Protein
MIA_02343_1
Length
718 amino acids
Browser: contig03:518686-520843+
Protein function
| EGGNOG: | 0PH40 | HDA3 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events |
|---|---|---|---|
| SGD closest match: | S000006383 | HDA3 | HDA1 complex subunit 3 |
| CGD closest match: | CAL0000189420 | CAALFM_CR09490WA | Uncharacterized protein |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_04161_1 | 56.522% | 690 | 0.0 | MCA_04161_1 |
| A0A0J9X3F1_GEOCN | 41.507% | 730 | 5.49e-174 | Similar to Saccharomyces cerevisiae YPR179C HDA3 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex OS=Geotrichum candidum GN=BN980_GECA02s03838g PE=4 SV=1 |
| UniRef50_A0A0J9X3F1 | 41.507% | 730 | 1.12e-170 | Similar to Saccharomyces cerevisiae YPR179C HDA3 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3F1_GEOCN |
| A0A167CYV7_9ASCO | 44.776% | 402 | 3.76e-96 | Hda3p OS=Sugiyamaella lignohabitans GN=HDA3 PE=4 SV=1 |
| A0A060T8D5_BLAAD | 45.588% | 340 | 4.77e-88 | ARAD1C36058p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C36058g PE=4 SV=1 |
| Q6C4B7_YARLI | 44.214% | 337 | 2.08e-87 | YALI0E28204p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E28204g PE=4 SV=1 |
| HDA3_YEAST | 40.469% | 341 | 4.67e-73 | HDA1 complex subunit 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HDA3 PE=1 SV=1 |
| A0A1D8PTZ2_CANAL | 44.974% | 189 | 5.62e-36 | Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR09490WA PE=4 SV=1 |
| A0A1E4TEH1_9ASCO | 26.349% | 315 | 5.77e-25 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31164 PE=4 SV=1 |
| A0A1E3PJI9_9ASCO | 30.921% | 304 | 5.86e-17 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50790 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0167
Protein family membership
- HDA1 complex subunit 2/3 (IPR021006)
- HDA1 complex subunit 3 (IPR026216)
Domains and repeats
-
Domain
1
100
200
300
400
500
600
718
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MIA_02343_1 MDLGRILDGTPEPPAIVPSLEFFSGGKRAPADKNSALDYVLPVPMTPFQKQLTDDVVSLHYSDILRFFECGSLDNQVLHD SLASLYANTQLVATHPYLLVQHYLPPNLLLKDVPNRLTNSSGKFAVLVKLIDMLRDKKVDVALVSRAGKSFDLIEALLLG RAVNYRRYSGSYLRQSTKSFKKASTIHLFPSSHLASTYIGSERFHLIIAFDLTFNPEDAHITAIRTQSRGANDPPAPIIR LIPYYSAEHIVYKFQNIKLDDETLYMKRVVAAIVVLRGRAGSVPVDLRPHYASGLKFLAPWLEDPVAHSWTLPKTPDIEI YSAQDVEKSLLTEVNVDAKHPIDPESSTNFYSTSISSNQHDSNSNNQANGHSHHSSNSSSSTSQPYNYSLANGVPKQFTK SGRDLSHSNIHRYHPADENENDEYYNAKRRKRERYSPGAPETATSFLAPPGGGLYQQQSDRQILTHKILRRLDNATRDLA LRQAEVTSLRSQASVRQSMYEDLSTEAGKLVTEISTLKEQLQVQERKSERSDAEVEKLTNKLGQQTKDLEEAREMLANGP PDLATLEKQRARIAELEDLVKKADERADLRTTENDYMRSEYQKASTAATDALEEVKTLKAAKNALEVRLESRAIELQQLT FDEERKTKDERIAELETKTGNLEEHLKRLQEAERHQPTRSRYGMRNSSANSRRNNSPSVSGGSGGNSGNGRRGSPAIS
GO term prediction
Biological Process
GO:0016575 histone deacetylation
Molecular Function
None predicted.
Cellular Component
GO:0005634 nucleus
GO:0070823 HDA1 complex