Protein

MIA_02335_1

Length
506 amino acids

Browser: contig03:505678-507285+

Protein function

EGGNOG:0PGQ4LAT1Pyruvate dehydrogenase
SGD closest match:S000005015LAT1Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
CGD closest match:CAL0000189879LAT1Acetyltransferase component of pyruvate dehydrogenase complex

Protein alignments

%idAln lengthE-value
A0A060T9T6_BLAAD65.688%4435.56e-175Acetyltransferase component of pyruvate dehydrogenase complex OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21516g PE=3 SV=1
MCA_03928_179.870%3088.33e-168MCA_03928_1
UniRef50_G8YQ1756.559%4652.02e-163Acetyltransferase component of pyruvate dehydrogenase complex n=6 Tax=cellular organisms TaxID=131567 RepID=G8YQ17_PICSO
A0A0J9X447_GEOCN78.827%3079.93e-152Acetyltransferase component of pyruvate dehydrogenase complex OS=Geotrichum candidum GN=BN980_GECA02s03772g PE=3 SV=1
A0A170QYX9_9ASCO70.130%3089.14e-142Acetyltransferase component of pyruvate dehydrogenase complex OS=Sugiyamaella lignohabitans GN=LAT1 PE=3 SV=1
Q6C812_YARLI69.055%3072.18e-138Acetyltransferase component of pyruvate dehydrogenase complex OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23683g PE=3 SV=1
A0A1E4TAS1_9ASCO67.857%3087.01e-133Acetyltransferase component of pyruvate dehydrogenase complex OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32304 PE=3 SV=1
A0A1E3PQC4_9ASCO62.215%3074.62e-129Acetyltransferase component of pyruvate dehydrogenase complex OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45323 PE=3 SV=1
Q5AGX8_CANAL61.364%3082.23e-120Acetyltransferase component of pyruvate dehydrogenase complex OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LAT1 PE=3 SV=1
ODP2_YEAST57.556%3112.71e-109Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAT1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9761
Predicted cleavage: 52

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 506

Detailed signature matches

  1. Family IPR006257
    Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    1. TIGR01349
  2. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  3. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  4. Domain IPR004167
    E3-binding domain
    1. SSF47005 (Periphera...)
    2. G3DSA:4.10.32...
    3. PF02817 (E3_binding)
  5. Domain IPR001078
    2-oxoacid dehydrogenase acyltransferase, catalytic domain
    1. PF00198 (2-oxoacid_dh)
  6. SITE IPR003016
    2-oxo acid dehydrogenase, lipoyl-binding site
    1. PS00189 (LIPOYL)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.55...
  2. G3DSA:3.90.11...
  3. SSF52777 (CoA-depen...)
  4. cd06849 (lipoyl_domain)
  5. mobidb-lite (disord...)

Residue annotation

  1. E3 interaction sur...
  2. lipoyl attachment ...

Protein sequence

>MIA_02335_1
MATALLYAPRAAFSRPAIRLASATSRLVPTQPLASSFQHHHQMLLLAARTYASKSFPPHTIIDMPALSPTMTVGNVGAWQ
KAIGDKLAPGDILVEIETDKAQMDFEFQEDGYLAKILIEQGAKDVPVGTPIGVYVEDAADVPAFADFTAADAGPAPAASS
AAAPAAAPEEASAALEPAKSAEPAAPAAAAATPSTTSSDRIKASPLAKMIALEKGIPLKDIKGTGPDGRIIKRDVENWVP
KAAPAAPAAASTAAAPSAATPAAAAPVVTSTSPYEDIPISQMRKTIASRLQQSKVTAPHYTVSSTISVSKLLKIRAALNA
AAEPGEFKLSVNDLLIKAIGVANLKVPTVNTSWLDAQGVLRQYKNVDVSVAVATPSGLITPVVKAVNLKGLAEISNEIKA
LGKRAREGKLLPEEYQGGTVTISNMGMNPAVSNFTAIINPPQSAILAVGTTERRAIEDPEAESGISFDSVMTVTASFDHR
VVDGAVGAEWIKALKKVIENPIELML

GO term prediction

Biological Process

GO:0006090 pyruvate metabolic process
GO:0008152 metabolic process

Molecular Function

GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
GO:0016746 transferase activity, transferring acyl groups

Cellular Component

GO:0045254 pyruvate dehydrogenase complex