MCA_01479_1

Protein

Length

393 amino acids

Browser: contigA:4582040-4583222-

RNA-seq: read pairs 659, FPKM 20.7, percentile rank 42.3% (100% = highest expression)

Protein function

KEGG:	K01495	GCH1	GTP cyclohydrolase I [EC:3.5.4.16]
EGGNOG:	0PFKM		gtp cyclohydrolase i
SGD closest match:	S000003499	FOL2	GTP cyclohydrolase 1
CGD closest match:	CAL0000195996	orf19.3957	GTP cyclohydrolase I (Fragment)

Protein alignments

	%id	Aln length	E-value
MIA_01909_1	87.08%	240	4e-155	MIA_01909_1
A0A0J9X5V2_GEOCN	90.78%	217	5e-149	Similar to Saccharomyces cerevisiae YGR267C FOL2 GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway OS=Geotrichum candidum GN=BN980_GECA03s03651g PE=3 SV=1
A0A1E3PFG0_9ASCO	88.26%	230	8e-150	GTP cyclohydrolase I OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_28058 PE=3 SV=1
A0A167EAT3_9ASCO	79.76%	247	1e-144	GTP cyclohydrolase I OS=Sugiyamaella lignohabitans GN=FOL2 PE=3 SV=1
Q6CHC2_YARLI	83.33%	228	8e-143	YALI0A10310p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A10310g PE=3 SV=2
UniRef50_Q6CHC2	83.33%	228	2e-139	YALI0A10310p n=31 Tax=Opisthokonta TaxID=33154 RepID=Q6CHC2_YARLI
A0A060T8J3_BLAAD	76.74%	215	5e-123	ARAD1D07392p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07392g PE=3 SV=1
A0A1E4TGX1_9ASCO	77.67%	215	1e-123	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_115382 PE=3 SV=1
A0A1D8PP19_CANAL	76.36%	220	6e-123	GTP cyclohydrolase I (Fragment) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3957 PE=3 SV=1
GCH1_YEAST	73.80%	229	1e-118	GTP cyclohydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0514

Protein family membership

GTP cyclohydrolase I (IPR001474)

Domains and repeats

Domain
214 - 390
GTP cyclohydrolase I domain (IPR020602)

1 50 100 150 200 250 300 350 393

Detailed signature matches

IPR001474

GTP cyclohydrolase I
1. MF_00223 (FolE)
  
  209 - 391
  
  HAMAP
  MF_00223 (FolE)
2. TIGR00063
  
  213 - 391
  
  TIGRFAMs
  TIGR00063 (TIGR00063)
IPR020602

GTP cyclohydrolase I domain
1. PF01227 (GTP_cycloh...)
  
  214 - 390
  
  Pfam
  PF01227 (GTP_cyclohydroI)
IPR018234

GTP cyclohydrolase I, conserved site
1. PS00859 (GTP_CYCLOH...)
  
  270 - 286
  
  PROSITE patterns
  PS00859 (GTP_CYCLOHYDROL_1_1)
2. PS00860 (GTP_CYCLOH...)
  
  318 - 328
  
  PROSITE patterns
  PS00860 (GTP_CYCLOHYDROL_1_2)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

192 - 256

GENE3D
G3DSA:1.10.286.10 (G3DSA:1.10.286.10)
G3DSA:3.30.11...

261 - 393

GENE3D
G3DSA:3.30.1130.10 (G3DSA:3.30.1130.10)
SSF55620 (Tetrahydr...)

180 - 391

SUPERFAMILY
SSF55620 (Tetrahydrobiopterin biosynthesis enzymes-like)
cd00642 (GTP_cycloh...)

208 - 392

CDD
cd00642 (GTP_cyclohydro1)
mobidb-lite (disord...)

99 - 156

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 84

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

homodecamer interf...

