Protein

MIA_01964_1

Length
1,017 amino acids

Browser: contig02:2212201-2215255-

Protein function

EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000001703FRE2Ferric/cupric reductase transmembrane component 2
CGD closest match:CAL0000185898CFL4Ferric/cupric-chelate reductase

Protein alignments

%idAln lengthE-value
MCA_05460_150.000%6820.0MCA_05460_1
A0A0J9XIC4_GEOCN46.584%6440.0Similar to Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters OS=Geotrichum candidum GN=BN980_GECA19s01132g PE=4 SV=1
UniRef50_A0A0J9XIC446.584%6440.0Similar to Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIC4_GEOCN
Q6CF26_YARLI31.929%6171.01e-95YALI0B10846p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B10846g PE=4 SV=1
A0A1E3PIN1_9ASCO28.885%6373.84e-88Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83263 PE=4 SV=1
A0A167FY66_9ASCO30.049%6091.04e-83Fre2p OS=Sugiyamaella lignohabitans GN=FRE2 PE=4 SV=1
A0A060TAD4_BLAAD30.847%4961.12e-74ARAD1D26136p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D26136g PE=4 SV=1
A0A1D8PN54_CANAL26.718%6558.26e-69Ferric/cupric-chelate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFL4 PE=4 SV=1
A0A1E4TJY1_9ASCO28.339%6147.36e-68Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_81144 PE=4 SV=1
FRE2_YEAST26.855%5661.58e-59Ferric/cupric reductase transmembrane component 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1677

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 1017

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  5. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:2.40.30.10
  3. G3DSA:3.40.50.80
  4. NON_CYTOPLASM... (N...)
  5. SFLDG01168 (Ferric_...)
  6. SFLDS00052 (Ferric_...)
  7. SIGNAL_PEPTIDE (Sig...)
  8. SIGNAL_PEPTID... (S...)
  9. SIGNAL_PEPTID... (S...)
  10. SIGNAL_PEPTID... (S...)
  11. SSF52343 (Ferredoxi...)
  12. SignalP-noTM
  13. TMhelix
  14. TRANSMEMBRANE (Tran...)
  15. cd06186 (NOX_Duox_l...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MIA_01964_1
MLKLTLFPLLLPLLLSHTCLAQKVGVCSDLGLACWSAAAALNFGCPAPDSLPPREPQPTSSVQVDPISAYKCLCSSAPFL
QTYAYCIRSRMQEYSQISGGYLFLYRQCFYNADTAYSLGHFEDLYYNASSYISSQEYNNDLSVLTSTPHFVDTAQLMDAL
VSSQSLLEIPVAINNDTFSKQFKAASIAKTQYRMGSVYGTLLLCYWGLIIAVASIHRFIQQVYPEILFANNKQVNYLRKY
LILPATFKRNRSRPVKLLLSFYVCAPTRGQSLILVGYFVLTTVFLSIRYDIYQGNPITPGPKYQLLKYLGSRSGIMAFTQ
LPLVISFAARNSPLIWLTGWPYDTFQTYHRWTARVMMINILLHTACFMTIAVSGCTWVYRWEEIINWRFGNLATYSGVIM
ALVAINKFRAHFYETFLVIHKLFFFAFMVGIFRHCWDFGWMPWVYASIAIYFSERLGRIFKTTVSGVVSSAYAEVYEDNV
FRLTVHYSGRWNVQPGQYCYIRFLRRDLFWQAHPISVYAGPQDAGFPTLQFCVQAHNGATKTIAEHLAQQPDKNGKLRVM
VQGPYGVPQKIEVYDTVIFVAGGLGITAVYSYAQHLKRLGSSHQRQQQRVVVMWIVRSTAALEWFSEELAELGRSSYGST
GSWFDTQVYVTDSQSRSASQVDLSAMQAHVSGVTENNDEADERQPSQEFFPDLEHCETLTEARMQRDDSEATLSLEELDN
VEIGGRHYSQYPSQHDPQQAKRACIHSITTASSTSSLGAALHLPVKPSIIQKQRPESFAVPLTPTLDMREYQRYSVMQLQ
QQQEEEEPLSPKPIPKTPTTPYGMQRFALSDQSLSSELFNMGPLPSDRKYGLGKLDDKKGGLSNTSRIGAANTAVDDIGV
TRAPGFTVIHGKPDVRSEIARCLRENIGRRPRSAGAPGSLHGTGSVSASGNPYGFMPGMSEQDKSSGSRNGFCREGGCFK
EEEKHVEYSEEKKSMGKPLAVMSCGPPELVDSIRASIVEHLLDSEGRVDYFEEAFSW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.