MCA_03928_1
Gene name: LAT1
Description: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Browser: contigC:1516424-1518317-
RNA-seq: read pairs 20411, FPKM 491.6, percentile rank 94.1% (100% = highest expression)
Protein function
| Annotation: | LAT1 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | |
|---|---|---|---|
| KEGG: | K00627 | DLAT | pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12] |
| EGGNOG: | 0PGQ4 | LAT1 | Pyruvate dehydrogenase |
| SGD closest match: | S000005015 | LAT1 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| CGD closest match: | CAL0000189879 | LAT1 | Acetyltransferase component of pyruvate dehydrogenase complex |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02335_1 | 79.87% | 308 | 3e-155 | MIA_02335_1 |
| A0A0J9X447_GEOCN | 76.55% | 307 | 5e-141 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Geotrichum candidum GN=BN980_GECA02s03772g PE=3 SV=1 |
| A0A170QYX9_9ASCO | 72.40% | 308 | 8e-136 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Sugiyamaella lignohabitans GN=LAT1 PE=3 SV=1 |
| A0A060T9T6_BLAAD | 73.38% | 308 | 3e-130 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21516g PE=3 SV=1 |
| Q6C812_YARLI | 72.31% | 307 | 4e-130 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23683g PE=3 SV=1 |
| A0A1E4TAS1_9ASCO | 68.93% | 309 | 4e-127 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32304 PE=3 SV=1 |
| A0A1E3PQC4_9ASCO | 65.58% | 308 | 1e-120 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45323 PE=3 SV=1 |
| UniRef50_G8YQ17 | 60.06% | 308 | 6e-108 | Acetyltransferase component of pyruvate dehydrogenase complex n=6 Tax=cellular organisms TaxID=131567 RepID=G8YQ17_PICSO |
| Q5AGX8_CANAL | 62.34% | 308 | 2e-109 | Acetyltransferase component of pyruvate dehydrogenase complex OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LAT1 PE=3 SV=1 |
| ODP2_YEAST | 58.20% | 311 | 1e-100 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAT1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9794
Predicted cleavage: 48
Protein family membership
Domains and repeats
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Domain
Detailed signature matches
no IPR
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SSF52777 (CoA-depen...)
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cd06849 (lipoyl_domain)
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mobidb-lite (disord...)
Residue annotation
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E3 interaction sur...
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lipoyl attachment ...
Protein sequence
>MCA_03928_1 MSVLISCSKSHFARATWRTVAPSTFKATSSLFVQRPQQSQLLLSRLYASKSFPPHTVIDMPALSPTMTVGNVGAWQKAVG DKLTPGDVLVEIETDKAQMDFEFQDEGYLAKILVEQGAKDVAVGTPIGVYVEDADDVAAFADFTAADAGSAAPAAAPASS ESKKSEPSSSEPAESKKESSEPSSSEKQSSSSSSSSSSESSEPSDRIKASPIAKMIALEKGIPLKDIKGSGPGGRIIKRD VEDWKPPAAAPAKEAPAKQASAATPSATPGPAPEIPGAAYEDIPISMMRKTIASRLQLSKNTAPHYTVSSTVSVSKLLKL RAALNAGAQNGEYKLSVNDMLVKAMAIANLKVPTVNTSWLEQEGVLRQYKNVDVSVAVATPTGLITPVVRNVNLKGLAAI SNEIKALGKRAREGKLLPEEYQGGTITISNMGMNPAVSHFTAIINPPQSAILAIGTTERRAVEDPESENGISFDNVMTVT ASFDHRVVDGAVGAEWIKALKKVIENPIEFML
GO term prediction
Biological Process
GO:0006090 pyruvate metabolic process
GO:0008152 metabolic process
Molecular Function
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Cellular Component
GO:0045254 pyruvate dehydrogenase complex