Protein

MIA_02395_1

Length
237 amino acids


Browser: contig03:683632-684789-

Protein function

EGGNOG:0PJIQATP4Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a ATP6 static relative to the rotary elements
SGD closest match:S000005999ATP4ATP synthase subunit 4, mitochondrial
CGD closest match:CAL0000200090ATP4F1F0 ATP synthase subunit 4

Protein alignments

%idAln lengthE-value
MCA_04187_178.903%2372.47e-135MCA_04187_1
A0A0J9X876_GEOCN73.840%2373.08e-122Similar to Saccharomyces cerevisiae YPL078C ATP4 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase OS=Geotrichum candidum GN=BN980_GECA05s01781g PE=4 SV=1
A0A167D550_9ASCO61.712%2227.17e-99F1F0 ATP synthase subunit 4 OS=Sugiyamaella lignohabitans GN=ATP4 PE=4 SV=1
A0A060TCW4_BLAAD55.556%2434.18e-89ARAD1D39050p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39050g PE=4 SV=1
A0A1E3PME4_9ASCO53.586%2372.32e-84Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82204 PE=4 SV=1
A0A1E4TD18_9ASCO54.630%2164.25e-80Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32808 PE=4 SV=1
Q6C105_YARLI54.854%2067.76e-79YALI0F20306p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F20306g PE=4 SV=1
Q59ZE0_CANAL52.119%2362.17e-76F1F0 ATP synthase subunit 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATP4 PE=4 SV=1
ATPF_YEAST47.934%2424.77e-74ATP synthase subunit 4, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATP4 PE=1 SV=2
UniRef50_P0562647.934%2421.14e-70ATP synthase subunit 4, mitochondrial n=83 Tax=Saccharomycetales TaxID=4892 RepID=ATPF_YEAST

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9815
Predicted cleavage: 41

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

    1. PF05405 (Mt_ATP-synt_B)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SSF161060 (ATP synt...)

Protein sequence

>MIA_02395_1
MSLRVASRSLALASRPVLARPVVGAAPIALRRLYSSEADPKAKASSILSALPGNSLVSKTGFLATLTAAGVYTISNGLYV
VNAETCIVSVFGVLLIVISKTVAPAYKEWAEGYIENVKNVLNSARDTHTLAVKERIESVSKVKDVVAITENLFKASKETV
ELEAKAFELKQQVAFAHEAKSVLDSWVRYEAQVRKKEQEALAKSVIDKVNSQVADSAFQAKVLKQAIADVEKIFSKA

GO term prediction

Biological Process

GO:0015986 ATP synthesis coupled proton transport

Molecular Function

GO:0015078 hydrogen ion transmembrane transporter activity

Cellular Component

GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)