE=3 SV=1
A0A1E3PE13_9ASCO37.960%3531.43e-70mRNA-capping enzyme subunit alpha OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53284 PE=3 SV=1
MCE1_YARLI34.072%3611.01e-64mRNA-capping enzyme subunit alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CEG1 PE=3 SV=1
MCE1_YEAST32.265%4372.40e-60mRNA-capping enzyme subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CEG1 PE=1 SV=2
A0A161HJT6_9ASCO42.014%2881.09e-59Ceg1p OS=Sugiyamaella lignohabitans GN=CEG1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0829

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 399

Detailed signature matches

  1. Domain IPR001339
    mRNA capping enzyme, catalytic domain
    1. PF01331 (mRNA_cap_e...)
  2. Domain IPR012310
    DNA ligase, ATP-dependent, central
    1. PS50160 (DNA_LIGASE_A3)
  3. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  4. Domain IPR013846
    mRNA capping enzyme, C-terminal
    1. PF03919 (mRNA_cap_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.47...
  3. SSF56091 (DNA ligas...)
  4. cd07895 (Adenylatio...)
  5. mobidb-lite (disord...)

Residue annotation

  1. active site cd07895
  2. CTD docking site c...

Protein sequence

>MIA_02416_1
MDYGNIFIHVSNDSISIPGKLVSESEKSYYQSRICELLNLKGYRFPGSQPVSLNRHHLSHELLDKDFYVCEKTDGVRALL
YVSPQQKSPDADVILITRANEFFKVSNITFGSHENLIDGEIVVDKEGLTKYFAFDCMAQKGKVIINQNLIERRNHLTKIY
EEYMEHKINFNMNTAPFKFYFKEMAPSYKMEAVLKHIGSKDFKHVSDGLIFTAVNAPYTIGTDKNILKWKPPHLNTVDFV
LDLEFQQVNDEKRKIKYKDYDSKPRGHLFIGLGSNNITEVGLLPFTTGEWEKLKSLQEPLVDRIVECACENKQWKFLRLR
EDKETPNHVSVYNSVLESIFDNINAQKLLAIVPSITYNWKQVRHHFDNVFQQMKPKKRAGESLEALEPRASRHKSEDRN

GO term prediction

Biological Process

GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006370 7-methylguanosine mRNA capping

Molecular Function

GO:0003910 DNA ligase (ATP) activity
GO:0004484 mRNA guanylyltransferase activity
GO:0005524 ATP binding

Cellular Component

None predicted.