208A

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

209R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

212R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

213I

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

216A

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

220L

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

223E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

224L

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

226E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

228P

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

230R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

232G

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

233L

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

234L

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

236T

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

237P

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

239R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

243A

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

246F

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

251Y

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

262A

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

264F

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

268H

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

269D

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

270E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

271M

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

273I

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

274V

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

275K

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

276D

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

278D

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

280F

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

284E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

285H

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

288V

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

289P

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

291Y

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

293K

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

300P

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

301N

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

303K

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

307L

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

308S

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

309K

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

312R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

322Q

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

323V

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

324Q

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

326R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

329K

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

339L

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

352H

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

353M

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

354C

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

357M

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

358R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

363P

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

364G

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

366S

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

367T

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

368T

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

370S

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

371C

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

372M

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

377R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

378E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

381K

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

383R

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

384E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)

385E

homodecamer interface
208A, 209R, 212R, 213I, 216A, 220L, 223E, 224L, 226E, 228P, 230R, 232G, 233L, 234L, 236T, 237P, 239R, 243A, 246F, 251Y, 262A, 264F, 268H, 269D, 270E, 271M, 273I, 274V, 275K, 276D, 278D, 280F, 284E, 285H, 288V, 289P, 291Y, 293K, 300P, 301N, 303K, 307L, 308S, 309K, 312R, 322Q, 323V, 324Q, 326R, 329K, 339L, 352H, 353M, 354C, 357M, 358R, 363P, 364G, 366S, 367T, 368T, 370S, 371C, 372M, 377R, 378E, 381K, 383R, 384E, 385E
CDD
cd00642 (GTP_cyclohydro1)
active site cd00642

239R

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

242R

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

283C

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

285H

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

286H

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

305L

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

307L

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

308S

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

312R

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

323V

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

324Q

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

325E

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

352H

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

354C

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)

358R

active site
239R, 242R, 283C, 285H, 286H, 305L, 307L, 308S, 312R, 323V, 324Q, 325E, 352H, 354C, 358R
CDD
cd00642 (GTP_cyclohydro1)
putative catalytic...

283C

putative catalytic site residues
283C, 285H, 286H, 352H, 354C
CDD
cd00642 (GTP_cyclohydro1)

285H

putative catalytic site residues
283C, 285H, 286H, 352H, 354C
CDD
cd00642 (GTP_cyclohydro1)

286H

putative catalytic site residues
283C, 285H, 286H, 352H, 354C
CDD
cd00642 (GTP_cyclohydro1)

352H

putative catalytic site residues
283C, 285H, 286H, 352H, 354C
CDD
cd00642 (GTP_cyclohydro1)

354C

putative catalytic site residues
283C, 285H, 286H, 352H, 354C
CDD
cd00642 (GTP_cyclohydro1)
zinc binding site ...

283C

zinc binding site
283C, 285H, 286H, 354C
CDD
cd00642 (GTP_cyclohydro1)

285H

zinc binding site
283C, 285H, 286H, 354C
CDD
cd00642 (GTP_cyclohydro1)

286H

zinc binding site
283C, 285H, 286H, 354C
CDD
cd00642 (GTP_cyclohydro1)

354C

zinc binding site
283C, 285H, 286H, 354C
CDD
cd00642 (GTP_cyclohydro1)
GTP-CH-I/GFRP inte...

333M

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

336W

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

342Q

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

344V

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

373L

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

374G

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

375R

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

377R

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

378E

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

379T

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

380S

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

381K

GTP-CH-I/GFRP interaction surface
333M, 336W, 342Q, 344V, 373L, 374G, 375R, 377R, 378E, 379T, 380S, 381K
CDD
cd00642 (GTP_cyclohydro1)

Protein sequence

>MCA_01479_1
MSTDNDDLKQVKQALSEMGLDSLSQPNLDYNNAIDSLSSGANDHHQQPYHPQTLLNSSSESSSKHSLDHSPPSSSITTPS
STTSSSNYMSYHHCQCGHHTQASQQASKVPVDSQADAVNSHPHTPLSLAQFSNNNHNNNNNNMYHSPANGSSSSFQTNPA
VIRALSPLNQKRVESPYTANPPIDYDGLSWPSIGARKRLESTEEEKAAREQRIAGAIRTLLTELGEDPDRQGLLETPERY
ARAMLFFTKGYEDNIKDVINRAVFEEDHDEMVIVKDIDVFSLCEHHLVPFYGKIHIGYIPNSKVLGLSKLARIAEMFSRR
LQVQERLTKQVAMALWEILQPQGVAVVMEASHMCMVMRGVQKPGSSTTTSCMLGRFRETSKTREEFLSLLGRR

GO term prediction

Biological Process

GO:0046654 tetrahydrofolate biosynthetic process

Molecular Function

GO:0003934 GTP cyclohydrolase I activity

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features