MIA_01909_1

Protein

Length

353 amino acids

Browser: contig02:2047279-2048341+

Protein function

EGGNOG:	0PFKM		gtp cyclohydrolase i
SGD closest match:	S000003499	FOL2	GTP cyclohydrolase 1
CGD closest match:	CAL0000195996	orf19.3957	GTP cyclohydrolase I (Fragment)

Protein alignments

	%id	Aln length	E-value
MCA_01479_1	87.083%	240	1.20e-156	MCA_01479_1
A0A1E3PFG0_9ASCO	78.764%	259	2.71e-149	GTP cyclohydrolase I OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28058 PE=3 SV=1
A0A0J9X5V2_GEOCN	86.175%	217	2.21e-146	Similar to Saccharomyces cerevisiae YGR267C FOL2 GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway OS=Geotrichum candidum GN=BN980_GECA03s03651g PE=3 SV=1
A0A167EAT3_9ASCO	77.647%	255	1.51e-144	GTP cyclohydrolase I OS=Sugiyamaella lignohabitans GN=FOL2 PE=3 SV=1
Q6CHC2_YARLI	81.333%	225	4.64e-139	YALI0A10310p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10310g PE=3 SV=2
UniRef50_Q6CHC2	81.333%	225	1.07e-135	YALI0A10310p n=31 Tax=Opisthokonta TaxID=33154 RepID=Q6CHC2_YARLI
A0A060T8J3_BLAAD	68.821%	263	2.80e-126	ARAD1D07392p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07392g PE=3 SV=1
A0A1D8PP19_CANAL	74.153%	236	2.01e-125	GTP cyclohydrolase I (Fragment) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3957 PE=3 SV=1
A0A1E4TGX1_9ASCO	68.313%	243	7.11e-125	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_115382 PE=3 SV=1
GCH1_YEAST	69.957%	233	7.97e-119	GTP cyclohydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0328

Protein family membership

GTP cyclohydrolase I (IPR001474)

Domains and repeats

Domain
174 - 351
GTP cyclohydrolase I domain (IPR020602)

1 50 100 150 200 250 300 353

Detailed signature matches

IPR001474

GTP cyclohydrolase I
1. MF_00223 (FolE)
  
  170 - 352
  
  HAMAP
  MF_00223 (FolE)
2. TIGR00063
  
  174 - 353
  
  TIGRFAMs
  TIGR00063 (TIGR00063)
IPR020602

GTP cyclohydrolase I domain
1. PF01227 (GTP_cycloh...)
  
  174 - 351
  
  Pfam
  PF01227 (GTP_cyclohydroI)
IPR018234

GTP cyclohydrolase I, conserved site
1. PS00860 (GTP_CYCLOH...)
  
  279 - 289
  
  PROSITE patterns
  PS00860 (GTP_CYCLOHYDROL_1_2)
2. PS00859 (GTP_CYCLOH...)
  
  231 - 247
  
  PROSITE patterns
  PS00859 (GTP_CYCLOHYDROL_1_1)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

153 - 216

GENE3D
G3DSA:1.10.286.10 (G3DSA:1.10.286.10)
G3DSA:3.30.11...

222 - 353

GENE3D
G3DSA:3.30.1130.10 (G3DSA:3.30.1130.10)
SSF55620 (Tetrahydr...)

143 - 352

SUPERFAMILY
SSF55620 (Tetrahydrobiopterin biosynthesis enzymes-like)
cd00642 (GTP_cycloh...)

174 - 353

CDD
cd00642 (GTP_cyclohydro1)
mobidb-lite (disord...)

40 - 95

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

homodecamer interf...

