MCA_04233_1

Protein

Length

1,636 amino acids

Gene name: YAK1B

Description: Serine/threonine protein kinase similar to Yak1; in S. cerevisiae component of a glucose-sensing system that inhibits growth in response to glucose availability.

Browser: contigC:2432543-2437943-

RNA-seq: read pairs 2658, FPKM 20.1, percentile rank 41.5% (100% = highest expression)

Protein function

Annotation:		YAK1B	Serine/threonine protein kinase similar to Yak1; in S. cerevisiae component of a glucose-sensing system that inhibits growth in response to glucose availability.
KEGG:	K18669	DYRK2_3_4	dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 [EC:2.7.12.1]
EGGNOG:	0PG23	DYRK	CMGC DYRK DYRK2 protein kinase
SGD closest match:	S000003677	YAK1	Dual specificity protein kinase YAK1
CGD closest match:	CAL0000181204	orf19.5253	Uncharacterized protein

Protein alignments

	%id	Aln length	E-value
MIA_02307_1	62.62%	602	0.0	MIA_02307_1
A0A0J9XGD6_GEOCN	65.87%	545	0.0	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA14s03178g PE=4 SV=1
UniRef50_A0A0J9XGD6	65.87%	545	0.0	Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGD6_GEOCN
A0A060T4B7_BLAAD	55.63%	577	0.0	ARAD1C40084p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C40084g PE=4 SV=1
A0A167FSF8_9ASCO	52.08%	576	0.0	Serine/threonine protein kinase YAK1 OS=Sugiyamaella lignohabitans GN=YAK1 PE=4 SV=1
A0A1E3PCE4_9ASCO	58.33%	372	4e-152	Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_63103 PE=3 SV=1
Q6CAC2_YARLI	51.21%	371	4e-119	YALI0D04114p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D04114g PE=4 SV=1
A0A1E4TLT7_9ASCO	51.97%	356	7e-118	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_20444 PE=3 SV=1
Q5A3L7_CANAL	48.24%	284	7e-85	Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5253 PE=4 SV=1
YAK1_YEAST	40.60%	367	6e-77	Dual specificity protein kinase YAK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YAK1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1334
Predicted cleavage: 35

Protein family membership

None predicted.

Domains and repeats

Domain
1,085 - 1,406
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 200 400 600 800 1000 1200 1400 1636

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,085 - 1,406
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  1,097 - 1,393
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. SM00220 (serkin_6)
  
  1,097 - 1,393
  
  SMART
  SM00220 (serkin_6)
3. PF00069 (Pkinase)
  
  1,097 - 1,393
  
  Pfam
  PF00069 (Pkinase)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  1,103 - 1,126
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  1,219 - 1,231
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

Coil

980 - 1,000

COILS
Coil (Coil)
G3DSA:1.10.51...

1,195 - 1,558

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

926 - 1,194

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd14210 (PKc_DYRK)

1,083 - 1,393

CDD
cd14210 (PKc_DYRK)
mobidb-lite (disord...)

1,401 - 1,440

MobiDB Lite
mobidb-lite (disorder_prediction)

510 - 619

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 110

MobiDB Lite
mobidb-lite (disorder_prediction)

146 - 192

MobiDB Lite
mobidb-lite (disorder_prediction)

335 - 397

MobiDB Lite
mobidb-lite (disorder_prediction)

1,488 - 1,552

MobiDB Lite
mobidb-lite (disorder_prediction)

778 - 897

MobiDB Lite
mobidb-lite (disorder_prediction)

1,597 - 1,636

MobiDB Lite
mobidb-lite (disorder_prediction)

453 - 496

MobiDB Lite
mobidb-lite (disorder_prediction)

643 - 761

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,103L

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,104G

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,105K

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,106G

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,107S

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,111V

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,124A

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,126K

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,160V

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,176T

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,177E

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,178L

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,179L

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,182N

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,223D

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,225K

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,227E

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,228N

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,230L

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)

1,243D

ATP binding site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D
CDD
cd14210 (PKc_DYRK)
active site cd14210

1,103L

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,104G

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,105K

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,106G

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,107S

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,111V

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,124A

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,126K

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,140V

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,160V

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,176T

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,177E

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,178L

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,179L

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,182N

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,184Y

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,185E

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,223D

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,225K

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,227E

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,228N

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,230L

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,243D

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,246S

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,255Y

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,257Y

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,258I

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,259Q

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,260S

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,262F

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,299G

active site
1,103L, 1,104G, 1,105K, 1,106G, 1,107S, 1,111V, 1,124A, 1,126K, 1,140V, 1,160V, 1,176T, 1,177E, 1,178L, 1,179L, 1,182N, 1,184Y, 1,185E, 1,223D, 1,225K, 1,227E, 1,228N, 1,230L, 1,243D, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)
polypeptide substr...

