MIA_02321_1

Protein

Length

772 amino acids

Protein function

EGGNOG:	0PIX8	PGUG_03702	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
SGD closest match:	S000006034	YPL113C	Putative 2-hydroxyacid dehydrogenase YPL113C
CGD closest match:	CAL0000175261	orf19.1796	Glyoxylate reductase

Protein alignments

	%id	Aln length	E-value
MCA_04149_1	56.34%	410	9e-158	MCA_04149_1
A0A0J9XI09_GEOCN	51.20%	375	4e-134	Similar to Saccharomyces cerevisiae YPL113C Glyoxylate reductase, acts on glyoxylate and hydroxypyruvate substrates OS=Geotrichum candidum GN=BN980_GECA17s02342g PE=3 SV=1
UniRef50_A0A0J9XI09	51.20%	375	8e-131	Similar to Saccharomyces cerevisiae YPL113C Glyoxylate reductase, acts on glyoxylate and hydroxypyruvate substrates n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XI09_GEOCN
A0A060TDI1_BLAAD	44.23%	364	2e-96	ARAD1D00484p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00484g PE=3 SV=1
A0A1E3PQQ9_9ASCO	44.96%	387	7e-94	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80943 PE=3 SV=1
A0A167CQI0_9ASCO	39.21%	380	4e-88	Glyoxylate reductase OS=Sugiyamaella lignohabitans GN=AWJ20_213 PE=3 SV=1
Q59P08_CANAL	39.94%	353	2e-72	Glyoxylate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1796 PE=3 SV=1
Q6C5A6_YARLI	37.57%	378	1e-65	YALI0E19657p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E19657g PE=3 SV=1
YP113_YEAST	31.09%	386	2e-50	Putative 2-hydroxyacid dehydrogenase YPL113C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPL113C PE=2 SV=1
A0A1E4TAG1_9ASCO	27.70%	379	2e-34	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28277 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7422
Predicted cleavage: 13

Protein family membership

None predicted.

Domains and repeats

Domain
58 - 383
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
393 - 764
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (IPR006139)
Domain
210 - 360
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)
583 - 733
NAD(P)-binding domain (IPR016040)
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain (IPR006140)

1 100 200 300 400 500 600 700 772

Detailed signature matches

IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
1. PF00389 (2-Hacid_dh)
  
  393 - 764
  
  Pfam
  PF00389 (2-Hacid_dh)
  
  58 - 383
  
  Pfam
  PF00389 (2-Hacid_dh)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  210 - 360
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  583 - 733
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
1. PF02826 (2-Hacid_dh_C)
  
  583 - 732
  
  Pfam
  PF02826 (2-Hacid_dh_C)
  
  210 - 359
  
  Pfam
  PF02826 (2-Hacid_dh_C)
IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
1. PS00671 (D_2_HYDROX...)
  
  299 - 315
  
  PROSITE patterns
  PS00671 (D_2_HYDROXYACID_DH_3)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

5 - 139

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

140 - 362

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

390 - 512

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

513 - 733

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
SSF52283 (Formate/g...)

391 - 508

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)

16 - 133

SUPERFAMILY
SSF52283 (Formate/glycerate dehydrogenase catalytic domain-like)
cd12168 (Mand_dh_like)

391 - 759

CDD
cd12168 (Mand_dh_like)

17 - 381

CDD
cd12168 (Mand_dh_like)

Residue annotation

putative ligand bi...

71Y

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)

99A

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)

100V

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)

101G

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)

124A

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)

310R

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)

357H

putative ligand binding site
71Y, 99A, 100V, 101G, 124A, 310R, 357H
CDD
cd12168 (Mand_dh_like)
dimerization inter...

126S

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

127P

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

130D

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

134Y

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

137L

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

138G

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

141R

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

143S

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

144P

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

153V

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

169W

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

173T

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

174G

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

177V

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

180R

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

181D

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

182P

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

214R

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

216H

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

232F

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

233K

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

236S

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

237V

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

336F

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

339E

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

340P

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

341S

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

347C

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

349R

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

352V

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

353I

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

354L

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

355T

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

356P

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

357H

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

358I

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

359G

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

362T

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

363H

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

364E

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)

366V

dimerization interface
126S, 127P, 130D, 134Y, 137L, 138G, 141R, 143S, 144P, 153V, 169W, 173T, 174G, 177V, 180R, 181D, 182P, 214R, 216H, 232F, 233K, 236S, 237V, 336F, 339E, 340P, 341S, 347C, 349R, 352V, 353I, 354L, 355T, 356P, 357H, 358I, 359G, 362T, 363H, 364E, 366V
CDD
cd12168 (Mand_dh_like)
NAD binding site c...

