Protein

MIA_02198_1

Length
1,188 amino acids

Browser: contig03:104168-107735-

Protein function

EGGNOG:0PJBXRGR1Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
SGD closest match:S000004061RGR1Mediator of RNA polymerase II transcription subunit 14
CGD closest match:CAL0000182774MED14Mediator of RNA polymerase II transcription subunit 14

Protein alignments

%idAln lengthE-value
MCA_04253_148.515%12120.0MCA_04253_1
A0A0J9XCC9_GEOCN42.132%11630.0Similar to Saccharomyces cerevisiae YLR071C RGR1 Subunit of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA09s00615g PE=4 SV=1
UniRef50_A0A0J9XCC942.132%11630.0Similar to Saccharomyces cerevisiae YLR071C RGR1 Subunit of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCC9_GEOCN
A0A167D2Y4_9ASCO40.673%6542.08e-132Rgr1p OS=Sugiyamaella lignohabitans GN=RGR1 PE=4 SV=1
A0A060SWA2_BLAAD47.631%4011.13e-117ARAD1A03058p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03058g PE=4 SV=1
A0A1E3PIR1_9ASCO44.146%4105.01e-104MED14-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_66281 PE=4 SV=1
MED14_YARLI35.971%4171.39e-85Mediator of RNA polymerase II transcription subunit 14 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RGR1 PE=3 SV=1
A0A1E4TIE3_9ASCO30.324%4328.51e-57Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71762 PE=4 SV=1
MED14_CANAL34.615%3381.52e-44Mediator of RNA polymerase II transcription subunit 14 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MED14 PE=3 SV=3
MED14_YEAST28.763%3721.68e-33Mediator of RNA polymerase II transcription subunit 14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGR1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0429

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR013947
    Mediator complex, subunit Med14
    1. PF08638 (Med14)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Protein sequence

>MIA_02198_1
MATNVRPPNSNVSSIAALEQQPQSAQSLDKTPPSIPHITDNYITLKTIIANLVLFTHKEFKNIFETLPATTSDIAKKRRL
LDFIVKIRTEFVKVYVLTKWARISKDISKTIDVVSWLNGQQFCFRNVVSALFGIEKALAGAKLRTPDIETALEVFTAGRP
AQSSRNYFPVKKLDPSTILQTLHDLDILLSIRLALTEKLPPEFSHYKISDGRVTFFVENSYQVQLGIADDSVNARFFLVD
FKFDFPGAFNISAKTKARLELVSNDILPRKGLVDFFAMLLKFTQNYKLSTYHASLNELRRGLYADLILSKFSPEKSLVTV
QYWLTSKPGFSVASSSLSHPSNNNTGNNQSGISATASSAISGYQTLRNAIHIGISKNTNKIGVLWYRDSQLVTNHGLEFG
QSQETVESLLQRVASLHVQYIIQNVFLALSKMLEYNNTSTTIGKKSHVINHQSASSSQAPVSSSLSSSISSKNCKVISTQ
KSIYLQQTRNDVASSPQSPSGIAASTPNTPAHTSETFKVSTNELFNADPSHHEIVTMITPEKLKIRLSSTRFTIFSIDRL
TGKAILTNSTNLVSSAEAAINEAQGRSTIIAEILIKLRLSSIQEEICNKAKVTGWITKKNIHPSIVRNKFPPNTRLIFFL
RQSTWPDKWFLLVTLNTLGIPRWWITQMVFKDNSWHVLFSEEASIPNEELGKNYNYKMFVELDQFTVSRIRTEALRKELD
RCKIQYRLVQSTNTNSDAKSSHTDTLTEADSLNVSSRTIFDSSDSLPIAMFDISSIGEGFKWVEKAAYMRVGDVNDEKGT
VEVIVQGHTKNIFSIGIMPSDDPTIKFNPNTGMFSLFLTVNSSAFSLSAPIQANIQENSQSKPTSELLSLILQKLSRIQT
IVSHISLLKSLSLIIIEASMSKIVFEYGPNMRASILIALDEDVIKNNIAGNETSHIKKDVSDQQKRFTTTTSNSKHGFVF
KLHKNSPHKIVEPFLKKVINAEGLGSVVWILRKCLPLYSALQELQEGRLIQPSDSNGNPTSQRSSNRSFNTVMVFAHSLL
DFVIQFFGPSGRVYIQLKLIQSNHRPLSVFVSEFFFRDPVYVPSISTPLTSDELENQSKLLFAPLLPLWREKSDIPGVIP
LQQGLSCPIEKIKAVLMKITAIITQPASALAQPVGASGNVNGNSTVVLSSGTPSIQGGNKRSNLTGTS

GO term prediction

Biological Process

GO:0006357 regulation of transcription from RNA polymerase II promoter

Molecular Function

GO:0001104 RNA polymerase II transcription cofactor activity

Cellular Component

GO:0016592 mediator complex