MIA_02307_1

Protein

Length

2,211 amino acids

Protein function

EGGNOG:	0PG23	DYRK	CMGC DYRK DYRK2 protein kinase
SGD closest match:	S000003677	YAK1	Dual specificity protein kinase YAK1
CGD closest match:	CAL0000181204	orf19.5253	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MCA_04233_1	62.500%	600	0.0	MCA_04233_1
A0A0J9XGD6_GEOCN	60.453%	574	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA14s03178g PE=4 SV=1
UniRef50_A0A0J9XGD6	60.453%	574	0.0	Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGD6_GEOCN
A0A060T4B7_BLAAD	67.910%	402	0.0	ARAD1C40084p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C40084g PE=4 SV=1
A0A167FSF8_9ASCO	64.020%	403	1.19e-179	Serine/threonine protein kinase YAK1 OS=Sugiyamaella lignohabitans GN=YAK1 PE=4 SV=1
A0A1E3PCE4_9ASCO	47.789%	475	2.00e-142	Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_63103 PE=3 SV=1
Q6CAC2_YARLI	51.491%	369	5.87e-120	YALI0D04114p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04114g PE=4 SV=1
A0A1E4TLT7_9ASCO	52.528%	356	1.38e-122	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20444 PE=3 SV=1
Q5A3L7_CANAL	43.827%	324	1.84e-84	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5253 PE=4 SV=1
YAK1_YEAST	39.798%	397	7.93e-76	Dual specificity protein kinase YAK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YAK1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1383

Protein family membership

None predicted.

Domains and repeats

Domain
1,555 - 1,868
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 500 1000 1500 2211

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,555 - 1,868
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  1,567 - 1,863
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  1,567 - 1,863
  
  Pfam
  PF00069 (Pkinase)
3. SM00220 (serkin_6)
  
  1,567 - 1,863
  
  SMART
  SM00220 (serkin_6)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  1,573 - 1,596
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  1,689 - 1,701
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

Coil

1,438 - 1,461

COILS
Coil (Coil)

772 - 792

COILS
Coil (Coil)

803 - 928

COILS
Coil (Coil)

723 - 753

COILS
Coil (Coil)
G3DSA:1.10.51...

1,666 - 1,869

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

1,431 - 1,665

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd14210 (PKc_DYRK)

1,553 - 1,863

CDD
cd14210 (PKc_DYRK)
mobidb-lite (disord...)

1,869 - 1,891

MobiDB Lite
mobidb-lite (disorder_prediction)

1,377 - 1,423

MobiDB Lite
mobidb-lite (disorder_prediction)

32 - 103

MobiDB Lite
mobidb-lite (disorder_prediction)

122 - 309

MobiDB Lite
mobidb-lite (disorder_prediction)

1,909 - 2,116

MobiDB Lite
mobidb-lite (disorder_prediction)

936 - 967

MobiDB Lite
mobidb-lite (disorder_prediction)

704 - 759

MobiDB Lite
mobidb-lite (disorder_prediction)

777 - 811

MobiDB Lite
mobidb-lite (disorder_prediction)

422 - 493

MobiDB Lite
mobidb-lite (disorder_prediction)

336 - 394

MobiDB Lite
mobidb-lite (disorder_prediction)

1,280 - 1,346

MobiDB Lite
mobidb-lite (disorder_prediction)

1,145 - 1,169

MobiDB Lite
mobidb-lite (disorder_prediction)

663 - 689

MobiDB Lite
mobidb-lite (disorder_prediction)

2,128 - 2,211

MobiDB Lite
mobidb-lite (disorder_prediction)

1,072 - 1,092

MobiDB Lite
mobidb-lite (disorder_prediction)

530 - 553

MobiDB Lite
mobidb-lite (disorder_prediction)

1,224 - 1,249

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,573L

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,574G

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,575K

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,576G

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,577S

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,581V

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,594A

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,596K

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,630I

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,646T

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,647E

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,648L

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,649L

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,652N

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,693D

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,695K

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,697E

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,698N

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,700L

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)

1,713D

ATP binding site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D
CDD
cd14210 (PKc_DYRK)
active site cd14210

1,573L

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,574G

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,575K

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,576G

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,577S

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,581V

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,594A

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,596K

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,610V

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,630I

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,646T

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,647E

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,648L

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,649L

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,652N

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,654Y

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,655E

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,693D

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,695K

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,697E

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,698N

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,700L

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,713D

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,716S

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,725Y

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,727Y

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,728I

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,729Q

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,730S

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,732F

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,769G

active site
1,573L, 1,574G, 1,575K, 1,576G, 1,577S, 1,581V, 1,594A, 1,596K, 1,610V, 1,630I, 1,646T, 1,647E, 1,648L, 1,649L, 1,652N, 1,654Y, 1,655E, 1,693D, 1,695K, 1,697E, 1,698N, 1,700L, 1,713D, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)
polypeptide substr...

1,610V

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,654Y

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,693D

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,695K

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,716S

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,725Y

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,727Y

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,728I

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,729Q

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,730S

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,732F

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)

1,769G

polypeptide substrate binding site
1,610V, 1,654Y, 1,693D, 1,695K, 1,716S, 1,725Y, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,732F, 1,769G
CDD
cd14210 (PKc_DYRK)
activation loop (A...

