MCA_04534_1
Gene name: AFG3
Description: AAA family ATPase; similar to S. cerevisiae Afg3p, a subunit of the mitochondrial inner membrane m-AAA protease
Browser: contigC:3304698-3306972+
RNA-seq: read pairs 16733, FPKM 272.8, percentile rank 91.2% (100% = highest expression)
Protein function
| Annotation: | AFG3 | AAA family ATPase; similar to S. cerevisiae Afg3p, a subunit of the mitochondrial inner membrane m-AAA protease | |
|---|---|---|---|
| KEGG: | K08956 | AFG3 | AFG3 family protein [EC:3.4.24.-] |
| EGGNOG: | 0PHG7 | PGUG_05644 | Mitochondrial inner membrane AAA protease Yta12 |
| SGD closest match: | S000004695 | YTA12 | Mitochondrial respiratory chain complexes assembly protein YTA12 |
| CGD closest match: | CAL0000201237 | AFG3 | AAA family ATPase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02037_1 | 79.75% | 711 | 0.0 | MIA_02037_1 |
| A0A0J9X4K4_GEOCN | 81.58% | 619 | 0.0 | Similar to Saccharomyces cerevisiae YER017C AFG3 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease OS=Geotrichum candidum GN=BN980_GECA03s00747g PE=3 SV=1 |
| UniRef50_A0A0J9X4K4 | 81.58% | 619 | 0.0 | Similar to Saccharomyces cerevisiae YER017C AFG3 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease n=2 Tax=saccharomyceta TaxID=716545 RepID=A0A0J9X4K4_GEOCN |
| A0A1E4TLX6_9ASCO | 72.42% | 620 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30822 PE=3 SV=1 |
| A0A1E3PEY3_9ASCO | 67.47% | 621 | 0.0 | ATP-dependent metallopeptidase Hfl OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_27809 PE=3 SV=1 |
| A0A060THA2_BLAAD | 66.45% | 620 | 0.0 | ARAD1D37180p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37180g PE=3 SV=1 |
| Q6CHB1_YARLI | 65.29% | 631 | 0.0 | YALI0A10615p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10615g PE=3 SV=1 |
| Q5AJC2_CANAL | 61.50% | 678 | 0.0 | AAA family ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=AFG3 PE=3 SV=1 |
| YTA12_YEAST | 66.89% | 598 | 0.0 | Mitochondrial respiratory chain complexes assembly protein YTA12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YTA12 PE=1 SV=2 |
| A0A167EQJ4_9ASCO | 65.85% | 615 | 0.0 | M-AAA protease subunit YTA12 OS=Sugiyamaella lignohabitans GN=YTA12 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9090
Predicted cleavage: 96
Protein family membership
- Peptidase, FtsH (IPR005936)
Domains and repeats
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Domain
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Domain
Detailed signature matches
no IPR
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CYTOPLASMIC_D... (C...)
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-
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NON_CYTOPLASM... (N...)
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SSF140990 (FtsH pro...)
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TRANSMEMBRANE (Tran...)
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cd00009 (AAA)
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mobidb-lite (disord...)
Residue annotation
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Walker A motif cd0...
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ATP binding site c...
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Walker B motif cd0...
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arginine finger cd...
Protein sequence
>MCA_04534_1 MIRTHIWKSWGSSCRLTLSTCLSRPLQTSKSSVATICTKPFRVQTPTSIRQLSALQRTDSLITLNQKSTSIFQKQLLKNA YNVQVRLFHRSAKAYNNKQNDNNNSNNNKKPQQQPEIPKNSFLTVIGVTLGLFMLLNLFAESMSSNLTWEEFRTNFLDRG LVEKVTIVNRTVARVTLRHDQGLPGNVVTFNIGSIESFERKLEEAQNELGIPITERIPVTYATEGSLLNSLFAFLPTILL IAGIIYITRRGPQGLGGSGGIFGVGKSKAKLFNQETDIKVKFKDVAGMDEAKVEIMEFVQFLKTPKKYERLGAKIPRGAI LSGPPGTGKTLVAKATAGEAGVPFLSVSGSEFVEMFVGVGASRVRDLFKTARKMAPSIIFIDEIDAIGKKRGQGGAFGGN DEREATLNQLLVEMDGFSSSDHVVVLAGTNRPDILDPALLRPGRFDRHISIDKPDLEGRKSVFKVYLAKIKTNLDLEELS GRLAALTPGFAGADVANCVNEAALIAARKGAHTVTAEHFEQAIERVIAGLEKKSRVLSAEERKTVAYHEAGHAICGWFLK FADPLLKVSIIPRGQGALGYAQYLPPDLQLLSVEELSDRMAMTLGGRVSEEIHFNSVTSGASDDFKKVTAMASNMVLRWG MSPKVGWLNYADSNESQYSKPFSEKTGELIDREVRRIIDEAHDKCKKLLLSKMPEIEKVAQELLTKEVITREDMIRLLGP RPFPERNDAFDKYLDKSKLNPDEKDQGKNDGPEPVAA
GO term prediction
Biological Process
GO:0006508 proteolysis
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane