Protein

MIA_02314_1

Length
399 amino acids

Browser: contig03:449197-450528+

Protein function

EGGNOG:0PGU1FG01348.1or apyrimidinic site) lyase
SGD closest match:S000001597APN1DNA-(apurinic or apyrimidinic site) lyase 1
CGD closest match:CAL0000192941APN1DNA-(Apurinic or apyrimidinic site) lyase

Protein alignments

%idAln lengthE-value
MCA_04217_174.534%3220.0MCA_04217_1
A0A0J9X4R5_GEOCN64.329%3284.54e-158Similar to Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease OS=Geotrichum candidum GN=BN980_GECA02s05708g PE=3 SV=1
A0A060T4Q3_BLAAD63.253%3321.39e-151ARAD1A19514p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A19514g PE=3 SV=1
A0A1E3PT63_9ASCO56.977%3449.85e-139Major apurinic/apyrimidinic endonuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49158 PE=3 SV=1
Q6CC63_YARLI58.696%3221.46e-133YALI0C12144p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12144g PE=3 SV=1
UniRef50_Q6CC6358.696%3223.39e-130YALI0C12144p n=3 Tax=Saccharomycetales TaxID=4892 RepID=Q6CC63_YARLI
APN1_YEAST53.636%3301.60e-127DNA-(apurinic or apyrimidinic site) lyase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APN1 PE=1 SV=4
A0A1D8PKJ7_CANAL51.393%3234.37e-124DNA-(Apurinic or apyrimidinic site) lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=APN1 PE=3 SV=1
A0A1E4TBF1_9ASCO47.619%3155.14e-94Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133455 PE=3 SV=1
A0A167C4G9_9ASCO60.870%2071.25e-85DNA-(Apurinic or apyrimidinic site) lyase APN1 OS=Sugiyamaella lignohabitans GN=APN1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9797
Predicted cleavage: 67

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 399

Detailed signature matches

  1. Family IPR001719
    AP endonuclease 2
    1. TIGR00587
    2. cd00019 (AP2Ec)
    3. MF_00152 (Nfo)
    4. PS51432 (AP_NUCLEAS...)
    5. SM00518 (ap2real3)
  2. Domain IPR013022
    Xylose isomerase-like, TIM barrel domain
    1. SSF51658 (Xylose is...)
    2. PF01261 (AP_endonuc_2)
  3. SITE IPR018246
    AP endonuclease 2, zinc binding site
    1. PS00730 (AP_NUCLEAS...)
    2. PS00729 (AP_NUCLEAS...)
    3. PS00731 (AP_NUCLEAS...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.20.20...
  3. mobidb-lite (disord...)

Residue annotation

  1. AP (apurinic/apyri...
  2. DNA interaction c...
  3. Metal-binding acti...

Protein sequence

>MIA_02314_1
MPARKAATTVSKKGSGSVNQFSRTPGLKYYVGAHISTAGGVENCVPNALKLGCNAFAFFPKNQRRWSSAQYKKENIDGFH
SCCSHEHFNAKKEVLPHGSYLINLGNPDAAKRKQSQESFEDDLKRCEQLGVGLYNLHPGSAVGGADKNATIKHIASGINK
GIAATKFIKVVLENMAGHGHIIGSDLQDLADIIELVQDKSRIGVCIDTCHTFAAGYDIRDQKTFNEFWDKFNKTVGYQYL
AGLHLNDSKAPLGSKRDLHQNIGLGFLGLETFRLIMNKEELQGLPMILETPIPNEEKVNKGLEADIRGDEIKLLEWLIGK
ESDDEFIEKSKELQKKGEKERKEHQEKFDKKKEKDEAALSKKRKNTVDLDFFAPKKRASTRKTKKEESDVKEEEEDGSE

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.