1,140V

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,184Y

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,223D

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,225K

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,246S

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,255Y

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,257Y

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,258I

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,259Q

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,260S

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,262F

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)

1,299G

polypeptide substrate binding site
1,140V, 1,184Y, 1,223D, 1,225K, 1,246S, 1,255Y, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,262F, 1,299G
CDD
cd14210 (PKc_DYRK)
activation loop (A...

1,242I

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,243D

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,244F

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,245G

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,246S

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,247S

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,248C

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,249F

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,250E

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,251S

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,252E

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,253K

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,254V

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,255Y

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,256T

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,257Y

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,258I

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,259Q

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,260S

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,261R

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

1,262F

activation loop (A-loop)
1,242I, 1,243D, 1,244F, 1,245G, 1,246S, 1,247S, 1,248C, 1,249F, 1,250E, 1,251S, 1,252E, 1,253K, 1,254V, 1,255Y, 1,256T, 1,257Y, 1,258I, 1,259Q, 1,260S, 1,261R, 1,262F
CDD
cd14210 (PKc_DYRK)

Protein sequence

>MCA_04233_1
MSALSTPPKDAYKTKIPLSSPLPPSSLPISVSRLSSFKSNPSNTFPDPKTSPRYINMTDASIKSRRFSLNIETPKTSSIP
LRVSRPAAASSTSSTTASQRHPTSSIPLSASLSNISNLQRSTKNPSLQSSSSINSQLNELNLNQEAVTNSKTPSPKKPIT
SLLGPKSNHDSPIHPKQSPRGASSSDRSQHSQIVVKSNGISLASSSSPSSSKNKTVFQNTAFSEQLKTRSKTSSGLSNST
ITKAQLPLHFQQTKTSNTVSHPARKSLPSLNLDMNFSTLTEEQLNVSPLDAFNAQGESAMMNFQNIIPRTDNTSALTTIG
HSSISITARGSRFGHLQNSHDQQQQQQQQTQVRNRSIQPPQPPKHGRSRGVTSPKPAVTSRPDEIPPVPPLPEEIFIGSH
PMTNRRFRNQANARRSMYVPHTTSMTSSQKTRKSMYGGLGLQMDYGNDNLYPNFQTNHPDRKPTATNQGTTSIPSPKQTV
TPKNGTVNAENPMPSTNHIQEAHQIPLYSSTQKPQYQQRTFSDVHHQPSSNNTKSQVNGPKPNPHPSVSIQNTTRLAQQK
NVHKSAPYSFTTTSKKQTQQTSLSINTNLHRQPSPNRLNSKNSTPDQELIPPVPQHFDFENSTKSIEKPYVKTPQHPFST
LSVQTSISKSDHEQEPSPNSTKGLSCSIPSGLSGSLTNRRHTTYQQQETSKMTTTSSPLNSKPESATSASNTQPRSSLSA
HSSSSTASTPQTFDSESSKSQHIESTPSSPIRPGNLIKPSSTSVSSLRLSIASYKSFTNGAESQPPTPTTKLLSTSSPCD
VTASNSSQVRTRSNTNTIVQTSEVSPYKSVSTELSKSSTNLLNNSPKPQQTKTPHSPYRPLNRPAHLYPPSNKPRESTTI
VNTESPADLKNEESKLRSKSTVAKQWSNFAGTNAKRLLLSPFSSEHRRASHAAKNISSKFNPQSNRVISLGSKNELGKVQ
AKAHVTSPSVLKPTGIRTSAKRISESLSDHEREIEKIMRSLNYTLPDSDKSQRRYEEAKKSGNLICEPMTPSVAARTFRL
NMYEKGEILDFRKVYFCGRSDTKKISGDIRHAVNNYGFDDKNGDYRVVPGDHIGYRYEILNVLGKGSFGKVLKCIDHKTG
KLVAVKMIINRKRFHLQAIVEAEILQTLSQWDSNDKYHLVKYTQHFNFREHLCICTELLGINLYELIKLNKFHGLPVKLV
RHFTQQILEGLRFLDNKEIIHCDLKPENILLEDPLRGKVKIIDFGSSCFESEKVYTYIQSRFYRSPEVILGMVYNRKIDI
WSMGCIVAELLTGQPLFMGENEQEQIACIMEVLGVPDLAMISLCSRRKLFFDYNGNPKIHTSSKNVKRYPGTRSLKKELK
TQDDSLVDFILQSLTWNPKHRMSPYQGLHHEFITGVPPPAPPAPVMSGRSSANSIRSRKSVKSNNSIPAIESPAQNGYRT
TSNTYVPMKVPSSQQQQQFTQSLDAQNVKLGMKQSSSMNNISQNVTSTLVSGPRVPSHAIDSNRRKTVMNPQGSYNSYNS
MGVNQAQLHQHQQHQQQQPQQQHRPLPILPPHRANRRQSVNLINNGASLQQKQSTHMAPNNLDPKSEACFNTTSTVADKN
TSQNMHAQPTTNHLAKSASEKHPYGYYLSDSNQNAF

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component