Protein

MIA_02037_1

Length
754 amino acids

Browser: contig02:2436760-2439025-

Protein function

EGGNOG:0PHG7PGUG_05644Mitochondrial inner membrane AAA protease Yta12
SGD closest match:S000004695YTA12Mitochondrial respiratory chain complexes assembly protein YTA12
CGD closest match:CAL0000178083orf19.2057M-AAA protease subunit

Protein alignments

%idAln lengthE-value
MCA_04534_188.284%6060.0MCA_04534_1
A0A0J9X4K4_GEOCN82.975%6050.0Similar to Saccharomyces cerevisiae YER017C AFG3 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease OS=Geotrichum candidum GN=BN980_GECA03s00747g PE=3 SV=1
UniRef50_A0A0J9X4K482.975%6050.0Similar to Saccharomyces cerevisiae YER017C AFG3 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease n=2 Tax=saccharomyceta TaxID=716545 RepID=A0A0J9X4K4_GEOCN
A0A1E4TLX6_9ASCO73.737%5940.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30822 PE=3 SV=1
A0A1E3PEY3_9ASCO68.914%6080.0ATP-dependent metallopeptidase Hfl OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27809 PE=3 SV=1
YTA12_YEAST66.443%5960.0Mitochondrial respiratory chain complexes assembly protein YTA12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YTA12 PE=1 SV=2
A0A060THA2_BLAAD69.064%5980.0ARAD1D37180p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37180g PE=3 SV=1
Q5AD10_CANAL66.834%5970.0M-AAA protease subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2057 PE=3 SV=1
Q6CHB1_YARLI66.777%6020.0YALI0A10615p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10615g PE=3 SV=1
A0A167EQJ4_9ASCO67.114%5960.0M-AAA protease subunit YTA12 OS=Sugiyamaella lignohabitans GN=YTA12 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9971
Predicted cleavage: 108

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 754

Detailed signature matches

  1. Family IPR005936
    Peptidase, FtsH
    1. MF_01458 (FtsH)
    2. TIGR01241
  2. Domain IPR011546
    Peptidase M41, FtsH extracellular
    1. PF06480 (FtsH_ext)
  3. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  4. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  5. Domain IPR003959
    ATPase, AAA-type, core
    1. PF00004 (AAA)
  6. Domain IPR000642
    Peptidase M41
    1. PF01434 (Peptidase_M41)
  7. SITE IPR003960
    ATPase, AAA-type, conserved site
    1. PS00674 (AAA)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:1.10.8.60
  3. G3DSA:3.40.50...
  4. NON_CYTOPLASM... (N...)
  5. SSF140990 (FtsH pro...)
  6. TRANSMEMBRANE (Tran...)
  7. cd00009 (AAA)
  8. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MIA_02037_1
MARAPLFQPQTAVNAARATWSRHSAKALLTVGPAHRRLLSSSHSSILSSHKLRTQTPTLKSTQRHHHHHPLILLQQSWAL
NQKLALPSSFTNRNAAIRLFHSSRSTLDEKPAASNNKTPQPQPPNQNLYTIIGLMLIGMFLLHLTTESLSPALTWEEFRT
NFLDRGLVQKITVVNRSVARVELRHGASSSAFSGNAPTVVFFTIGSVDSFERKLEEAQNELGIPSSERVPVFYTTEGSLM
SSLFAFLPTILLIAGIWYISKRGAQGLGGGGGIFGVGKSKAKLFNQETDIKVKFKDVAGMDEAKVEIMEFVNFLKDPKKY
ERLGAKIPRGAILSGPPGTGKTLVAKATAGEAGVPFLSVSGSEFVEMFVGVGASRVRDLFKTARKMAPSIIFIDEIDAIG
KARGQGGSFGGNDERESTLNQLLVEMDGFSSSDHVVVLAGTNRPDILDPALLRPGRFDRHISIDKPDIEGRKAIFQVYLA
KIKTQLDIKDLSGRLAALTPGFAGADVANCVNEAALIAARKGAHYVLIEHFEQAIERVIAGLEKKSRVLSAEERRTVAYH
EAGHAICGWYFKFADPLLKVSIIPRGQGALGYAQYLPPDLQLLSTEELSDRMAMTLGGRVSEEIHFDTVTSGASDDFKKV
TAMASNMVLRWGMSEQVGWLNYADSNDSQFSKPFSEKTGELIDNEVRRIVEEAHAKCDKLLRSKLPEIKKVAEELLTKEV
ITREDMIRLLGPRPFPERNDAFDKYLDKTKLNKH

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding

Cellular Component

GO:0016020 membrane
GO:0016021 integral component of membrane