Protein

MCA_03494_1

Length
990 amino acids

Gene name: ATG1

Description: Serine/threonine protein kinase Atg1; in S. cerevisiae required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway

Browser: contigC:119861-122834-

RNA-seq: read pairs 489, FPKM 6.1, percentile rank 19.2% (100% = highest expression)

Protein function

Annotation:ATG1Serine/threonine protein kinase Atg1; in S. cerevisiae required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway
KEGG:K08269ULK2 serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
EGGNOG:0PHHVATG1Serine threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes
SGD closest match:S000003148ATG1Serine/threonine-protein kinase ATG1
CGD closest match:CAL0000188572ATG1Serine/threonine-protein kinase ATG1

Protein alignments

%idAln lengthE-value
MIA_01923_172.59%3434e-168MIA_01923_1
A0A167DGH7_9ASCO64.69%3373e-151Serine/threonine protein kinase ATG1 OS=Sugiyamaella lignohabitans GN=ATG1 PE=4 SV=1
UniRef50_A0A167DGH764.69%3377e-148Serine/threonine protein kinase ATG1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167DGH7_9ASCO
A0A0J9XK72_GEOCN64.63%3285e-144Similar to Saccharomyces cerevisiae YMR001C CDC5 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation OS=Geotrichum candidum GN=BN980_GECA25s00901g PE=4 SV=1
A0A060T0R2_BLAAD65.06%3322e-142ARAD1C15004p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15004g PE=4 SV=1
A0A1E3PPL3_9ASCO61.42%3374e-135Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49685 PE=4 SV=1
ATG1_YARLI60.43%3261e-136Serine/threonine-protein kinase ATG1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG1 PE=3 SV=1
ATG1_CANAL59.20%3265e-130Serine/threonine-protein kinase ATG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG1 PE=3 SV=2
A0A1E4TM81_9ASCO52.80%3224e-110Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30816 PE=4 SV=1
ATG1_YEAST51.59%3452e-109Serine/threonine-protein kinase ATG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0159

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 990

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. Domain IPR022708
    Serine/threonine-protein kinase, C-terminal
    1. PF12063 (DUF3543)
  4. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  5. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd14009 (STKc_ATG1_...)
  4. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd14009
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MCA_03494_1
MSELHQQRDLGAYKVGGEIGRGSFANVYKGKHQASGAPVAIKSVLRARLNKRLLESLDHEISILKRITHPHIVSLIDFQQ
TNSHFYLIMEYCSLGDLSFFFRKRKELINSHPLIASLFQRYPPAPDNGLHEDLARHFLKQLASALEFLRENDLVHRDIKP
QNLLLCPPKKTEQEAKAAGYKALWELPVLKLADFGFARILPSTSMAETLCGSPLYMAPEILRLEKYNHKADLWSVGAVLY
EMVAGRPPFHAATHTDLLAQITKSQDVIEFPANNTSSQEIKRLIRALLKQDPTQRISYEEFLQDPVIVNDIHSPTRPLDR
SFVDEHLYVSEYIQLGPTNPLNLADIDKKQQKQRLLNQQKNTDQSNPSSNNNNNTTPINKKYNNQPMHNNKQKYKNTHQT
NTHAITSSNNTNTKQSTEHESSSSSSSSSYELKDITNKPMNLHVDTKQPSPSPPTPPHSMPKSSKVSRNDSINDGNTKSN
SSGYPQSPLSYGSRKMMEHSPSPGTSWLTQYQGKHSISPSSPKRGSVGGRKSNNSNNNNNGFGSIDESSNDPFNKPLESE
YVVVEKRTVEVNSFADELVHSPVERRQSSGNSQATLTQQQQQQQTSARNRRNSYARSSVNSQNYSGTSGIGISIAGRCHR
NSSGSETSGSSVPAQSSSIPERRYSIVHGSSPSNALTRALSMASARLFGTKISDTGDTTSTTPPKFAQRVVPPTVDSEEK
RLIRHLDSLTTKAKAINMFAEVKYTQIIPLDEADSNRDLSPDAMVIVAREALALYLKTLSLLSKVMNEASVWWKSRSSTE
NMSPSSKLIEMVQWIRDKFNESLEKAEYVKEQINKYSSLSSEAVVASGRNITAEKLVFDHAMEMAHSAAVCEMSNEDLED
CQLSYATAIWMLEALLESTDDDSEPLKEADRNLVTGLIDSLSGRLTTVRKKISQQALQYISFNSPSSPSLKEEGVVNNNN
NSVLNQNGQSSTTTTSSSSSTVQGTTTSTP

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.