Protein
MCA_04628_1
Length
239 amino acids
Gene name: TIF6
Description: Eukaryotic translation initiation factor 6
Browser: contigC:3552560-3553506-
RNA-seq: read pairs 1916, FPKM 98.6, percentile rank 78.4% (100% = highest expression)
Protein function
| Annotation: | TIF6 | Eukaryotic translation initiation factor 6 | |
|---|---|---|---|
| KEGG: | K03264 | EIF6 | translation initiation factor 6 |
| EGGNOG: | 0PFYZ | TIF6 | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export (By similarity) |
| SGD closest match: | S000006220 | TIF6 | Eukaryotic translation initiation factor 6 |
| CGD closest match: | CAL0000186684 | TIF6 | Eukaryotic translation initiation factor 6 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_01954_1 | 92.02% | 238 | 1e-159 | MIA_01954_1 |
| A0A0J9XGC5_GEOCN | 87.03% | 239 | 4e-153 | Eukaryotic translation initiation factor 6 OS=Geotrichum candidum GN=TIF6 PE=3 SV=1 |
| A0A060T9E2_BLAAD | 81.59% | 239 | 4e-145 | Eukaryotic translation initiation factor 6 OS=Blastobotrys adeninivorans GN=TIF6 PE=3 SV=1 |
| A0A1E3PIQ9_9ASCO | 78.28% | 244 | 4e-141 | Eukaryotic translation initiation factor 6 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=TIF6 PE=3 SV=1 |
| IF6_YEAST | 77.87% | 244 | 1e-140 | Eukaryotic translation initiation factor 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIF6 PE=1 SV=1 |
| UniRef50_Q12522 | 77.87% | 244 | 3e-137 | Eukaryotic translation initiation factor 6 n=190 Tax=Opisthokonta TaxID=33154 RepID=IF6_YEAST |
| IF6_CANAL | 76.64% | 244 | 9e-139 | Eukaryotic translation initiation factor 6 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TIF6 PE=3 SV=1 |
| A0A1E4TK47_9ASCO | 75.00% | 244 | 2e-133 | Eukaryotic translation initiation factor 6 OS=Tortispora caseinolytica NRRL Y-17796 GN=TIF6 PE=3 SV=1 |
| Q6C4C3_YARLI | 76.62% | 231 | 3e-131 | Eukaryotic translation initiation factor 6 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=TIF6 PE=3 SV=1 |
| A0A167CSJ8_9ASCO | 85.94% | 192 | 2e-121 | Eukaryotic translation initiation factor 6 OS=Sugiyamaella lignohabitans GN=TIF6 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0415
Protein family membership
- Translation initiation factor IF6 (IPR002769)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
-
-
SSF55909 (Pentein)
Residue annotation
-
"Velcro" closure c...
Protein sequence
>MCA_04628_1 MSVRAQFENSNEIGVFSKLTNSYSLVTIGGSQNFYSVFESQLQDVIPIVNTTIAGTRIIGRMTAGNRRGLLVPTQTTDQE LQHLRNSLPDTVKIQRVEERLSALGNVICCNDYVALVHPDIERETEEIIADTLGVEVFRQTVAGNVLVGSYACITNQGGI VHPETSVQDQDELSSLLQIPIVAGSVNRGSPVVGSGMVANDFLAVVGMDTTAPELSVVESIFGLSNDAPEEGVLIEHYY
GO term prediction
Biological Process
GO:0042256 mature ribosome assembly
Molecular Function
GO:0043022 ribosome binding
Cellular Component
None predicted.