Protein

MCA_04217_1

Length
382 amino acids

Gene name: APN1

Description: DNA-(apurinic or apyrimidinic site) lyase 1

Browser: contigC:2380127-2381438-

RNA-seq: read pairs 848, FPKM 27.4, percentile rank 50.1% (100% = highest expression)

Protein function

Annotation:APN1DNA-(apurinic or apyrimidinic site) lyase 1
KEGG:K10771APEX1 AP endonuclease 1 [EC:4.2.99.18]
EGGNOG:0PGU1FG01348.1or apyrimidinic site) lyase
SGD closest match:S000001597APN1DNA-(apurinic or apyrimidinic site) lyase 1
CGD closest match:CAL0000192941APN1DNA-(Apurinic or apyrimidinic site) lyase

Protein alignments

%idAln lengthE-value
MIA_02314_169.48%3670.0MIA_02314_1
A0A0J9X4R5_GEOCN67.69%3252e-165Similar to Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease OS=Geotrichum candidum GN=BN980_GECA02s05708g PE=3 SV=1
A0A060T4Q3_BLAAD61.75%3323e-149ARAD1A19514p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A19514g PE=3 SV=1
A0A1E3PT63_9ASCO60.98%3287e-149Major apurinic/apyrimidinic endonuclease OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49158 PE=3 SV=1
A0A1D8PKJ7_CANAL53.85%3252e-128DNA-(Apurinic or apyrimidinic site) lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=APN1 PE=3 SV=1
Q6CC63_YARLI55.21%3262e-126YALI0C12144p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12144g PE=3 SV=1
UniRef50_Q6CC6355.21%3265e-123YALI0C12144p n=3 Tax=Saccharomycetales TaxID=4892 RepID=Q6CC63_YARLI
APN1_YEAST51.52%3301e-122DNA-(apurinic or apyrimidinic site) lyase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APN1 PE=1 SV=4
A0A1E4TBF1_9ASCO47.85%3263e-97Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_133455 PE=3 SV=1
A0A167C4G9_9ASCO59.05%2104e-84DNA-(Apurinic or apyrimidinic site) lyase APN1 OS=Sugiyamaella lignohabitans GN=APN1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9432
Predicted cleavage: 19

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 382

Detailed signature matches

  1. Family IPR001719
    AP endonuclease 2
    1. TIGR00587
    2. cd00019 (AP2Ec)
    3. MF_00152 (Nfo)
    4. PS51432 (AP_NUCLEAS...)
    5. SM00518 (ap2real3)
  2. Domain IPR013022
    Xylose isomerase-like, TIM barrel domain
    1. SSF51658 (Xylose is...)
    2. PF01261 (AP_endonuc_2)
  3. SITE IPR018246
    AP endonuclease 2, zinc binding site
    1. PS00730 (AP_NUCLEAS...)
    2. PS00729 (AP_NUCLEAS...)
    3. PS00731 (AP_NUCLEAS...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.20.20...
  2. mobidb-lite (disord...)

Residue annotation

  1. AP (apurinic/apyri...
  2. DNA interaction c...
  3. Metal-binding acti...

Protein sequence

>MCA_04217_1
MVAKSSSQKVIAKAFTRTEGVKYLIGAHVSTSEGVENSVERAVNLGCNGFAFFPKNQRRWSSNPYKPSNIENFKTACSHH
NFNSRTDVLPHGSYLINLGNPDPAKRKQAQTSFEDDLQRCEQLNVGLYNLHPGSAVGGADKTQTIKHIATGINQAIKQTQ
FVKVVLENMAGHGHIIGSDLQDLADIISQVEDKSRVGVCIDTCHAFAAGYDIRDEDSFTKFWQKFETIVGYEYLAGIHLN
DSKAPLGSKRDLHQNIGLGFLGLETFRLMVNKKELEGIPMILETPVDEKKVAKEGVSADLRGDEIKLLEWLIGKEKDDKE
VLEKSKELQEKGAKERKEHQEKFDKKNKEKKKNDDDDDDEGTVGKKRKKKNVEDFFSSAKKK

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.