MIA_02023_1

Protein

Length

857 amino acids

Protein function

EGGNOG:	0PJJQ	HIS4	Histidine biosynthesis trifunctional protein
SGD closest match:	S000000535	HIS4	Histidine biosynthesis trifunctional protein
CGD closest match:	CAL0000177625	HIS4	Histidine biosynthesis trifunctional protein

Protein alignments

	%id	Aln length
MCA_05605_1	72.675%	871	MCA_05605_1
A0A0J9X7D2_GEOCN	67.321%	866	Histidine biosynthesis trifunctional protein OS=Geotrichum candidum GN=BN980_GECA03s06082g PE=3 SV=1
Q6CGV2_YARLI	61.538%	871	Histidine biosynthesis trifunctional protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A15950g PE=3 SV=1
A0A167F801_9ASCO	58.949%	894	Histidine biosynthesis trifunctional protein OS=Sugiyamaella lignohabitans GN=HIS4 PE=3 SV=1
UniRef50_A0A167F801	58.949%	894	Histidine biosynthesis trifunctional protein n=171 Tax=Fungi TaxID=4751 RepID=A0A167F801_9ASCO
A0A060TD23_BLAAD	61.279%	860	Histidine biosynthesis trifunctional protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20724g PE=3 SV=1
A0A1E3PN90_9ASCO	62.281%	798	Histidine biosynthesis trifunctional protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_22321 PE=3 SV=1
A0A1E4TAW2_9ASCO	67.359%	674	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28128 PE=3 SV=1
HIS2_YEAST	61.584%	669	Histidine biosynthesis trifunctional protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS4 PE=1 SV=3
A0A1D8PKY7_CANAL	53.086%	810	Histidine biosynthesis trifunctional protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2474

Protein family membership

Phosphoribosyl-ATP pyrophosphohydrolase-like (IPR021130)
- Phosphoribosyl-ATP pyrophosphohydrolase (IPR008179)

Histidinol dehydrogenase (IPR012131)
- Histidine biosynthesis trifunctional-protein (IPR016298)

Domains and repeats

Domain
219 - 290
Phosphoribosyl-AMP cyclohydrolase domain (IPR002496)
444 - 854
Aldehyde/histidinol dehydrogenase (IPR016161)

1 100 200 300 400 500 600 700 800 857

Detailed signature matches

IPR012131

Histidinol dehydrogenase
1. PF00815 (Histidinol_dh)
  
  441 - 853
  
  Pfam
  PF00815 (Histidinol_dh)
2. MF_01024 (HisD)
  
  426 - 853
  
  HAMAP
  MF_01024 (HisD)
3. PR00083 (HOLDHDRGNASE)
  
  675 - 694
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  555 - 581
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  620 - 645
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  653 - 674
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  745 - 770
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  454 - 478
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  787 - 805
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  590 - 616
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
4. cd06572 (Histidinol_dh)
  
  450 - 845
  
  CDD
  cd06572 (Histidinol_dh)
5. TIGR00069
  
  454 - 852
  
  TIGRFAMs
  TIGR00069 (TIGR00069)
IPR016298

Histidine biosynthesis trifunctional-protein
1. PIRSF001257 (HIS4)
  
  1 - 857
  
  PIRSF
  PIRSF001257 (HIS4)
IPR021130

Phosphoribosyl-ATP pyrophosphohydrolase-like
1. PF01503 (PRA-PH)
  
  299 - 377
  
  Pfam
  PF01503 (PRA-PH)
IPR008179

Phosphoribosyl-ATP pyrophosphohydrolase
1. TIGR03188
  
  297 - 375
  
  TIGRFAMs
  TIGR03188 (TIGR03188)
IPR002496

Phosphoribosyl-AMP cyclohydrolase domain
1. PD002610
  
  242 - 290
  
  ProDom
  PD002610 (PD002610)
2. PF01502 (PRA-CH)
  
  219 - 290
  
  Pfam
  PF01502 (PRA-CH)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  444 - 854
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR001692

Histidinol dehydrogenase, conserved site
1. PS00611 (HISOL_DEHY...)
  
  653 - 685
  
  PROSITE patterns
  PS00611 (HISOL_DEHYDROGENASE)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

293 - 382

GENE3D
G3DSA:1.10.287.1080 (G3DSA:1.10.287.1080)
G3DSA:3.40.50...

447 - 647

GENE3D
G3DSA:3.40.50.1980 (G3DSA:3.40.50.1980)

648 - 797

GENE3D
G3DSA:3.40.50.1980 (G3DSA:3.40.50.1980)
SSF101386 (all-alph...)

295 - 375

SUPERFAMILY
SSF101386 (all-alpha NTP pyrophosphatases)
SSF141734 (HisI-like)

193 - 298

SUPERFAMILY
SSF141734 (HisI-like)
cd11546 (NTP-PPase_...)

295 - 378

CDD
cd11546 (NTP-PPase_His4)

Residue annotation

metal binding site...

333E

metal binding site
333E, 336E, 349E, 352D
CDD
cd11546 (NTP-PPase_His4)

336E

metal binding site
333E, 336E, 349E, 352D
CDD
cd11546 (NTP-PPase_His4)

349E

metal binding site
333E, 336E, 349E, 352D
CDD
cd11546 (NTP-PPase_His4)

352D

metal binding site
333E, 336E, 349E, 352D
CDD
cd11546 (NTP-PPase_His4)
NAD binding site c...

476F

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

548Y

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

550P

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

551G

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

559T

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

580P

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

607G

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

608G

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

610Q

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

631P

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

632G

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

633N

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

635F

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

636V

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)

685H

NAD binding site
476F, 548Y, 550P, 551G, 559T, 580P, 607G, 608G, 610Q, 631P, 632G, 633N, 635F, 636V, 685H
CDD
cd06572 (Histidinol_dh)
dimerization inter...