174I

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

177A

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

181I

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

184E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

185L

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

187E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

189P

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

191R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

193G

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

194L

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

195R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

197T

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

198P

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

200R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

204A

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

207Y

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

212Y

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

223A

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

225F

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

229H

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

230D

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

231E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

232M

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

234I

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

235V

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

236K

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

237D

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

239D

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

241F

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

245E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

246H

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

249V

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

250P

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

252Y

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

254K

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

261P

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

262N

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

264K

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

268L

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

269S

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

270K

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

273R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

283Q

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

284V

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

285Q

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

287R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

290K

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

300L

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

313H

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

314M

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

315C

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

318M

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

319R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

324P

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

325G

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

327S

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

328T

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

329T

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

331S

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

332C

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

333M

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

338R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

339E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

342K

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

344R

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

345E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)

346E

homodecamer interface
174I, 177A, 181I, 184E, 185L, 187E, 189P, 191R, 193G, 194L, 195R, 197T, 198P, 200R, 204A, 207Y, 212Y, 223A, 225F, 229H, 230D, 231E, 232M, 234I, 235V, 236K, 237D, 239D, 241F, 245E, 246H, 249V, 250P, 252Y, 254K, 261P, 262N, 264K, 268L, 269S, 270K, 273R, 283Q, 284V, 285Q, 287R, 290K, 300L, 313H, 314M, 315C, 318M, 319R, 324P, 325G, 327S, 328T, 329T, 331S, 332C, 333M, 338R, 339E, 342K, 344R, 345E, 346E
CDD
cd00642 (GTP_cyclohydro1)
active site cd00642

200R

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

203R

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

244C

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

246H

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

247H

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

266L

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

268L

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

269S

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

273R

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

284V

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

285Q

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

286E

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

313H

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

315C

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)

319R

active site
200R, 203R, 244C, 246H, 247H, 266L, 268L, 269S, 273R, 284V, 285Q, 286E, 313H, 315C, 319R
CDD
cd00642 (GTP_cyclohydro1)
zinc binding site ...

244C

zinc binding site
244C, 246H, 247H, 315C
CDD
cd00642 (GTP_cyclohydro1)

246H

zinc binding site
244C, 246H, 247H, 315C
CDD
cd00642 (GTP_cyclohydro1)

247H

zinc binding site
244C, 246H, 247H, 315C
CDD
cd00642 (GTP_cyclohydro1)

315C

zinc binding site
244C, 246H, 247H, 315C
CDD
cd00642 (GTP_cyclohydro1)
putative catalytic...

244C

putative catalytic site residues
244C, 246H, 247H, 313H, 315C
CDD
cd00642 (GTP_cyclohydro1)

246H

putative catalytic site residues
244C, 246H, 247H, 313H, 315C
CDD
cd00642 (GTP_cyclohydro1)

247H

putative catalytic site residues
244C, 246H, 247H, 313H, 315C
CDD
cd00642 (GTP_cyclohydro1)

313H

putative catalytic site residues
244C, 246H, 247H, 313H, 315C
CDD
cd00642 (GTP_cyclohydro1)

315C

putative catalytic site residues
244C, 246H, 247H, 313H, 315C
CDD
cd00642 (GTP_cyclohydro1)
GTP-CH-I/GFRP inte...

294M

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

297W

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

303Q

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

305V

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

334L

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

335G

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

336R

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

338R

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

339E

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

340T

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

341H

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

342K

GTP-CH-I/GFRP interaction surface
294M, 297W, 303Q, 305V, 334L, 335G, 336R, 338R, 339E, 340T, 341H, 342K
CDD
cd00642 (GTP_cyclohydro1)

Protein sequence

>MIA_01909_1
MDTHNASLDKDLVHVQQVLAELGFKSSLSELTLSLQPLLQSSDDNRSDSTDHAYTPSATSEDEDQELAEPSSSKVAATPT
STATPNQLPQEISPADLHHPRASSLAANQPSILSSPLANPIVARNLSPLNTKRASSPYTASPPIDYDGLSWPSIGARNRL
EATPSEARARELRIASAVRTILSELGEDPDREGLRETPERYARAMLYFTKGYEDNVRDVINHALFEEDHDEMVIVKDIDV
FSLCEHHLVPFYGKIHIGYIPNSKVLGLSKLARIAEMFARRLQVQERLTKQVAMALWEILQPQGVAVVMEASHMCMVMRG
VQKPGSSTTTSCMLGRFRETHKTREEFLSLLRR

GO term prediction

Biological Process

GO:0046654 tetrahydrofolate biosynthetic process

Molecular Function

GO:0003934 GTP cyclohydrolase I activity

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features