Protein

MCA_01657_1

Length
478 amino acids

Gene name: CEG1

Description: mRNA-capping enzyme subunit alpha

Browser: contigA:5090113-5091908-

RNA-seq: read pairs 1035, FPKM 26.7, percentile rank 49.5% (100% = highest expression)

Protein function

Annotation:CEG1mRNA-capping enzyme subunit alpha
KEGG:K00987CEG1 mRNA guanylyltransferase [EC:2.7.7.50]
EGGNOG:0PG3FCEG1Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate (By similarity)
SGD closest match:S000003098CEG1mRNA-capping enzyme subunit alpha

Protein alignments

%idAln lengthE-value
A0A0J9XDM9_GEOCN43.73%3756e-102mRNA-capping enzyme subunit alpha OS=Geotrichum candidum GN=BN980_GECA11s01550g PE=3 SV=1
UniRef50_A0A0J9XDM943.73%3751e-98mRNA-capping enzyme subunit alpha n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XDM9_GEOCN
A0A060TC16_BLAAD41.71%3749e-90mRNA-capping enzyme subunit alpha OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D32472g PE=3 SV=1
A0A1E3PE13_9ASCO41.48%3642e-86mRNA-capping enzyme subunit alpha OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53284 PE=3 SV=1
MCE1_YARLI39.73%3651e-81mRNA-capping enzyme subunit alpha OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CEG1 PE=3 SV=1
A0A1E4TG03_9ASCO37.07%3751e-71mRNA-capping enzyme subunit alpha OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_108935 PE=3 SV=1
MCE1_YEAST36.82%4024e-69mRNA-capping enzyme subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CEG1 PE=1 SV=2
MIA_02416_138.83%3764e-68MIA_02416_1
A0A161HJT6_9ASCO40.84%3112e-67Ceg1p OS=Sugiyamaella lignohabitans GN=CEG1 PE=4 SV=1
A0A1D8PME6_CANAL35.08%3824e-65mRNA-capping enzyme subunit alpha OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CGT1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0294

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 478

Detailed signature matches

  1. Family IPR017075
    mRNA capping enzyme, alpha subunit
    1. PIRSF036959 (mRNA_c...)
  2. Domain IPR001339
    mRNA capping enzyme, catalytic domain
    1. PF01331 (mRNA_cap_e...)
  3. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  4. Domain IPR013846
    mRNA capping enzyme, C-terminal
    1. PF03919 (mRNA_cap_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.50...
  3. G3DSA:3.30.47...
  4. NON_CYTOPLASM... (N...)
  5. SSF56091 (DNA ligas...)
  6. TRANSMEMBRANE (Tran...)
  7. cd07895 (Adenylatio...)
  8. mobidb-lite (disord...)

Residue annotation

  1. active site cd07895
  2. CTD docking site c...

Protein sequence

>MCA_01657_1
MPKPPVLPDAKSRKGVFDEALLLPSSNVSIPGVLIEAMAYVVKDIIRKILEMDKYSFPGAQPVSLSKANVTNLLKEDYYV
CEKSDGMRCLLLITSHPEQKTESIFMITRKDEIYVIPKAHIPKSHHNVKPAGGAVTDFPEGTILDGELVITKNKKMKYLI
FDCLAMNGKLLLERTFDKRIAYVRELLMKPFLSYPPNSSNPNRPQIPFSLSVKTMEFAYAINKVLTDIPKLTHISDGLIF
TSTNAPYIKGTNANILKWKPPHLNTVDFVLLLKIPLSRDPEDSEDEEYEDYDKMPRFNLYIGQRNRKIELVDTMYVTEQE
WKDLKDLNEPLNGRIVECYKDENGRWRYLRFRDDKDLPNFITSYHSILNSIEDGITETQLEDMAFDIRDKWKARDSKRQE
QQRQQPPHPNVPYNNNNNNNNVNPHHHPPPPYGQMKSEPGAIKRSATQEADHEQQQQHTDPDYKTSSDHPSKRVKSEQ

GO term prediction

Biological Process

GO:0006370 7-methylguanosine mRNA capping

Molecular Function

GO:0004484 mRNA guanylyltransferase activity

Cellular Component

GO:0031533 mRNA cap methyltransferase complex