Protein
MIA_02393_1
Length
355 amino acids
Browser: contig03:679115-680183+
Protein function
| EGGNOG: | 0PGC8 | FG01069.1 | Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) |
|---|---|---|---|
| SGD closest match: | S000001634 | YKL151C | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| CGD closest match: | CAL0000185966 | CAALFM_C602030CA | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_01793_1 | 66.96% | 339 | 2e-152 | MCA_01793_1 |
| A0A0J9X4X9_GEOCN | 56.10% | 344 | 3e-121 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Geotrichum candidum GN=BN980_GECA02s06698g PE=3 SV=1 |
| A0A060THH9_BLAAD | 51.20% | 332 | 8e-106 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38632g PE=3 SV=1 |
| A0A1E3PMI0_9ASCO | 48.10% | 343 | 2e-96 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45965 PE=3 SV=1 |
| UniRef50_A0A1D2VFK3 | 43.99% | 366 | 8e-82 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A1D2VFK3_9ASCO |
| A0A167E876_9ASCO | 53.08% | 292 | 6e-84 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Sugiyamaella lignohabitans GN=AWJ20_4706 PE=3 SV=1 |
| Q6C9G9_YARLI | 48.62% | 290 | 6e-78 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D11308g PE=3 SV=1 |
| NNRD_CANAL | 36.41% | 368 | 3e-73 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C602030CA PE=3 SV=2 |
| A0A1E4TGT8_9ASCO | 43.90% | 328 | 3e-71 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2704 PE=3 SV=1 |
| NNRD_YEAST | 40.79% | 353 | 9e-66 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YKL151C PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.5535
Predicted cleavage: 38
Protein family membership
- ATP-dependent (S)-NAD(P)H-hydrate dehydratase (IPR000631)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
355
Detailed signature matches
Residue annotation
-
putative substrate...
-
putative ATP bindi...
Protein sequence
>MIA_02393_1 MSQSLLHRLSPAQILGLARNLVPPLSDAFYKGQAGRIVVVGGCEDYTGAPYFSALASTLLGADMSHIICERNAATAIKSY SPNLMVHPYLFDSASQKQYAAYGVPTDQDAVIQKVLAVLDRVHVVVVGPGLGRDKLLLQTTARIIQEAIKRSKPIVIDAD GLFLVQQNPDLIRGYQNAILTPNVIELQRLRDSVGLPPYVAKDNVEHILELQKLSKLYGDITILEKGKSDYISNATTTVE NPTIGGLKRVSGQGDTLSGTVSTFLAWKVAFESEGLWPHKQHLTITQQGVPVPLTSKDLFLVAAFGASTVTRLSSHKAFK AHGRALVTSQISDFIGESFHELFETGDKPNPNVSL
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity
Cellular Component
None predicted.