500D

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

501V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

504A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

505L

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

507L

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

510A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

511N

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

514K

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

515F

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

518A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

519Q

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

527V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

529T

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

533V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

534I

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

535C

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

536S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

537R

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

540R

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

542I

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

554A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

555V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

556L

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

557P

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

558S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

626D

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

641M

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

645N

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

673A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

674F

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

677S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

678D

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

680L

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

681S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

682Q

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

684E

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

685H

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

756Q

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

761S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

765V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

766K

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

768V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

769D

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

770H

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

771A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

772G

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

773S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

774V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

775F

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

776V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

778P

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

780S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

781P

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

783S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

784C

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

785G

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

786D

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

787Y

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

789S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

791T

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

801A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

802K

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

804Y

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

805S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

806G

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

807V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

808N

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

810G

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

811T

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

814K

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

815H

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

816I

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

817T

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

818S

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

819Q

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

820E

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

821L

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

836V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

837A

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

839V

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

840E

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

841G

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

842L

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

843D

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

844G

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)

845H

dimerization interface
500D, 501V, 504A, 505L, 507L, 510A, 511N, 514K, 515F, 518A, 519Q, 527V, 529T, 533V, 534I, 535C, 536S, 537R, 540R, 542I, 554A, 555V, 556L, 557P, 558S, 626D, 641M, 645N, 673A, 674F, 677S, 678D, 680L, 681S, 682Q, 684E, 685H, 756Q, 761S, 765V, 766K, 768V, 769D, 770H, 771A, 772G, 773S, 774V, 775F, 776V, 778P, 780S, 781P, 783S, 784C, 785G, 786D, 787Y, 789S, 791T, 801A, 802K, 804Y, 805S, 806G, 807V, 808N, 810G, 811T, 814K, 815H, 816I, 817T, 818S, 819Q, 820E, 821L, 836V, 837A, 839V, 840E, 841G, 842L, 843D, 844G, 845H
CDD
cd06572 (Histidinol_dh)
product binding si...

556L

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

558S

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

660S

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

685H

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

751E

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

752H

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

782E

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

786D

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

787Y

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

793H

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

840E

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

842L

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

845H

product binding site
556L, 558S, 660S, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)
substrate binding ...

558S

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

660S

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

682Q

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

685H

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

751E

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

752H

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

782E

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

786D

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

787Y

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

793H

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

840E

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

842L

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)

845H

substrate binding site
558S, 660S, 682Q, 685H, 751E, 752H, 782E, 786D, 787Y, 793H, 840E, 842L, 845H
CDD
cd06572 (Histidinol_dh)
zinc binding site ...

682Q

zinc binding site
682Q, 685H, 786D, 845H
CDD
cd06572 (Histidinol_dh)

685H

zinc binding site
682Q, 685H, 786D, 845H
CDD
cd06572 (Histidinol_dh)

786D

zinc binding site
682Q, 685H, 786D, 845H
CDD
cd06572 (Histidinol_dh)

845H

zinc binding site
682Q, 685H, 786D, 845H
CDD
cd06572 (Histidinol_dh)
catalytic residues...

751E

catalytic residues
751E, 752H
CDD
cd06572 (Histidinol_dh)

752H

catalytic residues
751E, 752H
CDD
cd06572 (Histidinol_dh)

Protein sequence

>MIA_02023_1
MSFPLLPKTPFAQISSAQALAAPLGQLLVALTPDDDLTQVAAYIKTNFGVLEFFADLAGLDASVDSAIKLLDAGVYRVIV
SPALAADLVAAGVPSLRILAATAPESTEDSNVAGFVVSDTASLPAAKDLTTKLIPETGGAKHLYVSLPDSVSLKDATAVV
AASAIPIVSAAKLTREHADDKTQGKLPVAEFILAALSSDRPDGLFTTLVLDENQTALGLVYSSPESVKEALRTNTGVYQS
RRHGLWYKGATSGATQTLLSMGLDCDGDCLKVSVSQQDPGFCHNNTASCFGAYRGLLSLEQTLRARIASAPEGSYTKRLF
NDEKLLTAKILEEAEELATANTKDEIAWEAADLLYFAFAKVVKDGVSVADVMNNLDSKSYKISRRRGDAKPKYVKQVDEI
TKSQAAPAPAPAPAPEQPARIKMNCIDAATSSPEEIEKVLTRPVQKTSDIMKLVLPIINNVIENGDKALLEYAAKFEKVE
LKTPVISAPFPEELMRLPKDVKDALDLSIANVEKFHAAQLDKSELRVETVPGVICSRFARPIQSVGLYIPGGTAVLPSTA
LMLGVPAKVAGCKNIIFASPPRRDGTITPEIVYVAHKVGAKKIVLAGGAQAVAAMAYGTDSVPKVDKIMGPGNQFVTAAK
MYVQNDTRALVSIDMPAGPSEVLVVADKTANPAFVASDLLSQAEHGVDSQVILLAVDLTDAELDAIDNELEKQALALPRV
DIVRGSIAHSTTLRVKTHEQAMALSNQYAPEHLILQIADASTKWVKKVDHAGSVFVGPYSPESCGDYSSGTNHTLPTYGY
AKMYSGVNTGTFMKHITSQELTEEGLKAIGPAVMTVAAVEGLDGHKNAVKVRLDALN

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004399 histidinol dehydrogenase activity
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 phosphoribosyl-ATP diphosphatase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0051287 NAD binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features