Protein
MCA_01793_1
Length
357 amino acids
Browser: contigA:5474734-5475808-
RNA-seq: read pairs 2935, FPKM 101.3, percentile rank 78.9% (100% = highest expression)
Protein function
KEGG: | K17757 | CARKD | ATP-dependent NAD(P)H-hydrate dehydratase [EC:4.2.1.93] |
---|---|---|---|
EGGNOG: | 0PGC8 | FG01069.1 | Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) |
SGD closest match: | S000001634 | YKL151C | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
CGD closest match: | CAL0000185966 | CAALFM_C602030CA | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_02393_1 | 66.96% | 339 | 5e-164 | MIA_02393_1 |
A0A0J9X4X9_GEOCN | 60.06% | 333 | 3e-139 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Geotrichum candidum GN=BN980_GECA02s06698g PE=3 SV=1 |
A0A060THH9_BLAAD | 54.01% | 324 | 1e-127 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38632g PE=3 SV=1 |
A0A1E3PMI0_9ASCO | 46.71% | 334 | 8e-108 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45965 PE=3 SV=1 |
UniRef50_Q7SHU9 | 45.45% | 341 | 3e-101 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase n=182 Tax=Fungi TaxID=4751 RepID=NNRD_NEUCR |
A0A167E876_9ASCO | 55.02% | 289 | 7e-102 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Sugiyamaella lignohabitans GN=AWJ20_4706 PE=3 SV=1 |
Q6C9G9_YARLI | 49.11% | 281 | 8e-97 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D11308g PE=3 SV=1 |
NNRD_CANAL | 40.32% | 372 | 7e-91 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C602030CA PE=3 SV=2 |
A0A1E4TGT8_9ASCO | 46.25% | 320 | 6e-90 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2704 PE=3 SV=1 |
NNRD_YEAST | 44.51% | 346 | 7e-88 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YKL151C PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.5283
Predicted cleavage: 35
Protein family membership
- ATP-dependent (S)-NAD(P)H-hydrate dehydratase (IPR000631)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
357
Detailed signature matches
Residue annotation
-
putative substrate...
-
putative ATP bindi...
Protein sequence
>MCA_01793_1 MSLSTITHKSALSLIRNFIPPLSNAFHKGQAGRVAVVGGCEDYTGAPYFSALASTLLGADMSHVICEKSAATALKSYSPN LMVHPYLFDSTSEKQYASYGVPTDEEAVMSKVLAVIDRVHVVVVGPGLGRDAVLLKTIKRIIEEVKKRSMPLVIDADGLY LVQQHPEVIKGYNKVILTPNVVEFQRLKDSIGFKPKESSTHEENLQKLCELLGGVSILEKGKSDYISNESTTLENPLPGG LKRVSGQGDTLTGTLATFLAWQKAFQTPDVWDHPKSIEFEGQKLTERDLYLLAAFGASAVTRYASYLAFKNHGRALLTSQ ISDYIGQSYRTLFESDIDSNPELKNYFDGDANQLSKV
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity
Cellular Component
None predicted.