Protein

MIA_02296_1

Length
468 amino acids

Browser: contig03:378421-379910-

Protein function

EGGNOG:0PJBMERG8Phosphomevalonate kinase
SGD closest match:S000004833ERG8Phosphomevalonate kinase
CGD closest match:CAL0000200676ERG8Phosphomevalonate kinase

Protein alignments

%idAln lengthE-value
A0A0J9X946_GEOCN49.278%4852.47e-111Similar to Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase OS=Geotrichum candidum GN=BN980_GECA06s03046g PE=4 SV=1
A0A1E3PDI8_9ASCO43.737%4873.96e-94Phosphomevalonate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53135 PE=4 SV=1
UniRef50_A0A1E3PDI843.737%4871.07e-90Phosphomevalonate kinase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A1E3PDI8_9ASCO
A0A060T2C3_BLAAD44.206%4661.00e-91ARAD1A00770p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00770g PE=4 SV=1
A0A1D8PLH0_CANAL41.880%4683.61e-88Phosphomevalonate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG8 PE=4 SV=1
A0A167DY57_9ASCO43.750%4801.76e-85Phosphomevalonate kinase OS=Sugiyamaella lignohabitans GN=ERG8 PE=4 SV=1
Q6C6U3_YARLI42.333%4631.65e-79YALI0E06193p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E06193g PE=4 SV=1
MCA_04268_149.438%3563.98e-76MCA_04268_1
A0A1E4TCA5_9ASCO38.806%4691.25e-73Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138593 PE=4 SV=1
ERG8_YEAST37.551%4904.08e-67Phosphomevalonate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG8 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2671
Predicted cleavage: 38

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 468

Detailed signature matches

  1. Family IPR016005
    Phosphomevalonate kinase Erg8
    1. PIRSF017288 (PMK_GH...)
  2. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  3. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  4. Domain IPR006204
    GHMP kinase N-terminal domain
    1. PF00288 (GHMP_kinas...)
  5. Domain IPR013750
    GHMP kinase, C-terminal domain
    1. PF08544 (GHMP_kinas...)
    2. G3DSA:3.30.70...
  6. SITE IPR006203
    GHMP kinase, ATP-binding, conserved site
    1. PS00627 (GHMP_KINAS...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. TMhelix

Protein sequence

>MIA_02296_1
MSQKLAYSATGKALLAGGYLVLVPEYSAYVVALSARMHAVIQGSPASGNKTIVTARSPQFAQGEWRFEVNTSGPNAYQAV
VASNFPQNPFLEYAITVVLSYLQPIHNYNIDLTIYSDDGYHSQDEAKGDSDLRFHSHDLPIHKVPKTGLGSSAALTAAVT
AALLGFYRSLGIPLNAESPVPSPLDVSSRADLVLVHNLAQLAHCTAQGKIGSGFDVAAAVFGSLVYRRFPAAAIAAVADL
GHTARVSLGDDTIPQTAAYLNAVRELVDAPIDDTTGPWAPLQLEPCAMPRGLAVLMGDVRGGSETPKLVSTILQWRKDKP
EEAGRVWTALNAANMGVVSALAGLRALEQSMDQKAYDKMLADGEGLSDLKKQLRLVRKYLKEMTNLSQVPVEPEEQTQLL
DACAKLPGVVGGVVPGAGGYDAISLVVVASSISQLKEVSRDLPISWLDLREQSQGLIQEDPEHTQYHA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004631 phosphomevalonate kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.