Protein

MCA_04268_1

Length
590 amino acids

Gene name: ERG8

Description: Phosphomevalonate kinase

Browser: contigC:2541582-2543674+

RNA-seq: read pairs 2432, FPKM 50.8, percentile rank 65.7% (100% = highest expression)

Protein function

Annotation:ERG8Phosphomevalonate kinase
KEGG:K00938E2.7.4.2 phosphomevalonate kinase [EC:2.7.4.2]
EGGNOG:0PJBMERG8Phosphomevalonate kinase
SGD closest match:S000004833ERG8Phosphomevalonate kinase
CGD closest match:CAL0000200676ERG8Phosphomevalonate kinase

Protein alignments

%idAln lengthE-value
MIA_02296_149.44%3568e-87MIA_02296_1
A0A0J9X946_GEOCN46.83%3316e-81Similar to Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase OS=Geotrichum candidum GN=BN980_GECA06s03046g PE=4 SV=1
A0A1E3PDI8_9ASCO47.41%3488e-78Phosphomevalonate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53135 PE=4 SV=1
UniRef50_A0A1E3PDI847.41%3482e-74Phosphomevalonate kinase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A1E3PDI8_9ASCO
A0A060T2C3_BLAAD46.20%3422e-74ARAD1A00770p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A00770g PE=4 SV=1
A0A167DY57_9ASCO44.01%3344e-69Phosphomevalonate kinase OS=Sugiyamaella lignohabitans GN=ERG8 PE=4 SV=1
A0A1D8PLH0_CANAL43.23%3475e-68Phosphomevalonate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG8 PE=4 SV=1
Q6C6U3_YARLI41.92%3341e-65YALI0E06193p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E06193g PE=4 SV=1
A0A1E4TCA5_9ASCO38.55%3322e-56Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138593 PE=4 SV=1
ERG8_YEAST37.31%3353e-49Phosphomevalonate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG8 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0890

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 590

Detailed signature matches

  1. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  2. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  3. Domain IPR006204
    GHMP kinase N-terminal domain
    1. PF00288 (GHMP_kinas...)
  4. Domain IPR013750
    GHMP kinase, C-terminal domain
    1. PF08544 (GHMP_kinas...)
    2. G3DSA:3.30.70...
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. mobidb-lite (disord...)

Protein sequence

>MCA_04268_1
MTEVSSTTSQPLTSSESSKTIAFSAPGKALLAGGYLVLVPEYNAYVVALSSRMHALIQGKAASTNQDFTSVIARSPQFPE
GEWKFKVPITGSDAFQATPFDGSSNNPFIQATINVVLSYVQPKKNYNLEITIYSDDGYHSQDQTTDPTNELELEASDDLD
DHPSSSDTKASNEALFVDAHEPTEEAAAILQQSIDQANAQLKASTLEDTNSIKTGADKHANPSDKEQPKEQSIKKSDDAT
TKKSTITNSTRQNSRFHKHNLPIHKVPKTGLGSSAALTAVATACIYAFYLSEEGSKFDVSSRSHLDKIHNMAQVAHCTAQ
GKIGSGFDIASAVYGSIVYRRFPPEVVSSVIDTKASDEYCQAIKKLVDSPHGNKETWDSLRLENCSMPPGISVLMGDVRG
GSETPKLVGNVLQWRKENPEQALDIWKRLNTANMGLVSILDEMREFHNMNSDEYKELLRKHSRAANDPTPREPSSVSDNM
DLILLIKQHIREIRECLRAMGEASNVPIEPKSQTELLDRCTNELPGVLGGVVPGAGGFDAICLLVVSSCIEEIKNKSVEP
PLPITWLDLKEQPLGLMEEDPLHEDYSNLA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.