Protein

MCA_04149_1

Length
433 amino acids

Description: putative 2-hydroxyacid dehydrogenase

Browser: contigC:2196705-2198007+

RNA-seq: read pairs 3311, FPKM 94.3, percentile rank 77.6% (100% = highest expression)

Protein function

Annotation:putative 2-hydroxyacid dehydrogenase
EGGNOG:0PIX8PGUG_03702oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
SGD closest match:S000006034YPL113CPutative 2-hydroxyacid dehydrogenase YPL113C
CGD closest match:CAL0000175261orf19.1796Glyoxylate reductase

Protein alignments

%idAln lengthE-value
MIA_02321_156.34%4105e-158MIA_02321_1
A0A0J9XD49_GEOCN51.23%4086e-139Similar to Saccharomyces cerevisiae YPL113C Glyoxylate reductase, acts on glyoxylate and hydroxypyruvate substrates OS=Geotrichum candidum GN=BN980_GECA08s04190g PE=3 SV=1
UniRef50_A0A0J9XD4951.23%4081e-135Similar to Saccharomyces cerevisiae YPL113C Glyoxylate reductase, acts on glyoxylate and hydroxypyruvate substrates n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XD49_GEOCN
A0A060TDI1_BLAAD39.49%3952e-91ARAD1D00484p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00484g PE=3 SV=1
A0A167CQI0_9ASCO36.97%4222e-84Glyoxylate reductase OS=Sugiyamaella lignohabitans GN=AWJ20_213 PE=3 SV=1
A0A1E3PQQ9_9ASCO37.41%4173e-80Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_80943 PE=3 SV=1
Q59P08_CANAL35.77%3979e-70Glyoxylate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.1796 PE=3 SV=1
Q6C5A6_YARLI31.64%4141e-57YALI0E19657p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E19657g PE=3 SV=1
YP113_YEAST28.71%4183e-50Putative 2-hydroxyacid dehydrogenase YPL113C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPL113C PE=2 SV=1
A0A1E4TAG1_9ASCO37.32%1426e-23Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28277 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0411
Predicted cleavage: 13

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 433

Detailed signature matches

  1. Domain IPR006139
    D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
    1. PF00389 (2-Hacid_dh)
  2. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  3. Domain IPR006140
    D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
    1. PF02826 (2-Hacid_dh_C)
  4. SITE IPR029753
    D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
    1. PS00671 (D_2_HYDROX...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. SSF52283 (Formate/g...)
  3. mobidb-lite (disord...)

Protein sequence

>MCA_04149_1
MTISKQTLGKRPKVLLIGDINTHTLDFAKFAEECDFAFYEMSTREDFEHVISTVYTDIDAIWCMYHGFGPIGGLPASLVK
KLPSTLKLLVLSAVGYDIYDVKALAARGVVVCNSPGLAAAPVADHVLYLTLALFRFSPVFEHVLRKVKNSNDCRTALDTG
FKWDLELGRPKQYYGPVKSKQMEPAKSDDDDKDDEENIQKRASTPQRADDEELASTADSGRVVYSFGDRIGDRWVRQPRT
HSVGIAGFGAIGKEIGARLASIGMKVHYTKRTPLTPEEEAGLGYEARYHESLVQMLPFSDVLVLALPLNEDTKHIMNDKT
FPLLPPDARVINIGRGPLIDTQALLRALKSGKLWGAALDVFEHEPIVEPELCSRWDVILTPHTASSTYENVLAAEKICMN
NIHELFYGDPSKMTIVNKQYLDEYKQQAQQAQE

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

Cellular Component

None predicted.