MCA_05605_1

Protein

Length

869 amino acids

Gene name: HIS4

Description: Histidine biosynthesis trifunctional protein

Browser: contigD:1783847-1786457+

RNA-seq: read pairs 3904, FPKM 55.4, percentile rank 67.6% (100% = highest expression)

Protein function

Annotation:		HIS4	Histidine biosynthesis trifunctional protein
KEGG:	K14152	HIS4	phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase [EC:3.6.1.31 3.5.4.19 1.1.1.23]
EGGNOG:	0PJJQ	HIS4	Histidine biosynthesis trifunctional protein
SGD closest match:	S000000535	HIS4	Histidine biosynthesis trifunctional protein
CGD closest match:	CAL0000177625	HIS4	Histidine biosynthesis trifunctional protein

Protein alignments

	%id	Aln length
MIA_02023_1	73.25%	871	MIA_02023_1
A0A0J9X7D2_GEOCN	65.98%	873	Histidine biosynthesis trifunctional protein OS=Geotrichum candidum GN=BN980_GECA03s06082g PE=3 SV=1
A0A167F801_9ASCO	61.61%	844	Histidine biosynthesis trifunctional protein OS=Sugiyamaella lignohabitans GN=HIS4 PE=3 SV=1
UniRef50_A0A167F801	61.61%	844	Histidine biosynthesis trifunctional protein n=171 Tax=Fungi TaxID=4751 RepID=A0A167F801_9ASCO
A0A060TD23_BLAAD	62.47%	826	Histidine biosynthesis trifunctional protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B20724g PE=3 SV=1
Q6CGV2_YARLI	61.56%	835	Histidine biosynthesis trifunctional protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A15950g PE=3 SV=1
A0A1E3PN90_9ASCO	61.64%	803	Histidine biosynthesis trifunctional protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_22321 PE=3 SV=1
A0A1E4TAW2_9ASCO	68.86%	668	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28128 PE=3 SV=1
HIS2_YEAST	62.11%	673	Histidine biosynthesis trifunctional protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS4 PE=1 SV=3
A0A1D8PKY7_CANAL	53.11%	836	Histidine biosynthesis trifunctional protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0438

Protein family membership

Histidinol dehydrogenase (IPR012131)
- Histidine biosynthesis trifunctional-protein (IPR016298)

Phosphoribosyl-ATP pyrophosphohydrolase-like (IPR021130)
- Phosphoribosyl-ATP pyrophosphohydrolase (IPR008179)

Domains and repeats

Domain
230 - 301
Phosphoribosyl-AMP cyclohydrolase domain (IPR002496)
456 - 865
Aldehyde/histidinol dehydrogenase (IPR016161)

1 100 200 300 400 500 600 700 800 869

Detailed signature matches

IPR012131

Histidinol dehydrogenase
1. PF00815 (Histidinol_dh)
  
  453 - 864
  
  Pfam
  PF00815 (Histidinol_dh)
2. PR00083 (HOLDHDRGNASE)
  
  687 - 706
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  602 - 628
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  632 - 657
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  798 - 816
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  567 - 593
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  466 - 490
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  757 - 782
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
  
  665 - 686
  
  PRINTS
  PR00083 (HOLDHDRGNASE)
3. MF_01024 (HisD)
  
  438 - 864
  
  HAMAP
  MF_01024 (HisD)
4. cd06572 (Histidinol_dh)
  
  462 - 856
  
  CDD
  cd06572 (Histidinol_dh)
5. TIGR00069
  
  466 - 863
  
  TIGRFAMs
  TIGR00069 (TIGR00069)
IPR016298

Histidine biosynthesis trifunctional-protein
1. PIRSF001257 (HIS4)
  
  1 - 869
  
  PIRSF
  PIRSF001257 (HIS4)
IPR021130

Phosphoribosyl-ATP pyrophosphohydrolase-like
1. PF01503 (PRA-PH)
  
  310 - 386
  
  Pfam
  PF01503 (PRA-PH)
IPR008179

Phosphoribosyl-ATP pyrophosphohydrolase
1. TIGR03188
  
  309 - 386
  
  TIGRFAMs
  TIGR03188 (TIGR03188)
IPR002496

Phosphoribosyl-AMP cyclohydrolase domain
1. PD002610
  
  253 - 301
  
  ProDom
  PD002610 (PD002610)
2. PF01502 (PRA-CH)
  
  230 - 301
  
  Pfam
  PF01502 (PRA-CH)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  456 - 865
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR001692

Histidinol dehydrogenase, conserved site
1. PS00611 (HISOL_DEHY...)
  
  665 - 697
  
  PROSITE patterns
  PS00611 (HISOL_DEHYDROGENASE)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

305 - 393

GENE3D
G3DSA:1.10.287.1080 (G3DSA:1.10.287.1080)
G3DSA:3.40.50...

660 - 808

GENE3D
G3DSA:3.40.50.1980 (G3DSA:3.40.50.1980)

459 - 659

GENE3D
G3DSA:3.40.50.1980 (G3DSA:3.40.50.1980)
SSF101386 (all-alph...)

306 - 386

SUPERFAMILY
SSF101386 (all-alpha NTP pyrophosphatases)
SSF141734 (HisI-like)

205 - 317

SUPERFAMILY
SSF141734 (HisI-like)
cd11546 (NTP-PPase_...)

306 - 389

CDD
cd11546 (NTP-PPase_His4)
mobidb-lite (disord...)

410 - 431

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

metal binding site...

344E

metal binding site
344E, 347E, 360E, 363D
CDD
cd11546 (NTP-PPase_His4)

347E

metal binding site
344E, 347E, 360E, 363D
CDD
cd11546 (NTP-PPase_His4)

360E

metal binding site
344E, 347E, 360E, 363D
CDD
cd11546 (NTP-PPase_His4)

363D

metal binding site
344E, 347E, 360E, 363D
CDD
cd11546 (NTP-PPase_His4)
NAD binding site c...

488F

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

560Y

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

562P

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

563G

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

571T

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

592P

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

619G

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

620G

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

622Q

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

643P

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

644G

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

645N

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

647F

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

648V

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)

697H

NAD binding site
488F, 560Y, 562P, 563G, 571T, 592P, 619G, 620G, 622Q, 643P, 644G, 645N, 647F, 648V, 697H
CDD
cd06572 (Histidinol_dh)
dimerization inter...

512E

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

513I

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

516S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

517L

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

519L

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

522E

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

523N

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

526K

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

527F

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

530A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

531Q

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

539V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

541T

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

545V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

546I

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

547C

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

548S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

549R

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

552R

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

554I

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

566A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

567V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

568L

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

569P

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

570S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

638D

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

653M

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

657N

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

685A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

686F

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

689S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

690D

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

692L

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

693S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

694Q

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

696E

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

697H

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

768Q

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

773R

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

776V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

777S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

779V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

780D

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

781H

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

782A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

783G

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

784S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

785V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

786F

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

787V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

789A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

791S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

792P

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

794S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

795C

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

796G

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

797D

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

798Y

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

800S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

802T

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

812A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

813K

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

815Y

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

816S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

817G

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

818V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

819N

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

821G

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

822T

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

825K

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

826H

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

827I

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

828T

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

829S

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

830Q

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

831E

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

832L

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

847V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

848A

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

850V

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

851E

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

852G

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

853L

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

854D

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

855G

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)

856H

dimerization interface
512E, 513I, 516S, 517L, 519L, 522E, 523N, 526K, 527F, 530A, 531Q, 539V, 541T, 545V, 546I, 547C, 548S, 549R, 552R, 554I, 566A, 567V, 568L, 569P, 570S, 638D, 653M, 657N, 685A, 686F, 689S, 690D, 692L, 693S, 694Q, 696E, 697H, 768Q, 773R, 776V, 777S, 779V, 780D, 781H, 782A, 783G, 784S, 785V, 786F, 787V, 789A, 791S, 792P, 794S, 795C, 796G, 797D, 798Y, 800S, 802T, 812A, 813K, 815Y, 816S, 817G, 818V, 819N, 821G, 822T, 825K, 826H, 827I, 828T, 829S, 830Q, 831E, 832L, 847V, 848A, 850V, 851E, 852G, 853L, 854D, 855G, 856H
CDD
cd06572 (Histidinol_dh)
product binding si...

