Protein
MCA_04253_1
Length
1,174 amino acids
Gene name: RGR1
Description: Mediator of RNA polymerase II transcription subunit 14
Browser: contigC:2496302-2499827-
RNA-seq: read pairs 2152, FPKM 22.6, percentile rank 44.7% (100% = highest expression)
Protein function
| Annotation: | RGR1 | Mediator of RNA polymerase II transcription subunit 14 | |
|---|---|---|---|
| KEGG: | K15156 | MED14 | mediator of RNA polymerase II transcription subunit 14 |
| EGGNOG: | 0PJBX | RGR1 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors |
| SGD closest match: | S000004061 | RGR1 | Mediator of RNA polymerase II transcription subunit 14 |
| CGD closest match: | CAL0000182774 | MED14 | Mediator of RNA polymerase II transcription subunit 14 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02198_1 | 48.26% | 1208 | 0.0 | MIA_02198_1 |
| A0A0J9XCC9_GEOCN | 47.60% | 918 | 0.0 | Similar to Saccharomyces cerevisiae YLR071C RGR1 Subunit of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA09s00615g PE=4 SV=1 |
| UniRef50_A0A0J9XCC9 | 47.60% | 918 | 0.0 | Similar to Saccharomyces cerevisiae YLR071C RGR1 Subunit of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XCC9_GEOCN |
| A0A167D2Y4_9ASCO | 41.36% | 602 | 1e-124 | Rgr1p OS=Sugiyamaella lignohabitans GN=RGR1 PE=4 SV=1 |
| A0A060SWA2_BLAAD | 51.60% | 376 | 3e-116 | ARAD1A03058p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A03058g PE=4 SV=1 |
| A0A1E3PIR1_9ASCO | 48.63% | 366 | 7e-100 | MED14-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_66281 PE=4 SV=1 |
| MED14_YARLI | 42.40% | 375 | 2e-87 | Mediator of RNA polymerase II transcription subunit 14 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RGR1 PE=3 SV=1 |
| A0A1E4TIE3_9ASCO | 33.79% | 367 | 3e-57 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_71762 PE=4 SV=1 |
| MED14_CANAL | 33.70% | 368 | 6e-45 | Mediator of RNA polymerase II transcription subunit 14 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MED14 PE=3 SV=3 |
| MED14_YEAST | 30.29% | 373 | 3e-32 | Mediator of RNA polymerase II transcription subunit 14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGR1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0670
Protein family membership
- Mediator complex, subunit Med14 (IPR013947)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MCA_04253_1 MAAVHNLSENSVAARDFNSNLNQHSKVVNSNDPSNNQDDSNSTEASPPPIPHVTNNFISLRTVISNLVLFTHKELRNLLE TLPATTSDNAKKRRLLDFLVKIRIQFVKVYVLTKWAKVSKDISKTIDVVSWLTSQQNCFHNVILTLFTIEKDLGGAKLRA PDIETALEVFTAGRPSLPSLGFFPQKKLDSATVLQTLHDLDILLSIRLALTEKLPPKFSHYKIADGRVTFFVENCYQVQV GIADDSVDARFFLVDFKFDFPGAFRPSELTKARLESAANDILAKRGLEALFETLLTFTQNYKLSTYHLKVLELSNSIYSG LISSKFYPDKSLVTINYWLHPKTRTSRNFINIGILKQDKQIGISWIRDGQLVLNHNVEFGHPGCSVKQLLQDITSCHVQH IVTNVFNSLARYIELGNASQNNAHTSNDSNNDNSSSSNQQRSIYLQPPNSHESMNSPQSQSPSAQTASTPNTPASDLQGP NSENYYSSDVYGYEIVSLISPEKIKIMLTGTKFTIFSVDRLTGKTFLTNPNKLIASFEAIINEVYGRTNAIAELLIKLRL SSIQDEICSKAKATGLIAKTNMPIHSSVVRTKFPPHTRIIFCLRDSSWPAKWFLLVSLNTNGIPKWWISQTVLKDGYWSI LFSEELSISHEINQKYTYQMFDELNTFIINRIRTEALRKQLDRFKVNYRLIQSDNTNADDNEEAIIDEEEDDSSSNQVKD SLPIAILDLPSICGVDSQWAEDAIYMHLDSQEDNTDTINVLIYGKIKESFDINTMPRDDPCLTISFDTGKYTISLVTSSI SIPVNTQSKVGTQTSELIENIREKFAQVERIASHVNLLKNLSLNILEASMSKITFEYAPSLVASLILPERSNETGYVKSE GKTPNTSNTGSNNKQFILELKEDSPHKIVAHLLQEVLNNDGLLPVVWAMKKALPLYLALQELMEKGPKPLTIADFLPPDE NGSNTNGIKKQDGSTPFEGSANTPGSNGVVQTSSNYSSPTNVMQSPSVNMANTPSSSVSSSTAHTRPIIIIAHSLLDFTI QFVRSPRRIYLQLKLIESNGRPLQVFVSEAFLYHPFLSPVPTGPMHATHHQQLQQQLNTVSPPKLVNLWRQKVNNTSNNN NNNSGDEPSSKSEDQNNNNDLKIPRGVVPLQQGLSCPIESIQEVMRLVYEAIMG
GO term prediction
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
Molecular Function
GO:0001104 RNA polymerase II transcription cofactor activity
Cellular Component
GO:0016592 mediator complex