Protein

MIA_01954_1

Length
238 amino acids

Browser: contig02:2184230-2185003-

Protein function

EGGNOG:0PFYZTIF6Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export (By similarity)
SGD closest match:S000006220TIF6Eukaryotic translation initiation factor 6
CGD closest match:CAL0000186684TIF6Eukaryotic translation initiation factor 6

Protein alignments

%idAln lengthE-value
MCA_04628_192.017%2381.58e-161MCA_04628_1
A0A0J9XGC5_GEOCN89.565%2303.08e-150Eukaryotic translation initiation factor 6 OS=Geotrichum candidum GN=TIF6 PE=3 SV=1
A0A060T9E2_BLAAD83.478%2301.48e-143Eukaryotic translation initiation factor 6 OS=Blastobotrys adeninivorans GN=TIF6 PE=3 SV=1
A0A1E3PIQ9_9ASCO79.661%2368.42e-140Eukaryotic translation initiation factor 6 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=TIF6 PE=3 SV=1
IF6_CANAL78.298%2353.17e-137Eukaryotic translation initiation factor 6 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TIF6 PE=3 SV=1
IF6_YEAST77.447%2357.98e-137Eukaryotic translation initiation factor 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIF6 PE=1 SV=1
UniRef50_Q1252277.447%2351.91e-133Eukaryotic translation initiation factor 6 n=190 Tax=Opisthokonta TaxID=33154 RepID=IF6_YEAST
A0A1E4TK47_9ASCO74.043%2352.57e-128Eukaryotic translation initiation factor 6 OS=Tortispora caseinolytica NRRL Y-17796 GN=TIF6 PE=3 SV=1
Q6C4C3_YARLI75.676%2227.11e-126Eukaryotic translation initiation factor 6 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TIF6 PE=3 SV=1
A0A167CSJ8_9ASCO88.021%1922.86e-126Eukaryotic translation initiation factor 6 OS=Sugiyamaella lignohabitans GN=TIF6 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5392
Predicted cleavage: 13

Protein family membership

Domains and repeats

None predicted.

Detailed signature matches

  1. Family IPR002769
    Translation initiation factor IF6
    1. SM00654 (eIF6neu2)
    2. cd00527 (IF6)
    3. PIRSF006413 (Transl...)
    4. MF_00032 (eIF_6)
    5. TIGR00323
    6. PF01912 (eIF-6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.75.10.10
  2. SSF55909 (Pentein)

Residue annotation

  1. "Velcro" closure c...

Protein sequence

>MIA_01954_1
MRAKSLTGSYRVGVFSKLTNSYSLVAIGGSQNFYSVFESQLQDVIPIVNTTIAGTRIIGRMTAGNRRGLLVPTQTTDQEL
QHLRNSLPDTVKIQRVEERLSALGNVICCNDYVALVHPDIERETEEIIADTLGVEVFRQTVAGNVLVGSYATITNQGGLV
HPQTSIQDQEELSSLLQIPIVAGSVNRGSPVIGSGLVANDWLAVVGMDTTAPELSVVESIFGLSNEAPEEGVLIEHYY

GO term prediction

Biological Process

GO:0042256 mature ribosome assembly

Molecular Function

GO:0043022 ribosome binding

Cellular Component

None predicted.