128V

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

223F

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

224G

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

225A

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

226I

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

245K

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

246R

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

280A

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

281L

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

282P

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

283M

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

284C

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

287T

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

308I

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

309G

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

310R

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

334D

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

357H

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

359G

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)

360S

NAD binding site
128V, 223F, 224G, 225A, 226I, 245K, 246R, 280A, 281L, 282P, 283M, 284C, 287T, 308I, 309G, 310R, 334D, 357H, 359G, 360S
CDD
cd12168 (Mand_dh_like)
catalytic site cd1...

310R

catalytic site
310R, 339E, 357H
CDD
cd12168 (Mand_dh_like)

339E

catalytic site
310R, 339E, 357H
CDD
cd12168 (Mand_dh_like)

357H

catalytic site
310R, 339E, 357H
CDD
cd12168 (Mand_dh_like)
putative ligand bi...

444Y

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)

472A

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)

473V

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)

474G

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)

497A

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)

683R

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)

730H

putative ligand binding site
444Y, 472A, 473V, 474G, 497A, 683R, 730H
CDD
cd12168 (Mand_dh_like)
dimerization inter...

499N

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

500P

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

503D

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

507Y

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

510L

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

511G

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

514H

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

516S

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

517P

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

530G

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

532C

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

535I

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

536L

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

539G

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

542W

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

543N

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

586P

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

587R

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

589H

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

605L

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

606R

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

609S

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

610I

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

709F

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

712E

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

713P

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

714I

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

720C

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

722R

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

725V

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

726I

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

727L

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

728T

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

729P

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

730H

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

731T

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

732G

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

735T

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

736Q

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

737E

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)

739V

dimerization interface
499N, 500P, 503D, 507Y, 510L, 511G, 514H, 516S, 517P, 530G, 532C, 535I, 536L, 539G, 542W, 543N, 586P, 587R, 589H, 605L, 606R, 609S, 610I, 709F, 712E, 713P, 714I, 720C, 722R, 725V, 726I, 727L, 728T, 729P, 730H, 731T, 732G, 735T, 736Q, 737E, 739V
CDD
cd12168 (Mand_dh_like)
NAD binding site c...

501V

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

596L

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

597G

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

598A

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

599I

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

618N

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

619R

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

653S

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

654L

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

655P

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

656I

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

657N

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

660T

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

681I

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

682G

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

683R

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

707D

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

730H

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

732G

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)

733S

NAD binding site
501V, 596L, 597G, 598A, 599I, 618N, 619R, 653S, 654L, 655P, 656I, 657N, 660T, 681I, 682G, 683R, 707D, 730H, 732G, 733S
CDD
cd12168 (Mand_dh_like)
catalytic site cd1...

683R

catalytic site
683R, 712E, 730H
CDD
cd12168 (Mand_dh_like)

712E

catalytic site
683R, 712E, 730H
CDD
cd12168 (Mand_dh_like)

730H

catalytic site
683R, 712E, 730H
CDD
cd12168 (Mand_dh_like)

Protein sequence

>MIA_02321_1
MTRSIGKVICNDKPVSKPKVLIIGDVNTDNEDFESFSMNFNYTFYGLTTKKNFIKDIQTIHNDVHAIWCMYYGFLPIGGL
TKDIVQYLPSSLKIIVTSAVGFDPFDISALGSRGIIVCNSPGLAASPVSDHALYLTLGLYRYSPVFEHILRKVKNTGDCR
ALLQSGIPWNNDTGRPVLCRDPAQACDSDNTDVPTKPVFGFGEKVGNRYVRQPRGHKVGIAGFGAIGKEIGFKLHSVGME
VHYTKRTPLSPQEIKNLGYPVTYQKSFEDLLPESDLLVLALPMCSATKHIVNDRTLKMLPEGARIVNIGRGGLIDTSALL
QALKSGRLAGAALDVFEDEPSIDDDLCSRWDVILTPHIGSSTHENVLGAEKICMGNIFNLFYGNGNALSIPKVLIFGEVN
THTDDFKRFAKSFDYEFYNLTTKEKFIQDIQTIYKDVDAFWCMYFGFIPIGGLTNDLVKYLPPNLKIIVTSAVGYDPFDV
VALGARGISVCNSPGLAANPVADHVLYVTLGLYHYSPVFENLLRQTKNTGDCRAILQSGLPWNNEIGRPVFCRLPSDTVT
DDRADIPVKPVYGFGDKVGDRFVRQPRGHVVGIAGLGAIGKEIGLRLSSIGMKVCYHNRTKLNPDQEANLGYTATYYKSF
EDMLPNIDLLVLSLPINDSTKHIVNEKTLALLPQGAKIVNIGRGGLIDTKALIHHLKTGKIHGAALDVFEKEPIVEEELC
DRWDVILTPHTGSSTQENVLGAEKICIDNLLDIFYKEGKLLTIVNKNHLSVK

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component