568L

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

570S

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

672S

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

697H

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

763E

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

764H

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

793E

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

797D

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

798Y

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

804H

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

851E

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

853L

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

856H

product binding site
568L, 570S, 672S, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)
substrate binding ...

570S

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

672S

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

694Q

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

697H

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

763E

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

764H

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

793E

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

797D

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

798Y

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

804H

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

851E

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

853L

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)

856H

substrate binding site
570S, 672S, 694Q, 697H, 763E, 764H, 793E, 797D, 798Y, 804H, 851E, 853L, 856H
CDD
cd06572 (Histidinol_dh)
zinc binding site ...

694Q

zinc binding site
694Q, 697H, 797D, 856H
CDD
cd06572 (Histidinol_dh)

697H

zinc binding site
694Q, 697H, 797D, 856H
CDD
cd06572 (Histidinol_dh)

797D

zinc binding site
694Q, 697H, 797D, 856H
CDD
cd06572 (Histidinol_dh)

856H

zinc binding site
694Q, 697H, 797D, 856H
CDD
cd06572 (Histidinol_dh)
catalytic residues...

763E

catalytic residues
763E, 764H
CDD
cd06572 (Histidinol_dh)

764H

catalytic residues
763E, 764H
CDD
cd06572 (Histidinol_dh)

Protein sequence

>MCA_05605_1
MSYPLIPKTSFANIKEAVEIAGPTGSVLISISSSDDLTSISSYIKSTFGSIEYYADFTALSDASVDLVIQFFDSGLFKAI
VSSSLATELIAAGVGPSRILVLHSESSLSKISPDSEANSGFVFEASSKTDLSAFKSLSSSVQKSLNPEGGAGALYFNFTG
SVSLDLATAVVSDLSAIPIIDIQYLTREHESVPEGKLPVASFILARLSSDRTDGLFTTLVVDENSISLGLVYSSDKSIKE
AIRTGTGVYQSRRHGLWYKGATSGATQKLISISLDCDGDCLRFTVEQKYPGFCHNNTSSCFGPYKGFPSLEQTLLARMQN
APQGSYTKRLFDDEKLLTAKILEEAEELATAKSKEEVSWEAADLLYFAYTKVIKEGVSFADVAKNLDFKSYKISRRRGDA
KPKFIEQVEKISNTESKPAAPAKEATPTEKQPIKMNVVDATSCSAEEIAKVLTRPVQKTSDIMKLVLPIINNVIENGDKA
LLEFAAKFEKVELKTPVIEAPFPPEMMQLSDEIRDSLDLSIENVRKFHAAQLDEKPLRVETAPGVICSRFARPIKSVGLY
IPGGTAVLPSTALMLGVPAMVAGCENIIFASPPRKDGTITPEIVYVAHKVGAKKIVLAGGAQAVASMAYGTESVPKVDKI
MGPGNQFVTAAKMYVQNDTRALVSIDMPAGPSEVLVIADNTANPAFVASDLLSQAEHGVDSQVILLAVDLTDEELKAIEV
ELEKQALALPRVDIVRGSIAHSTTLRVKTMEEAFKLSNEYAPEHLIIQIKDARKWVSKVDHAGSVFVGAFSPESCGDYSS
GTNHTLPTYGYAKMYSGVNTGTFMKHITSQELTEEGIKNIGPAVMCVAAVEGLDGHKNAVKVRLDSLKN

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004399 histidinol dehydrogenase activity
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 phosphoribosyl-ATP diphosphatase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0051287 NAD binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features