1,712I

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,713D

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,714F

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,715G

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,716S

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,717S

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,718C

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,719Y

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,720E

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,721S

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,722E

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,723K

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,724V

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,725Y

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,726T

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,727Y

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,728I

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,729Q

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,730S

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,731R

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

1,732F

activation loop (A-loop)
1,712I, 1,713D, 1,714F, 1,715G, 1,716S, 1,717S, 1,718C, 1,719Y, 1,720E, 1,721S, 1,722E, 1,723K, 1,724V, 1,725Y, 1,726T, 1,727Y, 1,728I, 1,729Q, 1,730S, 1,731R, 1,732F
CDD
cd14210 (PKc_DYRK)

Protein sequence

>MIA_02307_1
MHSFQALPTDLGTQTSTVFKDDDGLKTRLLVSSPSVPSFPSYIPVSTSKTKLSTRLVNREPVGRQAALSSSYSGQSKSSS
SSVSNSPPSQFQNHQKTPSFSESTMPAFVSIKSRGLSFSFETSKGSAIPHRVSKQSEPEKNEHSSGFVKQHVNSGSPSNT
ALKSYPNLQKHSPSSLNSPPSKEPDTLASKQQNLSPNSHSEGKNPASFWNSPNNSKNSTSKTLPSHQNSRFSSSSITAPT
FSTLSKIKKPMPNSSIASTSVSSTTTKMTGNTPQKTQQATTQSSIITTPTTRSRFVNQTNEAARRSMPLLRSSNSFSNLI
SDYENMDSVENTNVSAYSNTDYSQTKTTKPQPKTHPYSQSNGFHMSTNNLDQTARPRQEPSLLTTSKLTDTNFSRNSSSI
DLQYIIPRIDNTTSLTSMDPPLAYSHRFSQPSSTNPSPTTSSFSLSSASIATNSSGTKSHRLSVGPGTLYSPKPRTRSSG
SPEPFISNNEEIPPVPPLPEELFIGPYSMNHSRFRDRSIITAANDSFSSSCNKLPSAQIQGGQNGPYPSSNKTKLQNRRS
IYGDFGISDIDKRDSSVTMASDFPISQGSIKTTGYQNHRQNIKNIHQSQYQHSNQRPIHNYRSVDNLKDFNDHRRMSAYA
SSVQSRRFSREVASFLSEYNDPVLHANNFDKPNVSQKSGSQEPKRGEPSLVEYDLYQRDEALEKQRQHQKLHQGYLSSHH
QQLHERLEQEKRLQESREKLERKEESKLEFNSNEYQRPENNRRASHLLQHDGQQFQQALEKQQRDLKQREQQPREKPLRE
QQHETQKRELQKYDKQRERLQREQLQLEQLQLEQQQHEKQQREKQLREKHLREKQQQQQLQQQQQYQQHQQQLQKLQHQQ
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQPQQQQQQQQQQQQPQPQQQQQQQQPLPQQQ
LQQQVDQKDYLDNDYEKHIPQTSSLKKEFLTDGSTSQNSLGLQTSHSELESLILSQNYLGNEIKQSPNHKKHPELTHRRS
SLLQQFGNLTISNSFASGLSKALDLDLETASKTSVNSTITSSSAESTSISLPTPPFTSSAFPTTSESTLNFNVENNVSSL
DPRNNPLKDYLSSSLSRMPNTTPRILTNEAEEKSGIQNQYPSKSTNQSQELYQTQNNELYSSGALIRKLSTRSIGSLRVP
VARKNSVSSFMTTSGLGLYDRKHISGQSQEKSDPPSLDPSRASSSMNLSKVVKSTTLNEFSIKSTASSLSLNRINMLNKT
DNSGIKVSPTKPSTSSFSSASITASPIRPTNWPSQIPPHSGIKAGLNTPKKLGTESGNGSPYDDTKIRSKSTVSKQWSNL
NLSTSAAKRLLFSPFSSDLRKSTNTPPSRKESPFSWKHGSTSNDHHYHKLVIPGSHSKDTDKESSVIMTPLLQQQLQAQA
KARALAQTQQAQQKLREQELQKEVEAIMRTLVHSIPEDEKVLRRYEESKKAGNLISTALTPSIAARTYRLNIYEKGEILD
FRNVYFTGRPDAKKISGDIRHAVNNYGFDDKNGDYYVVPGDHIAYRYEILSVLGKGSFGKVLKCIDHKNGKLVAVKMIIN
RKQFHLQALVEADILRTLTQWDPSDKYHLIRYTNHFNFREHLCICTELLGINLYELIKINKFKGLPLKLVRHFTQQILEA
LQFLDSKEIIHCDLKPENILLDDPAKGKVKIIDFGSSCYESEKVYTYIQSRFYRSPEVILGMVYNRKIDIWSMGCIVAEL
ITGQPLFMGENEQEQINCIMEVLGVPEVDMISQCSRRRLFFDSTGAPRPHVSSRNVKRFPGTKSLKRQLRTYDDKLVDFV
RQSLTWNPKHRLSPDSGLQHDFISSALPGSLNGSQSISNSTTRNEARRSTASILSVSNLPVIEPLVGQQQMQHIETQPRK
APQVPPTATTYGPVKVPVQNQVEAQSVSRRSSQISHSSSVGSFKSLLGMSTNQNPIRKKPADTKLDLNDTGVTHTNVSAP
SSGRPLPRVPGGANNSRDLSQQRNKPRNNFYVQGNGAHSSTHVYDHPIGPRPLVKGFGDAQSQNKPQRRVVSGDSSQVLK
HTRKSSVTSTASNGSTGGTEGTNKIKHTLGSFVTVRKPSIPRSFTMASLSSETPNKNNKADGSANPGNHVSSNARLKPAA
GHRVVSSSSLKDDRSQKSAVKLLPHSSSVSHNLHQRQHTPQQQHQQTPRWR

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component