Protein

MIA_01923_1

Length
1,226 amino acids

Browser: contig02:2088624-2092305+

Protein function

EGGNOG:0PHHVATG1Serine threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes
SGD closest match:S000003148ATG1Serine/threonine-protein kinase ATG1
CGD closest match:CAL0000188572ATG1Serine/threonine-protein kinase ATG1

Protein alignments

%idAln lengthE-value
MCA_03494_158.526%4751.85e-157MCA_03494_1
A0A167DGH7_9ASCO66.269%3351.36e-140Serine/threonine protein kinase ATG1 OS=Sugiyamaella lignohabitans GN=ATG1 PE=4 SV=1
UniRef50_A0A167DGH766.269%3353.73e-137Serine/threonine protein kinase ATG1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167DGH7_9ASCO
A0A0J9XE19_GEOCN56.835%4176.62e-141Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA11s03827g PE=4 SV=1
A0A060T0R2_BLAAD65.476%3362.26e-132ARAD1C15004p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15004g PE=4 SV=1
A0A1E3PPL3_9ASCO61.818%3303.30e-123Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49685 PE=4 SV=1
ATG1_CANAL56.447%3498.63e-125Serine/threonine-protein kinase ATG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG1 PE=3 SV=2
ATG1_YARLI59.878%3291.76e-124Serine/threonine-protein kinase ATG1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG1 PE=3 SV=1
A0A1E4TM81_9ASCO51.988%3272.33e-103Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30816 PE=4 SV=1
ATG1_YEAST49.856%3471.58e-100Serine/threonine-protein kinase ATG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1619
Predicted cleavage: 15

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1226

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. Domain IPR022708
    Serine/threonine-protein kinase, C-terminal
    1. PF12063 (DUF3543)
  4. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  5. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. G3DSA:1.10.51...
  3. G3DSA:3.30.20...
  4. NON_CYTOPLASM... (N...)
  5. TRANSMEMBRANE (Tran...)
  6. cd14009 (STKc_ATG1_...)
  7. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd14009
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MIA_01923_1
MSDQPQVLSGTYRLGPEIGRGSFASVYKGQHLVSKAPVAVKSVHLARLNKKLLENLESEITILKRMTHPHIVALIDSYKT
PTHFFLIMEYCSLGDLSYFFKRRKEISDSLPLINSLFQRYPPPPHSNGLHEDLARHFLKQLASALEFLRQHHLVHRDIKP
QNLLLCPPKHTEQEAIDAGYKGLWELPVLKLADFGFARILPSTSMAETLCGSPLYMAPEILRLEKYTAKADLWSVGAVLF
EMVAGRPPFKASTHVNLLAQIEQMGDTINFPEGNTNSRDIKRLIRSLLKKDATQRMSFAEFFNDPVIVDDIRDADSLMEN
KPLDQSFLTDDLYIAEYIQLGPNNPRDRAELERHGMKQRLPPASNRQLHQGINNASNQQRHKEKQLHQPHYQENHQLTEI
TNWQQQQQEATKPYSNCKFNATLTNENPTVVPKSRDTSGRDGNNTGHTTPPSNSINEETNSSHTLPAPPTPPHSVPRTIN
DVEPVTSKDTHNQSDKTSTDDNSNNHTTNTSHLKTSSTPAANIPTFTVSSHSSTSSTSSFSERLSQQTNDQRQQQQQQPQ
PHSPKSFPYSSNSLGEASPSPSSSWLAQPLLQQHNKPQRRGPHFPEDNNDIHHHYLQHNHLQTNLNLETKPGPNKIYGSS
RNTFSSANNSNTSLNATKQHLHLATTTTPAFGAGAGAGANASNNSGKSRAFLKSTTTNSSSPSSSSPTGLFPRPLESEYV
VVEKRTVEVNSFADELTHSPVDHHHSKPSSRNNSVSSQSSNHAGSYQNQQYQYQYNQQQQQLQHRRNSSTRSSPGSAAVA
VAMAAASAAAASAAAVAAAAAGGTVARRHRNSSSSGAPGSGADFNNPHYLGQPPSPSTDTGLAKGVSRRLSIVHGSSPSN
ALARALSMASARLFGTRVTDSGDVLETSPPQFSQRVLSTTVDAEENRFVRHITSLATKAKAISIFAEVKYSQLLPSNGQG
GTSSDVDLSADAMVVVAHEALALYLKTLSLLSRIMKETSVWWKSRGGSGGIGDSGAPSSAGSLGSNNGGGSAGNSTAHTY
LSGGPPMASKQLIEQVQWIRDKFNESLDKAEYAQMQINKFSSNCTEAVLVHCKTLKAQDLIFYRAIEMSKSAAVSEAAFV
DLEGSEISYGTAIWMLQSLLEPDEEDHNTIDASERSRVVQVIETITRRLQVVRKKMAAQQQTGPNSGVGSSGATLGSTPT
GSLPRSLPHSPHGSTTTCPSPSQLNH

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.