Protein

MCA_01793_1

Length
357 amino acids

Browser: contigA:5474734-5475808-

RNA-seq: read pairs 2935, FPKM 101.3, percentile rank 78.9% (100% = highest expression)

Protein function

KEGG:K17757CARKD ATP-dependent NAD(P)H-hydrate dehydratase [EC:4.2.1.93]
EGGNOG:0PGC8FG01069.1Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
SGD closest match:S000001634YKL151CATP-dependent (S)-NAD(P)H-hydrate dehydratase
CGD closest match:CAL0000185966CAALFM_C602030CAATP-dependent (S)-NAD(P)H-hydrate dehydratase

Protein alignments

%idAln lengthE-value
MIA_02393_166.96%3395e-164MIA_02393_1
A0A0J9X4X9_GEOCN60.06%3333e-139ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Geotrichum candidum GN=BN980_GECA02s06698g PE=3 SV=1
A0A060THH9_BLAAD54.01%3241e-127ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D38632g PE=3 SV=1
A0A1E3PMI0_9ASCO46.71%3348e-108ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45965 PE=3 SV=1
UniRef50_Q7SHU945.45%3413e-101ATP-dependent (S)-NAD(P)H-hydrate dehydratase n=182 Tax=Fungi TaxID=4751 RepID=NNRD_NEUCR
A0A167E876_9ASCO55.02%2897e-102ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Sugiyamaella lignohabitans GN=AWJ20_4706 PE=3 SV=1
Q6C9G9_YARLI49.11%2818e-97ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D11308g PE=3 SV=1
NNRD_CANAL40.32%3727e-91ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C602030CA PE=3 SV=2
A0A1E4TGT8_9ASCO46.25%3206e-90ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2704 PE=3 SV=1
NNRD_YEAST44.51%3467e-88ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YKL151C PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5283
Predicted cleavage: 35

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 357

Detailed signature matches

  1. Family IPR000631
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    1. PS51383 (YJEF_C_3)
    2. PF01256 (Carb_kinase)
    3. TIGR00196
    4. cd01171 (YXKO-related)
    5. MF_01965 (NADHX_deh...)
  2. Domain IPR029056
    Ribokinase-like
    1. G3DSA:3.40.11...
    2. SSF53613 (Ribokinas...)
  3. SITE IPR017953
    Carbohydrate kinase, predicted, conserved site
    1. PS01049 (YJEF_C_1)

Residue annotation

  1. putative substrate...
  2. putative ATP bindi...

Protein sequence

>MCA_01793_1
MSLSTITHKSALSLIRNFIPPLSNAFHKGQAGRVAVVGGCEDYTGAPYFSALASTLLGADMSHVICEKSAATALKSYSPN
LMVHPYLFDSTSEKQYASYGVPTDEEAVMSKVLAVIDRVHVVVVGPGLGRDAVLLKTIKRIIEEVKKRSMPLVIDADGLY
LVQQHPEVIKGYNKVILTPNVVEFQRLKDSIGFKPKESSTHEENLQKLCELLGGVSILEKGKSDYISNESTTLENPLPGG
LKRVSGQGDTLTGTLATFLAWQKAFQTPDVWDHPKSIEFEGQKLTERDLYLLAAFGASAVTRYASYLAFKNHGRALLTSQ
ISDYIGQSYRTLFESDIDSNPELKNYFDGDANQLSKV

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity

Cellular Component

None predicted.